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The map label for this gene is grxD [H]

Identifier: 218708958

GI number: 218708958

Start: 993082

End: 993420

Strand: Direct

Name: grxD [H]

Synonym: VS_0962

Alternate gene names: 218708958

Gene position: 993082-993420 (Clockwise)

Preceding gene: 218708954

Following gene: 218708959

Centisome position: 30.1

GC content: 43.66

Gene sequence:

>339_bases
ATGGAAACTATCGATAAAATCAAACAGCAAATTGAAGAAAACACTATTCTACTGTACATGAAAGGTTCTCCTAAGCTACC
TAGCTGTGGTTTCTCTTCTCAAGCGTCTCAAGCGCTAATGGCATGTGGTGAAAAATTTGCTTACGTAGATATCCTACAAA
ACCCTGATATCCGTGCAGAGCTTCCAGCTTACGCACAATGGCCAACGTTCCCACAACTTTGGGTTGAAGGTGAGCTAATC
GGTGGTTGTGATATCATTCTTGAGATGTTCCAAAAGGGTGAGCTTCAGCCAATCGTTAAAGAAGCCGCTGCTAAAGTAGC
TGGCGACGACGCTGAGTAA

Upstream 100 bases:

>100_bases
TTAGCTTAACTGGTTAACCTCTTTTTTTATATGGTTTTTATTCTTTTGGTTTGGGGTAGAATAAAGGCAATGAAAGCCGT
AATCCATTAACGAGGAAGCA

Downstream 100 bases:

>100_bases
GCTTTAGGCCTTGGTGCTTAAATATTGAATGGAAGGGGCCTTAATTAGGCTCCTTTTTTCGTTTGAATGGTTCAACAAAG
ACTCGATAAGGAATGAACAA

Product: putative monothiol glutaredoxin

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
METIDKIKQQIEENTILLYMKGSPKLPSCGFSSQASQALMACGEKFAYVDILQNPDIRAELPAYAQWPTFPQLWVEGELI
GGCDIILEMFQKGELQPIVKEAAAKVAGDDAE

Sequences:

>Translated_112_residues
METIDKIKQQIEENTILLYMKGSPKLPSCGFSSQASQALMACGEKFAYVDILQNPDIRAELPAYAQWPTFPQLWVEGELI
GGCDIILEMFQKGELQPIVKEAAAKVAGDDAE
>Mature_112_residues
METIDKIKQQIEENTILLYMKGSPKLPSCGFSSQASQALMACGEKFAYVDILQNPDIRAELPAYAQWPTFPQLWVEGELI
GGCDIILEMFQKGELQPIVKEAAAKVAGDDAE

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI95113651, Length=96, Percent_Identity=40.625, Blast_Score=92, Evalue=9e-20,
Organism=Homo sapiens, GI42516576, Length=86, Percent_Identity=38.3720930232558, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787943, Length=108, Percent_Identity=75.9259259259259, Blast_Score=182, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17556042, Length=102, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71988153, Length=80, Percent_Identity=40, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988159, Length=80, Percent_Identity=40, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325198, Length=109, Percent_Identity=40.3669724770642, Blast_Score=91, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321022, Length=73, Percent_Identity=46.5753424657534, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320303, Length=73, Percent_Identity=46.5753424657534, Blast_Score=81, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24642023, Length=101, Percent_Identity=39.6039603960396, Blast_Score=95, Evalue=7e-21,
Organism=Drosophila melanogaster, GI19921242, Length=96, Percent_Identity=37.5, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12364; Mature: 12364

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIDKIKQQIEENTILLYMKGSPKLPSCGFSSQASQALMACGEKFAYVDILQNPDIRAE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
LPAYAQWPTFPQLWVEGELIGGCDIILEMFQKGELQPIVKEAAAKVAGDDAE
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
METIDKIKQQIEENTILLYMKGSPKLPSCGFSSQASQALMACGEKFAYVDILQNPDIRAE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
LPAYAQWPTFPQLWVEGELIGGCDIILEMFQKGELQPIVKEAAAKVAGDDAE
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]