Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 218709923

GI number: 218709923

Start: 2078797

End: 2081469

Strand: Reverse

Name: gyrA [H]

Synonym: VS_1936

Alternate gene names: 218709923

Gene position: 2081469-2078797 (Counterclockwise)

Preceding gene: 218709925

Following gene: 218709922

Centisome position: 63.09

GC content: 45.12

Gene sequence:

>2673_bases
ATGAGCGATCTAGCGAAAGAGATCACGCCCGTAAATATTGAAGATGAGCTTAGAGGTTCATACCTAGACTACGCGATGTC
CGTCATCGTTGGTCGTGCCCTTCCAGATGTGCGTGATGGCCTAAAACCAGTACACCGCCGCGTTTTGTTCGCGATGAATG
TATTAGGTAATGATTGGAACAAAGCATATAAAAAGTCTGCTCGTGTAGTAGGCGATGTAATCGGTAAATATCACCCACAC
GGTGATAGTGCGGTATACGAGTCAATTGTTCGTATGGCTCAGCCGTTTTCACTACGCTATATGTTAGTCGATGGCCAAGG
TAACTTTGGTTCGGTTGACGGCGATTCAGCTGCGGCAATGCGTTATACCGAAGTTCGTATGTCAAAAATAGCTGGTGAGC
TATTAACGGATCTTGATAAAGATACGGTTGACTTCGTTCCTAACTATGATGGAACCGAGCAAATACCAGCAGTTTTACCA
ACAAAAATACCAAACCTATTGGTTAACGGTGCTTCTGGTATCGCAGTAGGTATGGCTACCAACATCCCGCCACATAACCT
TGGCGAAGTTGTTGATGGCTGTTTAGCATTTATCAATAATGAAGACATCACTATTGATGAGCTAATGGACTACATCCCGG
GTCCAGACTTCCCGACAGCAGCATTAATCAGTGGCCGTAAGGGCATTGTCGATGCATATAAGACTGGCCGAGGCAAAGTC
TACATGCGCTCGAGAGCTGAAATTGAAACGGAAAAGAACGGTAAAGAAACTATTATCGTTACTGAAATTCCGTATCAAGT
GAACAAAGCTCGTCTGATCGAGAAGATTGCAGAACTTGTAAAAGACAAGAAAGTTGAAGGCATCAGTGCACTGCGTGACG
AATCTGATAAAGATGGTATGCGTATTGTTATTGAATGTAAGCGTGATGCTGTCGGTGAAGTTGTACTAAACAACCTTTAC
TCACAAACTCAACTGCAAACAACTTTCGGCATCAACATGGTTGCTCTGAACAACGGCCAACCACAACTTTTCAACATTAA
AGATATGTTGAAGTGTTTTGTTGATCACCGTCGTGAAGTTGTGACACGTCGTACTATCTTCGAATTGAAGAAAGCGCGCG
ACCGTGCACATATCTTGGAAGCTCTATCTTTAGCGCTTGCAAACATTGATGAAATCATTGAACTGATCAAGAACGCACCA
ACACCAGCAGAAGCTAAAGTCGGTCTAGTATCTCGTGGTTGGGATCTTGGTAACGTTGCATCAATGCTTGAACGTGCTGG
TACTGATGCAGCTCGTCCAGATTGGCTTGAAGACCAATACGGTATCCGTGATGGTCAATACTTCCTAACGGAAACTCAAG
CGCAAGCTATTCTAGAACTTCGTCTTCACCGCCTAACTGGCCTTGAGCACGAGAAGATTCTAGACGAATACAAAGCACTT
CTAGAAGAGATCGCTGAGCTAATGCATATCCTTGCAAGCACTGAGCGTTTGATGGAAGTTATCCGTGAAGAACTTGAAGC
GGTACGTGATATCTATGGCGACGAACGTCGTACAGAAATCACAGCAGCGGTTCATGACATCGACATGGAAGAGCTAATCG
CTCAAGAAGACGTGGTAGTAACGCTTTCTAACGCAGGTTACGTTAAGTACCAAATCCTAAGCGACTACGAAGCTCAGCGT
CGTGGTGGTAAAGGTAAGAGTGCAACTAAGATGAAAGATGAGGATTACATTGAGCGTCTGCTTGTTGCTAATACTCACGA
TAACATCTTATGTTTCTCTACTCGTGGTAAAACGTACCGCCTGAAAGTTTACCAACTGCCTCAAGCAAGCCGCACCGCTC
GTGGTAAGCCTATCGTTAACATTCTTCCTCTAGAAGAGGGTGAGCGTATTACGGCTATCCTGCCTGTTTCTGAGTTCTCT
AACGAGAAATTCATCTTCATGGCAACAGGCGACGGTACCGTTAAGAAGACATCACTGGATCAATTCGCAAACGTACGTGC
TAACGGCCTAATCGCAGTTAACCTACGTGACGATGATTCACTGATTGGCGTTGATATTACTGACGGTAATAGCGACATCA
TGCTGTTCTCGAAGTCGGGCAAAGTTGTTCGCTTTAACGAGGACAAAGTACGTCCAATGGGTCGTACTGCCTCTGGTGTT
CGTGGTATGAAGCTTCCAGAAGACGATCAAGTGGTTTCACTGATTGTTCCTTCAAACGAAGGCGATATCCTAACTGTGAC
TCAAAACGGTTACGGTAAGCGTACTGAGCTGGCTGAATACCCAACGAAAGGCCGTGCAACGCAAGGTGTAGTATCTATCA
AAGTCTCTGATCGTAATGGCCCAGTAGTTGGTGCTGTTCAGGTTGAAGAAGGCGATGAAATGATGATGATCACCGACGCA
GGTACACTTGTACGTACTCGCGTAGCGGAAGTAAGCCAAGTTGGTCGTAACACTCAAGGTGTAACACTGATTCGTACTGC
TGAAGACGAGAATGTTGTAGGTCTACAACGTATCGACGAAGTAGAAGAAGCGGAGATTGTTGAAGGCGAAGAAACTGAAG
AAGCAAATGCTGACGCAGTAAACGCTGAAACGGCTGATGTTTCTGAATCAAGTGAAGAGCAAGCATCTGATGCTTCTGAC
TCTGAAAGTGATAGCGAGCAAGACACTGAGTAA

