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The map label for this gene is 218708941

Identifier: 218708941

GI number: 218708941

Start: 972099

End: 973019

Strand: Direct

Name: 218708941

Synonym: VS_0943

Alternate gene names: NA

Gene position: 972099-973019 (Clockwise)

Preceding gene: 218708938

Following gene: 218708942

Centisome position: 29.46

GC content: 43.87

Gene sequence:

>921_bases
ATGACTCCTTTAATTTACCATCCAATTTATTCTCAGTTGCCTTTACCTGAAGGTCATCGTTACCCAATCAACAAATATCA
GTTGTTACACAGTGCTGTTGAGGCGCTAATGGACAGCGATCCAAAATGGGGTAATGCATTCGAAATGTTCCAGCCAATGC
CTGTTTCGGTAGAACAAGTAAAGCAGGTACACGATGGTGAATATGTCGATTTGCTAGTTTCTGGAAATTTGCCAGCAGCA
AAAATGAGACGTATCGGCTTTCCGTGGAGTGAACAGCTTATAGAAAGGACACTCTATTCAAGTGGTGGAACCTGCTTGGC
CGCTGAAATGGCCATCGAGAGTGGTTTAGCGATTCATCTCAGCGGTGGCTATCATCATGCGCACCGAGATTTTGGCAGTG
GCTTCTGTTTGTTGAATGATCTGGTCTTGGCGGCCAAGCACGCATTAACCTTTGAGCATATAGATAAAGTGCTTATCGTC
GACAGTGATGTTCACCATGGCGATGGTACAGCGACACTTTGCCAAGAGAGCGATGAGATTATTACTCTGTCATTCCACTG
CGATAAGAACTTCCCTGCGCGTAAACCGTTATCTGATTTAGATGTGCCATTAAGTCGTGAAACAGAAGATGAAGAGTTTT
TGCGTTGTTTTGAACAAGTCACTAAGTTAGCGATTGCTCACCATCAACCAGATCTGATTATTTATGATGCGGGGATCGAT
ATCCATCAAGACGATGAACTGGGTTATTTGAATGTTTCGACAAAAGGGATATTTGAACGCGACTGTTTCATGATTGAATT
AGCGAAATCAGAGTCTATTCCAATGGCGTGTGTAGTCGGTGGCGGATATCGAACTGAACATCAAGATCTGGTGCCGATTC
ACATGCAGTTACTCAACGCTGCATTGGCTGTGAATAGCTGA

Upstream 100 bases:

>100_bases
GAATCAATTAAAGGTAATGATAACTATTATCATTAATTAAGGTTGTCGCCAAGTATGAGACTGTTATGATTTTGAGATTG
ATACGTAATACGCCCGATCT

Downstream 100 bases:

>100_bases
ACCGTTGAGCTCCGTGATCTCCAGATACAAAAAAGCCGCTGATTTCTCAGCGGCTTTCTTTAATGTGGTGGAGGGATAGG
GATTTGAACCCTAGAACCGC

Product: histone deacetylase/AcuC/AphA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTPLIYHPIYSQLPLPEGHRYPINKYQLLHSAVEALMDSDPKWGNAFEMFQPMPVSVEQVKQVHDGEYVDLLVSGNLPAA
KMRRIGFPWSEQLIERTLYSSGGTCLAAEMAIESGLAIHLSGGYHHAHRDFGSGFCLLNDLVLAAKHALTFEHIDKVLIV
DSDVHHGDGTATLCQESDEIITLSFHCDKNFPARKPLSDLDVPLSRETEDEEFLRCFEQVTKLAIAHHQPDLIIYDAGID
IHQDDELGYLNVSTKGIFERDCFMIELAKSESIPMACVVGGGYRTEHQDLVPIHMQLLNAALAVNS

Sequences:

>Translated_306_residues
MTPLIYHPIYSQLPLPEGHRYPINKYQLLHSAVEALMDSDPKWGNAFEMFQPMPVSVEQVKQVHDGEYVDLLVSGNLPAA
KMRRIGFPWSEQLIERTLYSSGGTCLAAEMAIESGLAIHLSGGYHHAHRDFGSGFCLLNDLVLAAKHALTFEHIDKVLIV
DSDVHHGDGTATLCQESDEIITLSFHCDKNFPARKPLSDLDVPLSRETEDEEFLRCFEQVTKLAIAHHQPDLIIYDAGID
IHQDDELGYLNVSTKGIFERDCFMIELAKSESIPMACVVGGGYRTEHQDLVPIHMQLLNAALAVNS
>Mature_305_residues
TPLIYHPIYSQLPLPEGHRYPINKYQLLHSAVEALMDSDPKWGNAFEMFQPMPVSVEQVKQVHDGEYVDLLVSGNLPAAK
MRRIGFPWSEQLIERTLYSSGGTCLAAEMAIESGLAIHLSGGYHHAHRDFGSGFCLLNDLVLAAKHALTFEHIDKVLIVD
SDVHHGDGTATLCQESDEIITLSFHCDKNFPARKPLSDLDVPLSRETEDEEFLRCFEQVTKLAIAHHQPDLIIYDAGIDI
HQDDELGYLNVSTKGIFERDCFMIELAKSESIPMACVVGGGYRTEHQDLVPIHMQLLNAALAVNS

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI217272877, Length=299, Percent_Identity=27.4247491638796, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI209862883, Length=255, Percent_Identity=28.6274509803922, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI13128860, Length=258, Percent_Identity=29.8449612403101, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI293336691, Length=231, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI13128862, Length=261, Percent_Identity=29.1187739463602, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI8923769, Length=283, Percent_Identity=25.4416961130742, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073092, Length=219, Percent_Identity=27.3972602739726, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI13128864, Length=262, Percent_Identity=25.9541984732824, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508561, Length=259, Percent_Identity=32.046332046332, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17561978, Length=258, Percent_Identity=31.7829457364341, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI193207430, Length=319, Percent_Identity=25.705329153605, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17534739, Length=199, Percent_Identity=31.6582914572864, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17540332, Length=145, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193206283, Length=145, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=145, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537347, Length=172, Percent_Identity=30.2325581395349, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=146, Percent_Identity=32.8767123287671, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25154020, Length=146, Percent_Identity=32.8767123287671, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323999, Length=259, Percent_Identity=32.046332046332, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321244, Length=260, Percent_Identity=28.8461538461538, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6325325, Length=179, Percent_Identity=29.608938547486, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24649807, Length=247, Percent_Identity=27.5303643724696, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24657891, Length=258, Percent_Identity=29.8449612403101, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644244, Length=263, Percent_Identity=25.8555133079848, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360899, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642144, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642142, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642146, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 34146; Mature: 34015

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLIYHPIYSQLPLPEGHRYPINKYQLLHSAVEALMDSDPKWGNAFEMFQPMPVSVEQV
CCCEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHH
KQVHDGEYVDLLVSGNLPAAKMRRIGFPWSEQLIERTLYSSGGTCLAAEMAIESGLAIHL
HHHCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEHHHCCCEEEE
SGGYHHAHRDFGSGFCLLNDLVLAAKHALTFEHIDKVLIVDSDVHHGDGTATLCQESDEI
ECCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCCE
ITLSFHCDKNFPARKPLSDLDVPLSRETEDEEFLRCFEQVTKLAIAHHQPDLIIYDAGID
EEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
IHQDDELGYLNVSTKGIFERDCFMIELAKSESIPMACVVGGGYRTEHQDLVPIHMQLLNA
EECCCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
ALAVNS
HHHCCC
>Mature Secondary Structure 
TPLIYHPIYSQLPLPEGHRYPINKYQLLHSAVEALMDSDPKWGNAFEMFQPMPVSVEQV
CCEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHH
KQVHDGEYVDLLVSGNLPAAKMRRIGFPWSEQLIERTLYSSGGTCLAAEMAIESGLAIHL
HHHCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEHHHCCCEEEE
SGGYHHAHRDFGSGFCLLNDLVLAAKHALTFEHIDKVLIVDSDVHHGDGTATLCQESDEI
ECCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCCE
ITLSFHCDKNFPARKPLSDLDVPLSRETEDEEFLRCFEQVTKLAIAHHQPDLIIYDAGID
EEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
IHQDDELGYLNVSTKGIFERDCFMIELAKSESIPMACVVGGGYRTEHQDLVPIHMQLLNA
EECCCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
ALAVNS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7678591 [H]