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The map label for this gene is yisQ [H]

Identifier: 218709836

GI number: 218709836

Start: 1997417

End: 1998790

Strand: Reverse

Name: yisQ [H]

Synonym: VS_1849

Alternate gene names: 218709836

Gene position: 1998790-1997417 (Counterclockwise)

Preceding gene: 218709838

Following gene: 218709835

Centisome position: 60.58

GC content: 46.14

Gene sequence:

>1374_bases
ATGTTGCTCTCTTCAATTATTCATCACACTCGAGGTGATTTTGTTCGTAGGCTTATTGCGATTGCTTTGCCTATTACTTT
GCAGAGCATTATGTTTTCAAGCCGAGGCTTAGTCGATGTGTTGATGTTAGGCCAATTGGGTGAAGCGGATATTGCGGCGG
TGGGTGTGGCGAGTCGAGCCATGTTTGTCACGACCATTATGCTGGTGGGTGTCACCACGGGTGGTGCGTTATTGACTGCG
CAATATTGGGGAGCAGGTAACAAGCAAGGCGTCAGAGAAAGTACGGCGTTGACTTGGCTGGTTTCAACACTGTTTGCATT
ACTAACTATTGTTTTCTTCGTTTCATTTCCCGCACAAATCATGGGCGTGACGACTGACTCCCAAGAAGTGATCAACCTTG
GTGTTGAATACATTGTTATCACCTCGTTTAGCATGCTAGCTGTATCGTGCGTTAGCAGTATGGCTGTAGGTTTGAGATCG
ATGCACAAACCCGGGCTAAGCACCTTCTTCAGCGGTATCGGTATCCTGTCTAACGTGTTCTTAAACTGGGTGCTGATCTT
CGGTAACTTAGGCTTTCCTGCGCTTGGAATCAAAGGTGCGGCGATTGCGACGGTATTGAGCGGTGCCATTGAAGTGGCGA
CCTTATATGGTTATCTTTATTGTTCAAAGCATCTCTTGGCTTTCAAGTTATGCGATATAAAAGCAGCAGCTTCGATTGAA
AAAGTGGTTCGCTTCTTAAAGTTATCGCTGCCGACGACGTTTAACTTTTTGGCGTGGGCGGGTGGCTTATTTGCTTACCA
CGCGATCATGGGGCAATCGGGCGTTCAAGGACTGGCAGCACTGTCAGTGATGACGCCGGTTGAATCTATCTCATTGAGTT
TACTGATTGGCCTTTCGAATGCGGCAGCGGTTCTGGTGGGTAATCAACTTGGCGCAAAGAATAATGAAGCGGTTTATTAC
CAAGCGTTAGGCTTAACGATTTTGTGTTTCTTGACCAGTATCGTGGTCGCGATTTTTCTTTACTTCGTACAAACGCCAAT
ACTGAATGCTTTTAGTGCACTGACGGAAGAAACCAGAGCCCTCTCAGAAAAGTTCATTCTAATTTTAAGCGTGGGTATTG
TTATCCGATCGGTACCGCTGACTGTCATTGTTGGTGTGTTGAGAGCGGGCGGTGATGTGAAGTTCTGCCTTTATCAAGAC
CTGATTGCCCAATGGGTGATCGGTATTCCGCTCGCCGCGATTGCTGCTATCTATCTGAAGTTTCCACCTGAGTGGATATA
TCTACTTTTCCTCACTGAAGAAGTACTTAAGTGGGGTGGGTCGCTCTATCGCATGAAAACAAGAAAATGGATTAAAAACT
TGATAGGAAATTGA

Upstream 100 bases:

>100_bases
TCATTGTTACTCCATTTATCTCTGTGGTTAAAAACCGAACATTGATATAATAGCGCGATATTTATCTTTATTCATCAATA
CGTTCCGTTTAGGTATCTCT

Downstream 100 bases:

>100_bases
AGTAGAGCGCATCAACCCCATCACTTTATCGTTGGTGTGTGATCTATCTTTCAAAATACTTCCTCCTAACAGGGAATTAG
TGTAGATTCTCATTCCAAAT

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLLSSIIHHTRGDFVRRLIAIALPITLQSIMFSSRGLVDVLMLGQLGEADIAAVGVASRAMFVTTIMLVGVTTGGALLTA
QYWGAGNKQGVRESTALTWLVSTLFALLTIVFFVSFPAQIMGVTTDSQEVINLGVEYIVITSFSMLAVSCVSSMAVGLRS
MHKPGLSTFFSGIGILSNVFLNWVLIFGNLGFPALGIKGAAIATVLSGAIEVATLYGYLYCSKHLLAFKLCDIKAAASIE
KVVRFLKLSLPTTFNFLAWAGGLFAYHAIMGQSGVQGLAALSVMTPVESISLSLLIGLSNAAAVLVGNQLGAKNNEAVYY
QALGLTILCFLTSIVVAIFLYFVQTPILNAFSALTEETRALSEKFILILSVGIVIRSVPLTVIVGVLRAGGDVKFCLYQD
LIAQWVIGIPLAAIAAIYLKFPPEWIYLLFLTEEVLKWGGSLYRMKTRKWIKNLIGN

Sequences:

>Translated_457_residues
MLLSSIIHHTRGDFVRRLIAIALPITLQSIMFSSRGLVDVLMLGQLGEADIAAVGVASRAMFVTTIMLVGVTTGGALLTA
QYWGAGNKQGVRESTALTWLVSTLFALLTIVFFVSFPAQIMGVTTDSQEVINLGVEYIVITSFSMLAVSCVSSMAVGLRS
MHKPGLSTFFSGIGILSNVFLNWVLIFGNLGFPALGIKGAAIATVLSGAIEVATLYGYLYCSKHLLAFKLCDIKAAASIE
KVVRFLKLSLPTTFNFLAWAGGLFAYHAIMGQSGVQGLAALSVMTPVESISLSLLIGLSNAAAVLVGNQLGAKNNEAVYY
QALGLTILCFLTSIVVAIFLYFVQTPILNAFSALTEETRALSEKFILILSVGIVIRSVPLTVIVGVLRAGGDVKFCLYQD
LIAQWVIGIPLAAIAAIYLKFPPEWIYLLFLTEEVLKWGGSLYRMKTRKWIKNLIGN
>Mature_457_residues
MLLSSIIHHTRGDFVRRLIAIALPITLQSIMFSSRGLVDVLMLGQLGEADIAAVGVASRAMFVTTIMLVGVTTGGALLTA
QYWGAGNKQGVRESTALTWLVSTLFALLTIVFFVSFPAQIMGVTTDSQEVINLGVEYIVITSFSMLAVSCVSSMAVGLRS
MHKPGLSTFFSGIGILSNVFLNWVLIFGNLGFPALGIKGAAIATVLSGAIEVATLYGYLYCSKHLLAFKLCDIKAAASIE
KVVRFLKLSLPTTFNFLAWAGGLFAYHAIMGQSGVQGLAALSVMTPVESISLSLLIGLSNAAAVLVGNQLGAKNNEAVYY
QALGLTILCFLTSIVVAIFLYFVQTPILNAFSALTEETRALSEKFILILSVGIVIRSVPLTVIVGVLRAGGDVKFCLYQD
LIAQWVIGIPLAAIAAIYLKFPPEWIYLLFLTEEVLKWGGSLYRMKTRKWIKNLIGN

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49129; Mature: 49129

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSSIIHHTRGDFVRRLIAIALPITLQSIMFSSRGLVDVLMLGQLGEADIAAVGVASRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
MFVTTIMLVGVTTGGALLTAQYWGAGNKQGVRESTALTWLVSTLFALLTIVFFVSFPAQI
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MGVTTDSQEVINLGVEYIVITSFSMLAVSCVSSMAVGLRSMHKPGLSTFFSGIGILSNVF
EECCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LNWVLIFGNLGFPALGIKGAAIATVLSGAIEVATLYGYLYCSKHLLAFKLCDIKAAASIE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVVRFLKLSLPTTFNFLAWAGGLFAYHAIMGQSGVQGLAALSVMTPVESISLSLLIGLSN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCC
AAAVLVGNQLGAKNNEAVYYQALGLTILCFLTSIVVAIFLYFVQTPILNAFSALTEETRA
CEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEKFILILSVGIVIRSVPLTVIVGVLRAGGDVKFCLYQDLIAQWVIGIPLAAIAAIYLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHC
FPPEWIYLLFLTEEVLKWGGSLYRMKTRKWIKNLIGN
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSSIIHHTRGDFVRRLIAIALPITLQSIMFSSRGLVDVLMLGQLGEADIAAVGVASRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHH
MFVTTIMLVGVTTGGALLTAQYWGAGNKQGVRESTALTWLVSTLFALLTIVFFVSFPAQI
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MGVTTDSQEVINLGVEYIVITSFSMLAVSCVSSMAVGLRSMHKPGLSTFFSGIGILSNVF
EECCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LNWVLIFGNLGFPALGIKGAAIATVLSGAIEVATLYGYLYCSKHLLAFKLCDIKAAASIE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVVRFLKLSLPTTFNFLAWAGGLFAYHAIMGQSGVQGLAALSVMTPVESISLSLLIGLSN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCC
AAAVLVGNQLGAKNNEAVYYQALGLTILCFLTSIVVAIFLYFVQTPILNAFSALTEETRA
CEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEKFILILSVGIVIRSVPLTVIVGVLRAGGDVKFCLYQDLIAQWVIGIPLAAIAAIYLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHC
FPPEWIYLLFLTEEVLKWGGSLYRMKTRKWIKNLIGN
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]