Upstream 100 bases:

>100_bases
GGAGAGGGAAAGTGATGCCTCCGTAGGTAAATTTGTGTTATATTTTTCGGTCTTATACGTATTCAAAAATACGATCTGAC
TATAGAGGGAAAATGGCTCT

Downstream 100 bases:

>100_bases
TCTCGATTACGTTAAGTAATTAAGCTTACCAATGAAAAAACCGAGCCTAAGTGCTCGGTTTTTTATTGCCTGTCATTTCA
CTTCTCTTCTCATGTGGCTT

Product: DNA gyrase, subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 890; Mature: 889

Protein sequence:

>890_residues
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKAYKKSARVVGDVIGKYHPH
GDSAVYESIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMSKIAGELLTDLDKDTVDFVPNYDGTEQIPAVLP
TKIPNLLVNGASGIAVGMATNIPPHNLGEVVDGCLAFINNEDITIDELMDYIPGPDFPTAALISGRKGIVDAYKTGRGKV
YMRSRAEIETEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLY
SQTQLQTTFGINMVALNNGQPQLFNIKDMLKCFVDHRREVVTRRTIFELKKARDRAHILEALSLALANIDEIIELIKNAP
TPAEAKVGLVSRGWDLGNVASMLERAGTDAARPDWLEDQYGIRDGQYFLTETQAQAILELRLHRLTGLEHEKILDEYKAL
LEEIAELMHILASTERLMEVIREELEAVRDIYGDERRTEITAAVHDIDMEELIAQEDVVVTLSNAGYVKYQILSDYEAQR
RGGKGKSATKMKDEDYIERLLVANTHDNILCFSTRGKTYRLKVYQLPQASRTARGKPIVNILPLEEGERITAILPVSEFS
NEKFIFMATGDGTVKKTSLDQFANVRANGLIAVNLRDDDSLIGVDITDGNSDIMLFSKSGKVVRFNEDKVRPMGRTASGV
RGMKLPEDDQVVSLIVPSNEGDILTVTQNGYGKRTELAEYPTKGRATQGVVSIKVSDRNGPVVGAVQVEEGDEMMMITDA
GTLVRTRVAEVSQVGRNTQGVTLIRTAEDENVVGLQRIDEVEEAEIVEGEETEEANADAVNAETADVSESSEEQASDASD
SESDSEQDTE

Sequences:

>Translated_890_residues
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKAYKKSARVVGDVIGKYHPH
GDSAVYESIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMSKIAGELLTDLDKDTVDFVPNYDGTEQIPAVLP
TKIPNLLVNGASGIAVGMATNIPPHNLGEVVDGCLAFINNEDITIDELMDYIPGPDFPTAALISGRKGIVDAYKTGRGKV
YMRSRAEIETEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLY
SQTQLQTTFGINMVALNNGQPQLFNIKDMLKCFVDHRREVVTRRTIFELKKARDRAHILEALSLALANIDEIIELIKNAP
TPAEAKVGLVSRGWDLGNVASMLERAGTDAARPDWLEDQYGIRDGQYFLTETQAQAILELRLHRLTGLEHEKILDEYKAL
LEEIAELMHILASTERLMEVIREELEAVRDIYGDERRTEITAAVHDIDMEELIAQEDVVVTLSNAGYVKYQILSDYEAQR
RGGKGKSATKMKDEDYIERLLVANTHDNILCFSTRGKTYRLKVYQLPQASRTARGKPIVNILPLEEGERITAILPVSEFS
NEKFIFMATGDGTVKKTSLDQFANVRANGLIAVNLRDDDSLIGVDITDGNSDIMLFSKSGKVVRFNEDKVRPMGRTASGV
RGMKLPEDDQVVSLIVPSNEGDILTVTQNGYGKRTELAEYPTKGRATQGVVSIKVSDRNGPVVGAVQVEEGDEMMMITDA
GTLVRTRVAEVSQVGRNTQGVTLIRTAEDENVVGLQRIDEVEEAEIVEGEETEEANADAVNAETADVSESSEEQASDASD
SESDSEQDTE
>Mature_889_residues
SDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKAYKKSARVVGDVIGKYHPHG
DSAVYESIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMSKIAGELLTDLDKDTVDFVPNYDGTEQIPAVLPT
KIPNLLVNGASGIAVGMATNIPPHNLGEVVDGCLAFINNEDITIDELMDYIPGPDFPTAALISGRKGIVDAYKTGRGKVY
MRSRAEIETEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLYS
QTQLQTTFGINMVALNNGQPQLFNIKDMLKCFVDHRREVVTRRTIFELKKARDRAHILEALSLALANIDEIIELIKNAPT
PAEAKVGLVSRGWDLGNVASMLERAGTDAARPDWLEDQYGIRDGQYFLTETQAQAILELRLHRLTGLEHEKILDEYKALL
EEIAELMHILASTERLMEVIREELEAVRDIYGDERRTEITAAVHDIDMEELIAQEDVVVTLSNAGYVKYQILSDYEAQRR
GGKGKSATKMKDEDYIERLLVANTHDNILCFSTRGKTYRLKVYQLPQASRTARGKPIVNILPLEEGERITAILPVSEFSN
EKFIFMATGDGTVKKTSLDQFANVRANGLIAVNLRDDDSLIGVDITDGNSDIMLFSKSGKVVRFNEDKVRPMGRTASGVR
GMKLPEDDQVVSLIVPSNEGDILTVTQNGYGKRTELAEYPTKGRATQGVVSIKVSDRNGPVVGAVQVEEGDEMMMITDAG
TLVRTRVAEVSQVGRNTQGVTLIRTAEDENVVGLQRIDEVEEAEIVEGEETEEANADAVNAETADVSESSEEQASDASDS
ESDSEQDTE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=419, Percent_Identity=25.5369928400955, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=875, Percent_Identity=74.0571428571428, Blast_Score=1341, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=718, Percent_Identity=36.908077994429, Blast_Score=425, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17535065, Length=283, Percent_Identity=28.9752650176678, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=282, Percent_Identity=28.7234042553192, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=404, Percent_Identity=25, Blast_Score=76, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=346, Percent_Identity=26.0115606936416, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136538, Length=354, Percent_Identity=28.8135593220339, Blast_Score=80, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98372; Mature: 98240

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KAYKKSARVVGDVIGKYHPHGDSAVYESIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMSKIAGELLTDLDKDTVDFVPNYDGTEQIPAVLPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLGEVVDGCLAFINNEDITIDELMDYIPGPDFPTAALISGRKGIVDAYKTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHCCCCEE
YMRSRAEIETEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGM
EEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
RIVIECKRDAVGEVVLNNLYSQTQLQTTFGINMVALNNGQPQLFNIKDMLKCFVDHRREV
EEEEEECCCHHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELKKARDRAHILEALSLALANIDEIIELIKNAPTPAEAKVGLVSRGWDLGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHEEEEEECCCCHHHHH
SMLERAGTDAARPDWLEDQYGIRDGQYFLTETQAQAILELRLHRLTGLEHEKILDEYKAL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LEEIAELMHILASTERLMEVIREELEAVRDIYGDERRTEITAAVHDIDMEELIAQEDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCEEE
TLSNAGYVKYQILSDYEAQRRGGKGKSATKMKDEDYIERLLVANTHDNILCFSTRGKTYR
EEECCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEE
LKVYQLPQASRTARGKPIVNILPLEEGERITAILPVSEFSNEKFIFMATGDGTVKKTSLD
EEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCEEEEEEECCCCEEECCHH
QFANVRANGLIAVNLRDDDSLIGVDITDGNSDIMLFSKSGKVVRFNEDKVRPMGRTASGV
HHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCC
RGMKLPEDDQVVSLIVPSNEGDILTVTQNGYGKRTELAEYPTKGRATQGVVSIKVSDRNG
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCC
PVVGAVQVEEGDEMMMITDAGTLVRTRVAEVSQVGRNTQGVTLIRTAEDENVVGLQRIDE
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCC
VEEAEIVEGEETEEANADAVNAETADVSESSEEQASDASDSESDSEQDTE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KAYKKSARVVGDVIGKYHPHGDSAVYESIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMSKIAGELLTDLDKDTVDFVPNYDGTEQIPAVLPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLGEVVDGCLAFINNEDITIDELMDYIPGPDFPTAALISGRKGIVDAYKTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHCCCCEE
YMRSRAEIETEKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGM
EEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCC
RIVIECKRDAVGEVVLNNLYSQTQLQTTFGINMVALNNGQPQLFNIKDMLKCFVDHRREV
EEEEEECCCHHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELKKARDRAHILEALSLALANIDEIIELIKNAPTPAEAKVGLVSRGWDLGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHEEEEEECCCCHHHHH
SMLERAGTDAARPDWLEDQYGIRDGQYFLTETQAQAILELRLHRLTGLEHEKILDEYKAL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LEEIAELMHILASTERLMEVIREELEAVRDIYGDERRTEITAAVHDIDMEELIAQEDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCEEE
TLSNAGYVKYQILSDYEAQRRGGKGKSATKMKDEDYIERLLVANTHDNILCFSTRGKTYR
EEECCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEE
LKVYQLPQASRTARGKPIVNILPLEEGERITAILPVSEFSNEKFIFMATGDGTVKKTSLD
EEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCEEEEEEECCCCEEECCHH
QFANVRANGLIAVNLRDDDSLIGVDITDGNSDIMLFSKSGKVVRFNEDKVRPMGRTASGV
HHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCC
RGMKLPEDDQVVSLIVPSNEGDILTVTQNGYGKRTELAEYPTKGRATQGVVSIKVSDRNG
CCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCC
PVVGAVQVEEGDEMMMITDAGTLVRTRVAEVSQVGRNTQGVTLIRTAEDENVVGLQRIDE
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCC
VEEAEIVEGEETEEANADAVNAETADVSESSEEQASDASDSESDSEQDTE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]