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The map label for this gene is clpA [H]

Identifier: 218709068

GI number: 218709068

Start: 1130229

End: 1132502

Strand: Direct

Name: clpA [H]

Synonym: VS_1074

Alternate gene names: 218709068

Gene position: 1130229-1132502 (Clockwise)

Preceding gene: 218709067

Following gene: 218709072

Centisome position: 34.26

GC content: 45.6

Gene sequence:

>2274_bases
ATGCTAAATAAAGAATTAGAGACGAGTTTAAATGGCGCATTTTCTCGTGCGCGAGACAAGCGACATGAATTCATGACTGT
CGAACACCTCCTACTAGCATTATTAGAAAATGATGCGGCCAAGGAAGCGCTCCAAGCTTGTCAGGCTGATCTCGATGCTC
TTCGCAATGAGCTCGATATTTTTATCGACCAAACGACCCCACTTATCCCTGAAAGCGACGAGACTCGTGAAACCCAGCCC
ACGCTGAGCTTTCAACGAGTACTTCAGCGCGCTGTTTTTCATGTTCAATCTTCAGGTCGCAGCGAAGTAACAGGTGCAAA
TGTACTTGTGGCTATTTTTAGTGAGCAAGAATCTCACGCGGCGTATCTTCTTAAGAAAAACGACATCAGCCGCTTAGACA
TAGTGAATTTTATTTCACACGGTATTACCAAAGGCAGCAATGAAGGCGATAGCGGTTCATCTCCTGATTCATTTGGTGGT
GCAGAGAATGCCGAAGAAGCTAACTCAGAAGATCGTCTAGAAAATTTTGCGACCAACCTTAACGAAGTAGCGAAGCAAGG
TAACATTGACCCACTAATTGGTCGTGATAAAGAGCTAGAACGTACCGTTCAAGTTCTGTGTCGTCGTCGTAAGAACAACC
CTCTATTAGTGGGAGAGGCGGGTGTGGGTAAAACTGCTATCGCTGAAGGTCTTGCATGGCGTATCGTTGAAGGCCAAGTC
CCTGAAATTATTCAGAGCAGCGTAATTTACTCTTTGGATATTGGTTCATTACTTGCGGGAACGAAATATCGTGGTGACTT
TGAGAAGCGCTTTAAAGCGATTCTGAAGCAACTCGAGAAAGAAGAAGACGCTATCCTGTTCATCGATGAGATCCATACCA
TTATTGGTGCGGGTGCAGCATCGGGTGGCCAGGTCGATGCGGCAAACCTAATTAAACCGCTATTAAGCAGCGGTAAATTA
CGCTGTATTGGCTCAACCACTTACCAAGAGTACAGCAGTATTTTTGAGAAGGAGCGTGCTTTATCTCGTCGCTTCCAGAA
AATTGATATTGTTGAACCATCGCTAGATGATACAACCAAAATTCTGATTGGCTTGAAGCCAAAATACGAAGCTCACCACG
AAGTACGTTACACCAACAAAGCGTTACGTGCCGCTGTGGAGTTGTCTGCTAAGTATATTAATGAACGTCACCTTCCAGAT
AAGGCGATTGACGTTATTGATGAAGCGGGTGCTCGTAGTCGTTTGGCGCCTGCAAGTCGTCGTAAGAAAACGGTAAGCGT
GGCTGATATTGAGTCAATGGTTGCGAAAATGGCGCGTATTCCTGAGAAGTCAGTATCGTCTTCAGACAAAGATACGCTGC
AGAAACTGGATGACCGCATGAAAATGTTGGTATTCGGACAAGACCCAGCGATCGATGTATTGAGCGAAGCGATCAAGCTA
ACTCGTGCAGGGTTGGGAGCAGACAATAAACCTGTTGGTTCATTCTTGTTTGCTGGCCCTACTGGTGTCGGTAAAACAGA
GGTGACTGTTCAACTGTCTAAATTGATGGGTATTGAGCTTCTGCGCTTTGATATGTCTGAGTACGGTGAGCGTCACTCGG
TAAGCCGCTTGATCGGTGCGCCTCCTGGTTATGTTGGTTATGATCAAGGTGGTCTGCTAACCGATGCTGTTATCAAGAAC
CCACACTCTGTTGTGCTACTTGATGAGATCGAGAAGGCACACCCAGATATCTTTAACTTGTTATTACAGGTGATGGACAA
CGGTACGCTAACCGACAACAACGGTCGCAAAGCAGATTTCCGCAATGTGATCCTAGTGATGACGACCAACGCTGGTGTTG
CAGAAACCGAGAAGAAATCGATCGGTTTGATCCAGCAAGATCATGCGCCAGACGCAATGAGTGAAATTAAGAAGGTATTT
ACTCCTGAGTTCCGTAACCGTCTTGATAATATCATCTGGTTCAACAGCCTTGATCCAAGTGTGATCAGTCAAGTTGTTGA
TAAATTCATTGTTGAGCTTCAGGTCCAACTGGACGCTCGTGGTGTATCTTTAGAGGTTTCTGAGGATGCTCGTCATTGGT
TAGCTGAAAGAGGCTATGACAAGACCATGGGCGCTCGTCCGATGGGACGAGTGATTCAAGAGAAGCTTAAAAAGCCTCTT
GCTAATGAGTTGCTGTTCGGAAGTTTGGTTGACGGCGGTACGGTTAAAGTATCTCTGAAAAAAGACGAACTGGATTTCAT
CTATGTTGGTGCGAAAGAAGAGGTTATGCATTAG

Upstream 100 bases:

>100_bases
GGTAACGATGTACTCAAAGGAAAATGAGCATCCGCTACTATGTACAATGGAGCAAGTGTAAATTGCTCGAACAACACTGT
TGTTCCCTTAGGAGGTACTT

Downstream 100 bases:

>100_bases
GCATACTTCTTAAACACTAACGGCTTATAAAGAGCACTGGGTACAGTTAATTACGATATTAAACGCATGACTTCGGTTGT
GCGTTTTTTTATGCTTGCTA

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MLNKELETSLNGAFSRARDKRHEFMTVEHLLLALLENDAAKEALQACQADLDALRNELDIFIDQTTPLIPESDETRETQP
TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGITKGSNEGDSGSSPDSFGG
AENAEEANSEDRLENFATNLNEVAKQGNIDPLIGRDKELERTVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGQV
PEIIQSSVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEDAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKL
RCIGSTTYQEYSSIFEKERALSRRFQKIDIVEPSLDDTTKILIGLKPKYEAHHEVRYTNKALRAAVELSAKYINERHLPD
KAIDVIDEAGARSRLAPASRRKKTVSVADIESMVAKMARIPEKSVSSSDKDTLQKLDDRMKMLVFGQDPAIDVLSEAIKL
TRAGLGADNKPVGSFLFAGPTGVGKTEVTVQLSKLMGIELLRFDMSEYGERHSVSRLIGAPPGYVGYDQGGLLTDAVIKN
PHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVAETEKKSIGLIQQDHAPDAMSEIKKVF
TPEFRNRLDNIIWFNSLDPSVISQVVDKFIVELQVQLDARGVSLEVSEDARHWLAERGYDKTMGARPMGRVIQEKLKKPL
ANELLFGSLVDGGTVKVSLKKDELDFIYVGAKEEVMH

Sequences:

>Translated_757_residues
MLNKELETSLNGAFSRARDKRHEFMTVEHLLLALLENDAAKEALQACQADLDALRNELDIFIDQTTPLIPESDETRETQP
TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGITKGSNEGDSGSSPDSFGG
AENAEEANSEDRLENFATNLNEVAKQGNIDPLIGRDKELERTVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGQV
PEIIQSSVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEDAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKL
RCIGSTTYQEYSSIFEKERALSRRFQKIDIVEPSLDDTTKILIGLKPKYEAHHEVRYTNKALRAAVELSAKYINERHLPD
KAIDVIDEAGARSRLAPASRRKKTVSVADIESMVAKMARIPEKSVSSSDKDTLQKLDDRMKMLVFGQDPAIDVLSEAIKL
TRAGLGADNKPVGSFLFAGPTGVGKTEVTVQLSKLMGIELLRFDMSEYGERHSVSRLIGAPPGYVGYDQGGLLTDAVIKN
PHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVAETEKKSIGLIQQDHAPDAMSEIKKVF
TPEFRNRLDNIIWFNSLDPSVISQVVDKFIVELQVQLDARGVSLEVSEDARHWLAERGYDKTMGARPMGRVIQEKLKKPL
ANELLFGSLVDGGTVKVSLKKDELDFIYVGAKEEVMH
>Mature_757_residues
MLNKELETSLNGAFSRARDKRHEFMTVEHLLLALLENDAAKEALQACQADLDALRNELDIFIDQTTPLIPESDETRETQP
TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGITKGSNEGDSGSSPDSFGG
AENAEEANSEDRLENFATNLNEVAKQGNIDPLIGRDKELERTVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGQV
PEIIQSSVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEDAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKL
RCIGSTTYQEYSSIFEKERALSRRFQKIDIVEPSLDDTTKILIGLKPKYEAHHEVRYTNKALRAAVELSAKYINERHLPD
KAIDVIDEAGARSRLAPASRRKKTVSVADIESMVAKMARIPEKSVSSSDKDTLQKLDDRMKMLVFGQDPAIDVLSEAIKL
TRAGLGADNKPVGSFLFAGPTGVGKTEVTVQLSKLMGIELLRFDMSEYGERHSVSRLIGAPPGYVGYDQGGLLTDAVIKN
PHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVAETEKKSIGLIQQDHAPDAMSEIKKVF
TPEFRNRLDNIIWFNSLDPSVISQVVDKFIVELQVQLDARGVSLEVSEDARHWLAERGYDKTMGARPMGRVIQEKLKKPL
ANELLFGSLVDGGTVKVSLKKDELDFIYVGAKEEVMH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=29.874213836478, Blast_Score=148, Evalue=2e-35,
Organism=Escherichia coli, GI1787109, Length=750, Percent_Identity=77.6, Blast_Score=1214, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=416, Percent_Identity=41.3461538461538, Blast_Score=291, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=328, Percent_Identity=43.9024390243902, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=411, Percent_Identity=37.956204379562, Blast_Score=264, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83570; Mature: 83570

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKELETSLNGAFSRARDKRHEFMTVEHLLLALLENDAAKEALQACQADLDALRNELDI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHE
FIDQTTPLIPESDETRETQPTLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHA
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
AYLLKKNDISRLDIVNFISHGITKGSNEGDSGSSPDSFGGAENAEEANSEDRLENFATNL
EEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHH
NEVAKQGNIDPLIGRDKELERTVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGQV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCHHEEEECCCC
PEIIQSSVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEDAILFIDEIHTIIGAGAA
HHHHHHHHEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCC
SGGQVDAANLIKPLLSSGKLRCIGSTTYQEYSSIFEKERALSRRFQKIDIVEPSLDDTTK
CCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILIGLKPKYEAHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARSRLAPASR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHH
RKKTVSVADIESMVAKMARIPEKSVSSSDKDTLQKLDDRMKMLVFGQDPAIDVLSEAIKL
HCCEEHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHH
TRAGLGADNKPVGSFLFAGPTGVGKTEVTVQLSKLMGIELLRFDMSEYGERHSVSRLIGA
HHHCCCCCCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
PPGYVGYDQGGLLTDAVIKNPHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADF
CCCCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCCCCC
RNVILVMTTNAGVAETEKKSIGLIQQDHAPDAMSEIKKVFTPEFRNRLDNIIWFNSLDPS
CCEEEEEECCCCCCCCCHHHCCCEECCCCCHHHHHHHHHCCHHHHHHHHHEEEECCCCHH
VISQVVDKFIVELQVQLDARGVSLEVSEDARHWLAERGYDKTMGARPMGRVIQEKLKKPL
HHHHHHHHHHHHHHEEECCCCCEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ANELLFGSLVDGGTVKVSLKKDELDFIYVGAKEEVMH
HHHHHHHHCCCCCEEEEEEECCCCCEEEECCHHHHCC
>Mature Secondary Structure
MLNKELETSLNGAFSRARDKRHEFMTVEHLLLALLENDAAKEALQACQADLDALRNELDI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHE
FIDQTTPLIPESDETRETQPTLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHA
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
AYLLKKNDISRLDIVNFISHGITKGSNEGDSGSSPDSFGGAENAEEANSEDRLENFATNL
EEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHH
NEVAKQGNIDPLIGRDKELERTVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGQV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCHHEEEECCCC
PEIIQSSVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEDAILFIDEIHTIIGAGAA
HHHHHHHHEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCC
SGGQVDAANLIKPLLSSGKLRCIGSTTYQEYSSIFEKERALSRRFQKIDIVEPSLDDTTK
CCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILIGLKPKYEAHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARSRLAPASR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHH
RKKTVSVADIESMVAKMARIPEKSVSSSDKDTLQKLDDRMKMLVFGQDPAIDVLSEAIKL
HCCEEHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHH
TRAGLGADNKPVGSFLFAGPTGVGKTEVTVQLSKLMGIELLRFDMSEYGERHSVSRLIGA
HHHCCCCCCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
PPGYVGYDQGGLLTDAVIKNPHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADF
CCCCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCCCCC
RNVILVMTTNAGVAETEKKSIGLIQQDHAPDAMSEIKKVFTPEFRNRLDNIIWFNSLDPS
CCEEEEEECCCCCCCCCHHHCCCEECCCCCHHHHHHHHHCCHHHHHHHHHEEEECCCCHH
VISQVVDKFIVELQVQLDARGVSLEVSEDARHWLAERGYDKTMGARPMGRVIQEKLKKPL
HHHHHHHHHHHHHHEEECCCCCEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ANELLFGSLVDGGTVKVSLKKDELDFIYVGAKEEVMH
HHHHHHHHCCCCCEEEEEEECCCCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]