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The map label for this gene is aroA

Identifier: 218709073

GI number: 218709073

Start: 1135120

End: 1136400

Strand: Direct

Name: aroA

Synonym: VS_1079

Alternate gene names: 218709073

Gene position: 1135120-1136400 (Clockwise)

Preceding gene: 218709072

Following gene: 218709075

Centisome position: 34.4

GC content: 45.12

Gene sequence:

>1281_bases
ATGGAAAGCCTTACGTTACAACCAATTCAGAAAGTGAGCGGGGAAGTTAACCTACCTGGCTCAAAAAGTGTTTCTAATCG
TGCGCTTCTTTTGGCTGCACTTTCAACGGGAACAACTCGCCTAACAAACTTACTAGACAGTGATGACATTCGTCATATGT
TGAATGCATTAACACAGTTAGGTGTTGATTATCAGTTGTCTGCAGACAAAACAGTTTGTGAAGTGACAGGTGTTGGTGGT
GCATTTTCAAGTGACAAAGCCCTAGAGCTTTTCTTAGGTAACGCGGGTACAGCAATGCGTCCATTGGCTGCTGCACTTTG
TTTAGGTCGCGGTGAATACGTTCTTACTGGTGAGCCACGTATGAAAGAGCGCCCAATTGGTCACTTAGTGACTGCACTGA
GAGAAGCCGGTGCCGACGTTGAATACTTAGAAAACGAAAACTATCCACCATTAAAGATCACAGGTACCGGTCTGAAGAGT
GGTACGGTTTCTATCGACGGTTCTATCTCTAGTCAATTCTTGACGGCATTTTTGATGGCTGCACCTTTAGCTGAAGGCGA
AGTGACCATCAAAATCGAGGGTGAATTGGTTTCTAAGCCTTACATCGATATTACGCTGCATATCATGAAGCAATTTGGTG
TGGATGTTATCAACAATGACTACCAAGAATTTGTGATTCCAACCGGGCAATCTTACACAGCACCCGGTGATTTCTTGGTT
GAAGGTGATGCATCATCTGCGTCATATTTCCTTGCAGCCGCTGCTATCAAAGGTGGCGAGATTAAAGTGACAGGTATTGG
CAAAAACAGTATCCAAGGTGATATCCAATTCGCTGATGCACTTGAGAAAATGGGTGCTGAAATTGAATGGGGTGATGACT
ACGTTATCTCTCGTTGTGGTGAGCTAAAAGGCATTGATATGGACTATAACCATATTCCAGATGCGGCGATGACAATTGCG
ACAACGGCTTTGTTTGCTAAGGGAACAACCGCAATCCGCAATGTTTACAACTGGCGTGTGAAAGAGACGGATCGCTTAGC
GGCAATGGCAACAGAACTACGTAAAGTAGGCGCTGAGGTGGAAGAGGGTGAAGACTACATCATTGTTAACCCTGTGGCTG
AACTGACGCACGCGGCGATTGATACTTACGATGATCACCGCATGGCGATGTGTTTCTCATTGGTTGCTTTGAGTGACACC
CCGGTGACGATCAATGATCCAGGTTGTACATCCAAGACATTCCCTGACTACTTCGATAAGCTGAAAATGCTGAGTCTATA
A

Upstream 100 bases:

>100_bases
GTTGGAAAAGTTAGTTAGTCTGCAAGTACGAAGAATTATTCATCACCCGAAAATAAATACGCGCCAGTGACTTCGGGTGG
TACAAGGACTATAAGAACTA

Downstream 100 bases:

>100_bases
AAATACTAAGTCTATAAAAATGATAAGTATATAAAGGTCCAGGAACAAAAAAGCTTGCCTAGATGGCAAGCTTTTTAATT
ATTGCTGAATTGTAAATTCT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MESLTLQPIQKVSGEVNLPGSKSVSNRALLLAALSTGTTRLTNLLDSDDIRHMLNALTQLGVDYQLSADKTVCEVTGVGG
AFSSDKALELFLGNAGTAMRPLAAALCLGRGEYVLTGEPRMKERPIGHLVTALREAGADVEYLENENYPPLKITGTGLKS
GTVSIDGSISSQFLTAFLMAAPLAEGEVTIKIEGELVSKPYIDITLHIMKQFGVDVINNDYQEFVIPTGQSYTAPGDFLV
EGDASSASYFLAAAAIKGGEIKVTGIGKNSIQGDIQFADALEKMGAEIEWGDDYVISRCGELKGIDMDYNHIPDAAMTIA
TTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGAEVEEGEDYIIVNPVAELTHAAIDTYDDHRMAMCFSLVALSDT
PVTINDPGCTSKTFPDYFDKLKMLSL

Sequences:

>Translated_426_residues
MESLTLQPIQKVSGEVNLPGSKSVSNRALLLAALSTGTTRLTNLLDSDDIRHMLNALTQLGVDYQLSADKTVCEVTGVGG
AFSSDKALELFLGNAGTAMRPLAAALCLGRGEYVLTGEPRMKERPIGHLVTALREAGADVEYLENENYPPLKITGTGLKS
GTVSIDGSISSQFLTAFLMAAPLAEGEVTIKIEGELVSKPYIDITLHIMKQFGVDVINNDYQEFVIPTGQSYTAPGDFLV
EGDASSASYFLAAAAIKGGEIKVTGIGKNSIQGDIQFADALEKMGAEIEWGDDYVISRCGELKGIDMDYNHIPDAAMTIA
TTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGAEVEEGEDYIIVNPVAELTHAAIDTYDDHRMAMCFSLVALSDT
PVTINDPGCTSKTFPDYFDKLKMLSL
>Mature_426_residues
MESLTLQPIQKVSGEVNLPGSKSVSNRALLLAALSTGTTRLTNLLDSDDIRHMLNALTQLGVDYQLSADKTVCEVTGVGG
AFSSDKALELFLGNAGTAMRPLAAALCLGRGEYVLTGEPRMKERPIGHLVTALREAGADVEYLENENYPPLKITGTGLKS
GTVSIDGSISSQFLTAFLMAAPLAEGEVTIKIEGELVSKPYIDITLHIMKQFGVDVINNDYQEFVIPTGQSYTAPGDFLV
EGDASSASYFLAAAAIKGGEIKVTGIGKNSIQGDIQFADALEKMGAEIEWGDDYVISRCGELKGIDMDYNHIPDAAMTIA
TTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGAEVEEGEDYIIVNPVAELTHAAIDTYDDHRMAMCFSLVALSDT
PVTINDPGCTSKTFPDYFDKLKMLSL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=425, Percent_Identity=73.4117647058823, Blast_Score=629, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320332, Length=447, Percent_Identity=38.9261744966443, Blast_Score=252, Evalue=9e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_VIBSL (B7VM38)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416694.1
- GeneID:   7160671
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_1079
- HOGENOM:   HBG646626
- OMA:   GADIEWG
- ProtClustDB:   PRK02427
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 45803; Mature: 45803

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLTLQPIQKVSGEVNLPGSKSVSNRALLLAALSTGTTRLTNLLDSDDIRHMLNALTQL
CCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHC
GVDYQLSADKTVCEVTGVGGAFSSDKALELFLGNAGTAMRPLAAALCLGRGEYVLTGEPR
CCCEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCC
MKERPIGHLVTALREAGADVEYLENENYPPLKITGTGLKSGTVSIDGSISSQFLTAFLMA
CCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHH
APLAEGEVTIKIEGELVSKPYIDITLHIMKQFGVDVINNDYQEFVIPTGQSYTAPGDFLV
CCCCCCEEEEEECCEEECCCCHHHHHHHHHHHCCHHHCCCCHHEEEECCCCCCCCCCEEE
EGDASSASYFLAAAAIKGGEIKVTGIGKNSIQGDIQFADALEKMGAEIEWGDDYVISRCG
ECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHCC
ELKGIDMDYNHIPDAAMTIATTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGAEV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCC
EEGEDYIIVNPVAELTHAAIDTYDDHRMAMCFSLVALSDTPVTINDPGCTSKTFPDYFDK
CCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHHEECCCCEEECCCCCCCCCCHHHHHH
LKMLSL
HHHCCC
>Mature Secondary Structure
MESLTLQPIQKVSGEVNLPGSKSVSNRALLLAALSTGTTRLTNLLDSDDIRHMLNALTQL
CCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHC
GVDYQLSADKTVCEVTGVGGAFSSDKALELFLGNAGTAMRPLAAALCLGRGEYVLTGEPR
CCCEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCC
MKERPIGHLVTALREAGADVEYLENENYPPLKITGTGLKSGTVSIDGSISSQFLTAFLMA
CCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHH
APLAEGEVTIKIEGELVSKPYIDITLHIMKQFGVDVINNDYQEFVIPTGQSYTAPGDFLV
CCCCCCEEEEEECCEEECCCCHHHHHHHHHHHCCHHHCCCCHHEEEECCCCCCCCCCEEE
EGDASSASYFLAAAAIKGGEIKVTGIGKNSIQGDIQFADALEKMGAEIEWGDDYVISRCG
ECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHCC
ELKGIDMDYNHIPDAAMTIATTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGAEV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCC
EEGEDYIIVNPVAELTHAAIDTYDDHRMAMCFSLVALSDTPVTINDPGCTSKTFPDYFDK
CCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHHHHEECCCCEEECCCCCCCCCCHHHHHH
LKMLSL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA