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The map label for this gene is moeA [H]

Identifier: 218709494

GI number: 218709494

Start: 1637370

End: 1639187

Strand: Direct

Name: moeA [H]

Synonym: VS_1503

Alternate gene names: 218709494

Gene position: 1637370-1639187 (Clockwise)

Preceding gene: 218709493

Following gene: 218709497

Centisome position: 49.63

GC content: 46.81

Gene sequence:

>1818_bases
ATGAAAGATTCGAAACAACGCCCTAACCTTCCTTTATTGGGCTTTGCTGCTTACAGTGGCACAGGCAAAACAACCGTACT
TGAAGCGTTGCTGCCTCTGCTGACTAATGCGGGTTTAAAAGTAGGTGTTCTTAAGCACGCCCACCACGATTTCGATGTCG
ATAAGCCGGGTAAAGACAGCTACCGTTTACGCAAAGCGGGCGCAAATCAAATGCTGATAGCTTCTCGAAACCGTCACGTG
ATGATGACTGAGACTCCAGAAGCGGAAGCCGATTTTGATTACCTGTTGACTCGCTTTGATACCAACACACTTGATCTAAT
TTTGGTTGAAGGCTGTAAGAACATTGCTTTCCCTAAAATCGAGCTTCACCGTGATGAAGTGGGTAAACCTTGGTTGTACC
AAAACGATGACAACATCATTGCTATTGCTGCTGATAGCCAAGTTGAATCTGACTTGCCTCAAATGGCGATCAACGACTTA
GAAGCGATTCGTGATTTCATCATTGATTACGCGCAGTCCTTTGACCTTTCCTCTACAAAAGGCAAAGCAGCGTCATGCTC
ATCTTCAAAAGACGCAGCGCCCGCGGTGTGTTGTGATTCGTTCTCTCCAGCAGGTTTAACCGTAACTCAGGGCCAACAAA
AGATTGTTGATAGCATTGACGCGCTTGATCTCACAGAGAATGTTGAATTACTGCAAGGCTACGGTCGTGTGTTGGCTGAA
GATGTGATCTCGCCAATCAACGTCCCACAGAATACTAATTCTGCAATGGATGGCTACGCGATTCGTAGTGAAGATCTTGA
ATTGGATAGCTACAACATTGTTGCTGAAGTTATGGCTGGTCACAGCTACGACAAAACCGTTCAACAAGGTGAAGCTGTTA
AGATCATGACGGGTGCACCAATGCCAGATGGCGTTGATGTTGTTGTGATGCGTGAGCAAGCCGTGCAAGATGGCGATAAA
GTTAGCTTCCCAGATGCGAAAATCTCAGTTGGACAAAATGTCCGTATGGCCGGTGAAGATTTAGAAATTGGCCAACCTGT
CTTTACACGTGGCACACGCATCGAAGCACCAGAAATGGGTATGATGGCGTCGTTAGGTTTCGGTACCTGCCCTGTTCTGC
GTAAAGTGAAGGTGGGTGTGTTCTCAACGGGTGATGAAGTTCAGGCACCGGGCGTTGAGCAAAAGCCAAACTCTATCTAC
GACTCGAACCGTTTCACTATCATCGGCATGCTTCAAAAGCTAGGTTGCGACATCGTTGATTACGGCATTATCGAAGATGA
CGAACAAAAGATGATGGATGTACTTCATGCTGCGTCGCTTGAAACCGATATGGTTCTGACTTCTGGTGGCGTGTCTGTTG
GTGATGCTGACTACATCAAACTCGCGTTAGATAAGTTGGGTGAGATTAACTTCTGGCGTATCAACATGCGTCCAGGTCGC
CCTCTTGCTTACGGCAAAATTGAAGACAAACCTTTCTTCGGTTTACCTGGCAACCCAGTAGCCGTGATGGTGTCGTTCAT
TAACTTTGTAGAACCTGCAATCCGCAAGCTACAAGGTCAAACTAACTGGACACCAGTGAAAGCGAACGCGATAGCGACTG
AGCAATTACGTTCTCGTCATGGTCGTACTGAGTTCAGCCGTGGCGTGTTCTCAATGAACGAATCAGGCGTGCTTGAAGTA
AAAACAACCGGTAAGCAAGGTTCAGGTATTCTACGTTCAATGAGCGAAGCAAACTGTCTAATCGAGATTTCACCAGCGGT
AGACACTGTAAAAGCCGGTGAAACGGTGACGATCATTCCTTTGCAAGGTCGTGTGTAA

Upstream 100 bases:

>100_bases
AAGAGTGTGTGACTGAGTACGTCGACTTTAGCGACGCGCCGAACTGCTTTGTTAATCTCAATACGCCAGAAGAACTCACC
CAATTTGGAACGCTTCAATA

Downstream 100 bases:

>100_bases
ATAAACAAGATTGTTAGCTTTAAGCTAGCGAATTCAGAGTAATACATACTCTAAATAGATGAAGCCCCTGATATTGGATA
TCAGGGGCTTTCTTTTTATG

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MKDSKQRPNLPLLGFAAYSGTGKTTVLEALLPLLTNAGLKVGVLKHAHHDFDVDKPGKDSYRLRKAGANQMLIASRNRHV
MMTETPEAEADFDYLLTRFDTNTLDLILVEGCKNIAFPKIELHRDEVGKPWLYQNDDNIIAIAADSQVESDLPQMAINDL
EAIRDFIIDYAQSFDLSSTKGKAASCSSSKDAAPAVCCDSFSPAGLTVTQGQQKIVDSIDALDLTENVELLQGYGRVLAE
DVISPINVPQNTNSAMDGYAIRSEDLELDSYNIVAEVMAGHSYDKTVQQGEAVKIMTGAPMPDGVDVVVMREQAVQDGDK
VSFPDAKISVGQNVRMAGEDLEIGQPVFTRGTRIEAPEMGMMASLGFGTCPVLRKVKVGVFSTGDEVQAPGVEQKPNSIY
DSNRFTIIGMLQKLGCDIVDYGIIEDDEQKMMDVLHAASLETDMVLTSGGVSVGDADYIKLALDKLGEINFWRINMRPGR
PLAYGKIEDKPFFGLPGNPVAVMVSFINFVEPAIRKLQGQTNWTPVKANAIATEQLRSRHGRTEFSRGVFSMNESGVLEV
KTTGKQGSGILRSMSEANCLIEISPAVDTVKAGETVTIIPLQGRV

Sequences:

>Translated_605_residues
MKDSKQRPNLPLLGFAAYSGTGKTTVLEALLPLLTNAGLKVGVLKHAHHDFDVDKPGKDSYRLRKAGANQMLIASRNRHV
MMTETPEAEADFDYLLTRFDTNTLDLILVEGCKNIAFPKIELHRDEVGKPWLYQNDDNIIAIAADSQVESDLPQMAINDL
EAIRDFIIDYAQSFDLSSTKGKAASCSSSKDAAPAVCCDSFSPAGLTVTQGQQKIVDSIDALDLTENVELLQGYGRVLAE
DVISPINVPQNTNSAMDGYAIRSEDLELDSYNIVAEVMAGHSYDKTVQQGEAVKIMTGAPMPDGVDVVVMREQAVQDGDK
VSFPDAKISVGQNVRMAGEDLEIGQPVFTRGTRIEAPEMGMMASLGFGTCPVLRKVKVGVFSTGDEVQAPGVEQKPNSIY
DSNRFTIIGMLQKLGCDIVDYGIIEDDEQKMMDVLHAASLETDMVLTSGGVSVGDADYIKLALDKLGEINFWRINMRPGR
PLAYGKIEDKPFFGLPGNPVAVMVSFINFVEPAIRKLQGQTNWTPVKANAIATEQLRSRHGRTEFSRGVFSMNESGVLEV
KTTGKQGSGILRSMSEANCLIEISPAVDTVKAGETVTIIPLQGRV
>Mature_605_residues
MKDSKQRPNLPLLGFAAYSGTGKTTVLEALLPLLTNAGLKVGVLKHAHHDFDVDKPGKDSYRLRKAGANQMLIASRNRHV
MMTETPEAEADFDYLLTRFDTNTLDLILVEGCKNIAFPKIELHRDEVGKPWLYQNDDNIIAIAADSQVESDLPQMAINDL
EAIRDFIIDYAQSFDLSSTKGKAASCSSSKDAAPAVCCDSFSPAGLTVTQGQQKIVDSIDALDLTENVELLQGYGRVLAE
DVISPINVPQNTNSAMDGYAIRSEDLELDSYNIVAEVMAGHSYDKTVQQGEAVKIMTGAPMPDGVDVVVMREQAVQDGDK
VSFPDAKISVGQNVRMAGEDLEIGQPVFTRGTRIEAPEMGMMASLGFGTCPVLRKVKVGVFSTGDEVQAPGVEQKPNSIY
DSNRFTIIGMLQKLGCDIVDYGIIEDDEQKMMDVLHAASLETDMVLTSGGVSVGDADYIKLALDKLGEINFWRINMRPGR
PLAYGKIEDKPFFGLPGNPVAVMVSFINFVEPAIRKLQGQTNWTPVKANAIATEQLRSRHGRTEFSRGVFSMNESGVLEV
KTTGKQGSGILRSMSEANCLIEISPAVDTVKAGETVTIIPLQGRV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=394, Percent_Identity=33.756345177665, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI10880983, Length=394, Percent_Identity=33.756345177665, Blast_Score=199, Evalue=6e-51,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=42.0365535248042, Blast_Score=319, Evalue=4e-88,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=51.2048192771084, Blast_Score=169, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=369, Percent_Identity=30.6233062330623, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=366, Percent_Identity=26.775956284153, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136978, Length=368, Percent_Identity=32.6086956521739, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24638841, Length=368, Percent_Identity=32.6086956521739, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 65748; Mature: 65748

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDSKQRPNLPLLGFAAYSGTGKTTVLEALLPLLTNAGLKVGVLKHAHHDFDVDKPGKDS
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCC
YRLRKAGANQMLIASRNRHVMMTETPEAEADFDYLLTRFDTNTLDLILVEGCKNIAFPKI
HHHHHCCCCEEEEEECCCEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCEE
ELHRDEVGKPWLYQNDDNIIAIAADSQVESDLPQMAINDLEAIRDFIIDYAQSFDLSSTK
EECCCCCCCCCEEECCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GKAASCSSSKDAAPAVCCDSFSPAGLTVTQGQQKIVDSIDALDLTENVELLQGYGRVLAE
CCCCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DVISPINVPQNTNSAMDGYAIRSEDLELDSYNIVAEVMAGHSYDKTVQQGEAVKIMTGAP
HHHCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCHHHHHHCCCEEEEEECCC
MPDGVDVVVMREQAVQDGDKVSFPDAKISVGQNVRMAGEDLEIGQPVFTRGTRIEAPEMG
CCCCCEEEEEEHHHHCCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHCCCCCCCCCCCC
MMASLGFGTCPVLRKVKVGVFSTGDEVQAPGVEQKPNSIYDSNRFTIIGMLQKLGCDIVD
CHHHCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCEEE
YGIIEDDEQKMMDVLHAASLETDMVLTSGGVSVGDADYIKLALDKLGEINFWRINMRPGR
CCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCC
PLAYGKIEDKPFFGLPGNPVAVMVSFINFVEPAIRKLQGQTNWTPVKANAIATEQLRSRH
CEEECCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHC
GRTEFSRGVFSMNESGVLEVKTTGKQGSGILRSMSEANCLIEISPAVDTVKAGETVTIIP
CCCHHHCCCEECCCCCEEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEE
LQGRV
CCCCC
>Mature Secondary Structure
MKDSKQRPNLPLLGFAAYSGTGKTTVLEALLPLLTNAGLKVGVLKHAHHDFDVDKPGKDS
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCC
YRLRKAGANQMLIASRNRHVMMTETPEAEADFDYLLTRFDTNTLDLILVEGCKNIAFPKI
HHHHHCCCCEEEEEECCCEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCEE
ELHRDEVGKPWLYQNDDNIIAIAADSQVESDLPQMAINDLEAIRDFIIDYAQSFDLSSTK
EECCCCCCCCCEEECCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GKAASCSSSKDAAPAVCCDSFSPAGLTVTQGQQKIVDSIDALDLTENVELLQGYGRVLAE
CCCCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DVISPINVPQNTNSAMDGYAIRSEDLELDSYNIVAEVMAGHSYDKTVQQGEAVKIMTGAP
HHHCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCHHHHHHCCCEEEEEECCC
MPDGVDVVVMREQAVQDGDKVSFPDAKISVGQNVRMAGEDLEIGQPVFTRGTRIEAPEMG
CCCCCEEEEEEHHHHCCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHCCCCCCCCCCCC
MMASLGFGTCPVLRKVKVGVFSTGDEVQAPGVEQKPNSIYDSNRFTIIGMLQKLGCDIVD
CHHHCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCEEE
YGIIEDDEQKMMDVLHAASLETDMVLTSGGVSVGDADYIKLALDKLGEINFWRINMRPGR
CCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCC
PLAYGKIEDKPFFGLPGNPVAVMVSFINFVEPAIRKLQGQTNWTPVKANAIATEQLRSRH
CEEECCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHC
GRTEFSRGVFSMNESGVLEVKTTGKQGSGILRSMSEANCLIEISPAVDTVKAGETVTIIP
CCCHHHCCCEECCCCCEEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEE
LQGRV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]