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The map label for this gene is tpm

Identifier: 218709707

GI number: 218709707

Start: 1845418

End: 1846071

Strand: Reverse

Name: tpm

Synonym: VS_1718

Alternate gene names: 218709707

Gene position: 1846071-1845418 (Counterclockwise)

Preceding gene: 218709710

Following gene: 218709699

Centisome position: 55.95

GC content: 43.73

Gene sequence:

>654_bases
ATGAATAATCCTGAATTTTGGCACAATAAATGGGCAGCCAACCAAATTGGTTTCCACCTCGAAGATGTAAACCCACTTCT
GATTAAATTTTGGGAAAAGACTGAGCCTAACTACGAGAAGAGTGTGTTTGTTCCACTTTGTGGCAAGAGTGAAGATTTGA
TTTGGTTAGCGACCAAGCATGAAGAGGTTCAAGGTGTCGAGTTAAGCCAGATTGCAGTTCGCGCATTTTTTGCAGAGCAC
CTTTACACACCGACAGTGACTCAAATTAGCGGTCAGCACGAGCTGTATCAATTCGATGAACTGAACATCTACACGGGTGA
TTACTTCACAGCACCAATCCAGCCTGTCGATACCATTTATGATCGCGCGTCTTTAGTCGCATTGCCTGCTGAGATTCGCG
CGCAATATGTGGAACGTTTAAAGCAACTGTTAAAGCCAGGCGGCAAGATTTTATTGGTGACATTGGACTACGATCAAAGC
GAGATGGCAGGGCCTCCGTTTAGCGTACCTAAGCTAGAGATCGATCAGTTGTTTGCTGGTTATAAGATTACTTTGTTGAA
TCAAGATATCGCAGACGATGAACACCCTAAGATTGCGAAGAAAGGCTTGTCGCGATTCAGTGAAGAAGTGTATTTGATTG
AGTCAGAAGCTTAA

Upstream 100 bases:

>100_bases
GATTTCATCGAAACCAATTTGGTACTTTAAACCAAGCTAAGGTTGCTCTTACCTCTCTATACTGTACCCTTGCATTATGA
CTGTTTAACATGAACGAAAG

Downstream 100 bases:

>100_bases
GCGCTTTGAACTCTCAAGCAAACAGATGATTTCGATACAAAAGATAACACCAACAAAAAGACGGGCTCGATAGCCCGTCT
TTTTTATTATTCAGATTTGA

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNNPEFWHNKWAANQIGFHLEDVNPLLIKFWEKTEPNYEKSVFVPLCGKSEDLIWLATKHEEVQGVELSQIAVRAFFAEH
LYTPTVTQISGQHELYQFDELNIYTGDYFTAPIQPVDTIYDRASLVALPAEIRAQYVERLKQLLKPGGKILLVTLDYDQS
EMAGPPFSVPKLEIDQLFAGYKITLLNQDIADDEHPKIAKKGLSRFSEEVYLIESEA

Sequences:

>Translated_217_residues
MNNPEFWHNKWAANQIGFHLEDVNPLLIKFWEKTEPNYEKSVFVPLCGKSEDLIWLATKHEEVQGVELSQIAVRAFFAEH
LYTPTVTQISGQHELYQFDELNIYTGDYFTAPIQPVDTIYDRASLVALPAEIRAQYVERLKQLLKPGGKILLVTLDYDQS
EMAGPPFSVPKLEIDQLFAGYKITLLNQDIADDEHPKIAKKGLSRFSEEVYLIESEA
>Mature_217_residues
MNNPEFWHNKWAANQIGFHLEDVNPLLIKFWEKTEPNYEKSVFVPLCGKSEDLIWLATKHEEVQGVELSQIAVRAFFAEH
LYTPTVTQISGQHELYQFDELNIYTGDYFTAPIQPVDTIYDRASLVALPAEIRAQYVERLKQLLKPGGKILLVTLDYDQS
EMAGPPFSVPKLEIDQLFAGYKITLLNQDIADDEHPKIAKKGLSRFSEEVYLIESEA

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=219, Percent_Identity=32.4200913242009, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_VIBSL (B7VPF3)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002417328.1
- GeneID:   7161286
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_1718
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24874; Mature: 24874

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: BINDING 11-11 BINDING 46-46 BINDING 67-67 BINDING 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPEFWHNKWAANQIGFHLEDVNPLLIKFWEKTEPNYEKSVFVPLCGKSEDLIWLATKH
CCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECC
EEVQGVELSQIAVRAFFAEHLYTPTVTQISGQHELYQFDELNIYTGDYFTAPIQPVDTIY
CCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCEEEEECCEEECCCCHHHHHH
DRASLVALPAEIRAQYVERLKQLLKPGGKILLVTLDYDQSEMAGPPFSVPKLEIDQLFAG
CCHHEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCCCCCCCCEEHHHHHCC
YKITLLNQDIADDEHPKIAKKGLSRFSEEVYLIESEA
EEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCC
>Mature Secondary Structure
MNNPEFWHNKWAANQIGFHLEDVNPLLIKFWEKTEPNYEKSVFVPLCGKSEDLIWLATKH
CCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECC
EEVQGVELSQIAVRAFFAEHLYTPTVTQISGQHELYQFDELNIYTGDYFTAPIQPVDTIY
CCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCEEEEECCEEECCCCHHHHHH
DRASLVALPAEIRAQYVERLKQLLKPGGKILLVTLDYDQSEMAGPPFSVPKLEIDQLFAG
CCHHEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCCCCCCCCEEHHHHHCC
YKITLLNQDIADDEHPKIAKKGLSRFSEEVYLIESEA
EEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA