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The map label for this gene is cqsS [H]

Identifier: 218709714

GI number: 218709714

Start: 1852220

End: 1854268

Strand: Reverse

Name: cqsS [H]

Synonym: VS_1725

Alternate gene names: 218709714

Gene position: 1854268-1852220 (Counterclockwise)

Preceding gene: 218709715

Following gene: 218709711

Centisome position: 56.2

GC content: 42.41

Gene sequence:

>2049_bases
ATGAACGCGATTCGTAAAGTTTATCAGTACGCAGAACCTAACCTAACCCTTGTGGGTTGGATGGGCTTTGTCGGTTTCCC
TGCTTACTACATTGTATGGGAATTCTTGTTTCCGCAACCCTATGAAAATTTAGCCGTGCGTCTGTTTTGCTCGGTATTGT
TCCTTGGGATTGTTGTTCGTAATCGTATTCCATTTGATTGGCGAAAGTACCTTCCGGCTTATTATCAAGTCGCTATTACC
CTCTGCTTACCGTGTTTTTTCTTTTACATGCTGCTGATGAATAACTGGTCCAACGTATGGGTTATGTCTTTCATGTCGGC
TATTTTCCTCCATATTCTATTAGTTCACGTCACCCGAGTGATGTTTGCACAAACCTTCGCCGGGATAGGGATTGCTACCT
TGTGTGCATGGGTGGCACAAGGCTTCTACTTAGAGCTCACTATGGATTGGACGCATGTGCCAATCTTCTTATTTATCTAT
TTGTTCGGTAACTTATTTTACTTCCGTAATCAGGTGGAACATGAGAATAAGGTGTCATTGGCGAAATCTTTTGGAGCTGG
TATCGCGCATGAGATGCGAAACCCACTAAGTGGTTTACTGACATCTATTGATGTTATGCAGTCCATATTGCCGAATCCGA
AAAGTGGTGGCCACCAAGGGCAATACGCTTTGAGTAATGAAGAAGTTATACAGTTACGTGAAGTGGGTGATGAAGCGATG
GAGATTATTCACTCAGGTAACGAGACGATTGATCTGCTATTGACTTCAATTGATGAAAACCGAGTATCTCGTTCTACGTT
CAAGAAACATTCAGCTCAAGCGGTGGTGGAAGGGGCGATAGATAGCTTTAACTATAAGCGCTCAGCTGATAAATCAGCGA
TCTCTTTAGATGTACAAAGCAACTTTGACTTCTTGGGTAGTGATACCTTGTTGAAGTACGTGATGTATAACTTGTTCAAG
AACGCATTCCATCATCGCAGCCCTGAAGATTTTCATATTCATGTCACCATGTGCAGTGATGACGTGACCAATCAAATTAT
GGTTACCGATAACGGATCTGGTATTTCAAACGATGTCATTCGACGTATCTTCCAGGATTTTTACACCACCGGCCAATCAG
GTAACTACGGCTTAGGTTTGCCATTTTGTCAGAAGGTAATGCGGTCGTTTGGTGGAGAGATTAAGTGTAAGTCTGAGGTG
GAACAGTGGACGCAGTTCACGATGACTTTTCCATCTTTGACTTCTCACTCTGTGAACGAAATTAAGAGTGAGCTCACTAA
GCTAAAGACAGTGTTGATGGTGAGTGACCAGAAAGTACTCTCTGATAAAATTACTGAGACATCACGTTTTATGGGGTTTG
ACCTCACCGTATTAGACGTTGTATCAGCACTTAAAAATAAGGAATATCAATTTGAGTTCGACTTGATTTTCGTTGATATG
GAGAGCTTAGATTTAAGAGCCAATTACCTCGATAGAATTGAATCTTTACTATCGTTCACTGAAGCGAGAATCATCTATTT
GTATGAGCATCACCCCATTAAGCGTGTTCGTAACGTTGCTTTTGAACCGATTTGGGTGGAAACACAAGTTTGGCTACTGA
ATACCAAAGCCACCATCGAGCGCTTACTTTTCGATTCCAATTACGTGTTGCCGTCGGTTGCTGTGAAACCACTAGAGGCG
ACTAATAAACGTACGATAATGGTGGTGGATGACAACGAATCTTTGCGCCGTTTTACCGCAATGTTATTGGAAAAACAGGG
CTTTGACGTTGTACAGAAAGAAGATGGCCAACAAGCGTTAGATGCTTTGGATACCGAGGATGTTGATTTGATTCTGATGG
ATATCGAGATGCCAATTATGGATGGTATTGAAGCTTCTCGTCGAATCCGCAGTGCAGCCAAAGAATACTCTACAGTGCCG
ATTATTGCTCACACAGGCGACAGTTCCCCAGTGACATTGGAAAAAATGGAATCGTCAGGCATGTCAGATTTTATTGTGAA
GCCAGCAGATAAAACCCGACTGTTCGATAAAATTGCACACTGGATTTGA

Upstream 100 bases:

>100_bases
TGCTCTGAGGTGATGTGTAATATACTCAGCGGAAAACATAAGAACCAACATCAAATTTTAGACTTTGTAAACGTTAGGGC
TTAGTAAATAAAGTATTTGT

Downstream 100 bases:

>100_bases
TTGGTTGTACCGTCCGGTTATCCAGCTGAACTAGATGAATAGATGAACACAAGAAAGAGCTCAGCAATTCGCTGGGCTCT
TTTTGTATCGCGACATGATA

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MNAIRKVYQYAEPNLTLVGWMGFVGFPAYYIVWEFLFPQPYENLAVRLFCSVLFLGIVVRNRIPFDWRKYLPAYYQVAIT
LCLPCFFFYMLLMNNWSNVWVMSFMSAIFLHILLVHVTRVMFAQTFAGIGIATLCAWVAQGFYLELTMDWTHVPIFLFIY
LFGNLFYFRNQVEHENKVSLAKSFGAGIAHEMRNPLSGLLTSIDVMQSILPNPKSGGHQGQYALSNEEVIQLREVGDEAM
EIIHSGNETIDLLLTSIDENRVSRSTFKKHSAQAVVEGAIDSFNYKRSADKSAISLDVQSNFDFLGSDTLLKYVMYNLFK
NAFHHRSPEDFHIHVTMCSDDVTNQIMVTDNGSGISNDVIRRIFQDFYTTGQSGNYGLGLPFCQKVMRSFGGEIKCKSEV
EQWTQFTMTFPSLTSHSVNEIKSELTKLKTVLMVSDQKVLSDKITETSRFMGFDLTVLDVVSALKNKEYQFEFDLIFVDM
ESLDLRANYLDRIESLLSFTEARIIYLYEHHPIKRVRNVAFEPIWVETQVWLLNTKATIERLLFDSNYVLPSVAVKPLEA
TNKRTIMVVDDNESLRRFTAMLLEKQGFDVVQKEDGQQALDALDTEDVDLILMDIEMPIMDGIEASRRIRSAAKEYSTVP
IIAHTGDSSPVTLEKMESSGMSDFIVKPADKTRLFDKIAHWI

Sequences:

>Translated_682_residues
MNAIRKVYQYAEPNLTLVGWMGFVGFPAYYIVWEFLFPQPYENLAVRLFCSVLFLGIVVRNRIPFDWRKYLPAYYQVAIT
LCLPCFFFYMLLMNNWSNVWVMSFMSAIFLHILLVHVTRVMFAQTFAGIGIATLCAWVAQGFYLELTMDWTHVPIFLFIY
LFGNLFYFRNQVEHENKVSLAKSFGAGIAHEMRNPLSGLLTSIDVMQSILPNPKSGGHQGQYALSNEEVIQLREVGDEAM
EIIHSGNETIDLLLTSIDENRVSRSTFKKHSAQAVVEGAIDSFNYKRSADKSAISLDVQSNFDFLGSDTLLKYVMYNLFK
NAFHHRSPEDFHIHVTMCSDDVTNQIMVTDNGSGISNDVIRRIFQDFYTTGQSGNYGLGLPFCQKVMRSFGGEIKCKSEV
EQWTQFTMTFPSLTSHSVNEIKSELTKLKTVLMVSDQKVLSDKITETSRFMGFDLTVLDVVSALKNKEYQFEFDLIFVDM
ESLDLRANYLDRIESLLSFTEARIIYLYEHHPIKRVRNVAFEPIWVETQVWLLNTKATIERLLFDSNYVLPSVAVKPLEA
TNKRTIMVVDDNESLRRFTAMLLEKQGFDVVQKEDGQQALDALDTEDVDLILMDIEMPIMDGIEASRRIRSAAKEYSTVP
IIAHTGDSSPVTLEKMESSGMSDFIVKPADKTRLFDKIAHWI
>Mature_682_residues
MNAIRKVYQYAEPNLTLVGWMGFVGFPAYYIVWEFLFPQPYENLAVRLFCSVLFLGIVVRNRIPFDWRKYLPAYYQVAIT
LCLPCFFFYMLLMNNWSNVWVMSFMSAIFLHILLVHVTRVMFAQTFAGIGIATLCAWVAQGFYLELTMDWTHVPIFLFIY
LFGNLFYFRNQVEHENKVSLAKSFGAGIAHEMRNPLSGLLTSIDVMQSILPNPKSGGHQGQYALSNEEVIQLREVGDEAM
EIIHSGNETIDLLLTSIDENRVSRSTFKKHSAQAVVEGAIDSFNYKRSADKSAISLDVQSNFDFLGSDTLLKYVMYNLFK
NAFHHRSPEDFHIHVTMCSDDVTNQIMVTDNGSGISNDVIRRIFQDFYTTGQSGNYGLGLPFCQKVMRSFGGEIKCKSEV
EQWTQFTMTFPSLTSHSVNEIKSELTKLKTVLMVSDQKVLSDKITETSRFMGFDLTVLDVVSALKNKEYQFEFDLIFVDM
ESLDLRANYLDRIESLLSFTEARIIYLYEHHPIKRVRNVAFEPIWVETQVWLLNTKATIERLLFDSNYVLPSVAVKPLEA
TNKRTIMVVDDNESLRRFTAMLLEKQGFDVVQKEDGQQALDALDTEDVDLILMDIEMPIMDGIEASRRIRSAAKEYSTVP
IIAHTGDSSPVTLEKMESSGMSDFIVKPADKTRLFDKIAHWI

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=254, Percent_Identity=27.5590551181102, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=117, Percent_Identity=36.7521367521368, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=33.0434782608696, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=25.3164556962025, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78126; Mature: 78126

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure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CCCEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA