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The map label for this gene is fadH [H]

Identifier: 218708936

GI number: 218708936

Start: 965222

End: 967234

Strand: Direct

Name: fadH [H]

Synonym: VS_0938

Alternate gene names: 218708936

Gene position: 965222-967234 (Clockwise)

Preceding gene: 218708933

Following gene: 218708937

Centisome position: 29.26

GC content: 47.59

Gene sequence:

>2013_bases
GTGATGTCTGCCATGTACCCACATTTACTCGAACCACTCGATCTTGGATTTACTCAGCTACGTAACCGTGTATTGATGGG
ATCAATGCACACGGGTTTAGAAGAAAATAAAGAAGGCCTCCACAAGCTTGCCGCGTTTTATGAAGAGCGAGCAAAAGGAG
GCGTTGGCCTTATTGTTACCGGTGGTTTCTCTCCTAATTTACGTGGCAGATTGACCCCATTTAGTGCTGAGTTCAGTAAA
GTTAAGCACGCTAAAGCTCACCAAGTTGTTACCGAGGCCGTGCATAAGCATGGAGGTAAAATTGCCCTTCAGTTGCTACA
TGCTGGCCGCTATGCCATGCACCCATTCGCGCAAAGTGCTTCGGGCATCAAAGCGCCAATCGCTAAGTTTGCACCGAGTG
AGATGAGCCCTCGTCAAATTAAAAAGACCATCGGTGCTTTTGCCAACAGTGCAGAGCTAGCTCAGGTTGCTGGCTATGAC
GGCATAGAGATCATGGGCTCCGAAGGTTACTTGATTAACCAATTTATCTGTAAACGTACCAACATGCGTTATGACGAATG
GGGCGGTTCTTATGAGAAGCGTATGCGTTTCCCGCTAGAGATCGTTAAATCGATTCGCGAAGCGGTGGGTAAAGATTTCA
TCATTATTTTCCGTTTATCGATGCTGGATTTGGTTGAGCAAGGCAGCACATTCGAAGATGTTGTACTTCTGGCTCAGAAG
CTAGAAGAAGCGGGCGTGACCATTATTAATACCGGTATTGGTTGGCATGAAGCTCGTGTCCCAACTATTGCGACACAAGT
TCCAAGAGGGGCATTCTCTTGGGTGACGGAAAAAGTAAAACCATACGTGTCGATCCCAGTGGTGACGTGTAACCGAATCA
ACACGCCAGAAGAGGCCGAACGTATCCTCAGTTCAGGACAGGCCGACATGGTATCAATGGCTCGTCCATTCTTGGCTGAC
CCTGACTTTGTTAATAAAGCCGCTCAAGACCAAGCGCAGTTCATTAACACCTGTATCGGTTGTAACCAAGCGTGTCTTGA
TAACGTATTCAAAGGCAAACGAGCGAGCTGCTTGGTGAATCCTCGCGCTTGTTACGAAACTGAAATTGTTGTGCAACCAG
CTCAAGCAACCAAAACCATTGCCGTCGTCGGTGCTGGGCCAGCAGGTTTAGCTTGTGCAACAACGTTGGCACAGCGTGGG
CATAAGGTTGATCTGATAGAGAAAAATGACCGCATCGGTGGACAATTTAGATTGGCAATGCAGATTCCGGGTAAAGAAGA
GTTCAGAGAAACGATTCGTTACTTTGCTAACCAAATAGATGCATCAGGCGTGAACTTAAAACTGGATACTGAAGCGACGT
TTGAGATGTTGTTGAAGTACGATGAAGTCGTGATGGCTGCTGGTGTTGAACCCAGAAAGCTTGATATTGAAGGGATAGAT
CAAGAAAACGTAGTCGACTACCAAACCTTGATTCGTGAAAAGACACCAGTAGGCGAAAAAGTCGCGATTGTTGGTGCCGG
TGGTATTGGTATTGATGTGGCAACTATGCTGACAGAGCCGACTTCTCATAGCTTGGACGACTGGCTGCATGAGTGGGGCA
TTGATAAGAATATGGAGCACCCAGGTGGACTTTATCCTTACCCTGATTCGTTCAGTGATAAAACGGTTTGGGTGATGCAG
CGTAAAGCCGGTCGAGTGGGTAAAGGCCCGGGTAAGACTACAGGTTGGATTCATAAACGCACATTAGAAAAACGTGGTGT
GAACTTACTTGGTGGCGTGAGCTACAACAAGATTGACGACCAAGGTCTGCATATTAGCGTTGGTAAGAAAGATCAGGTAC
TCGATGCCGATTCCGTTATCGTGTGTGCGGGCCAAGTTTCGGTTCGTCCATTCGAAGACATGTGGCAAGAGTTTGGTGGC
AAACTGCACGTGATAGGCGGTGCCGATTACGCGGGTGAACTGGATGCCGTGCGTGCGATTCGCCAAGGTGTTGAGTTAGC
TATTAAGCTTTAA

Upstream 100 bases:

>100_bases
GTCCTGCATTATGATCGGTGTTACAAAAATGTAAACGGTTGTTTGAACTTTTGGTGATTGAGTTATATTGTGGTCTGACC
ACAAGGATATAATAATAGAA

Downstream 100 bases:

>100_bases
CAACAAACAGAATGTTCTCGGTCATAAACCTGAACGAAACCTGTAAATAAGGCTCCTAAGTCATAGATTTAGGAGCCTTT
ATTGTTTCCAGTATTGTTTG

Product: 2,4-dienoyl-CoA reductase [NADPH]

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MMSAMYPHLLEPLDLGFTQLRNRVLMGSMHTGLEENKEGLHKLAAFYEERAKGGVGLIVTGGFSPNLRGRLTPFSAEFSK
VKHAKAHQVVTEAVHKHGGKIALQLLHAGRYAMHPFAQSASGIKAPIAKFAPSEMSPRQIKKTIGAFANSAELAQVAGYD
GIEIMGSEGYLINQFICKRTNMRYDEWGGSYEKRMRFPLEIVKSIREAVGKDFIIIFRLSMLDLVEQGSTFEDVVLLAQK
LEEAGVTIINTGIGWHEARVPTIATQVPRGAFSWVTEKVKPYVSIPVVTCNRINTPEEAERILSSGQADMVSMARPFLAD
PDFVNKAAQDQAQFINTCIGCNQACLDNVFKGKRASCLVNPRACYETEIVVQPAQATKTIAVVGAGPAGLACATTLAQRG
HKVDLIEKNDRIGGQFRLAMQIPGKEEFRETIRYFANQIDASGVNLKLDTEATFEMLLKYDEVVMAAGVEPRKLDIEGID
QENVVDYQTLIREKTPVGEKVAIVGAGGIGIDVATMLTEPTSHSLDDWLHEWGIDKNMEHPGGLYPYPDSFSDKTVWVMQ
RKAGRVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYNKIDDQGLHISVGKKDQVLDADSVIVCAGQVSVRPFEDMWQEFGG
KLHVIGGADYAGELDAVRAIRQGVELAIKL

Sequences:

>Translated_670_residues
MMSAMYPHLLEPLDLGFTQLRNRVLMGSMHTGLEENKEGLHKLAAFYEERAKGGVGLIVTGGFSPNLRGRLTPFSAEFSK
VKHAKAHQVVTEAVHKHGGKIALQLLHAGRYAMHPFAQSASGIKAPIAKFAPSEMSPRQIKKTIGAFANSAELAQVAGYD
GIEIMGSEGYLINQFICKRTNMRYDEWGGSYEKRMRFPLEIVKSIREAVGKDFIIIFRLSMLDLVEQGSTFEDVVLLAQK
LEEAGVTIINTGIGWHEARVPTIATQVPRGAFSWVTEKVKPYVSIPVVTCNRINTPEEAERILSSGQADMVSMARPFLAD
PDFVNKAAQDQAQFINTCIGCNQACLDNVFKGKRASCLVNPRACYETEIVVQPAQATKTIAVVGAGPAGLACATTLAQRG
HKVDLIEKNDRIGGQFRLAMQIPGKEEFRETIRYFANQIDASGVNLKLDTEATFEMLLKYDEVVMAAGVEPRKLDIEGID
QENVVDYQTLIREKTPVGEKVAIVGAGGIGIDVATMLTEPTSHSLDDWLHEWGIDKNMEHPGGLYPYPDSFSDKTVWVMQ
RKAGRVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYNKIDDQGLHISVGKKDQVLDADSVIVCAGQVSVRPFEDMWQEFGG
KLHVIGGADYAGELDAVRAIRQGVELAIKL
>Mature_670_residues
MMSAMYPHLLEPLDLGFTQLRNRVLMGSMHTGLEENKEGLHKLAAFYEERAKGGVGLIVTGGFSPNLRGRLTPFSAEFSK
VKHAKAHQVVTEAVHKHGGKIALQLLHAGRYAMHPFAQSASGIKAPIAKFAPSEMSPRQIKKTIGAFANSAELAQVAGYD
GIEIMGSEGYLINQFICKRTNMRYDEWGGSYEKRMRFPLEIVKSIREAVGKDFIIIFRLSMLDLVEQGSTFEDVVLLAQK
LEEAGVTIINTGIGWHEARVPTIATQVPRGAFSWVTEKVKPYVSIPVVTCNRINTPEEAERILSSGQADMVSMARPFLAD
PDFVNKAAQDQAQFINTCIGCNQACLDNVFKGKRASCLVNPRACYETEIVVQPAQATKTIAVVGAGPAGLACATTLAQRG
HKVDLIEKNDRIGGQFRLAMQIPGKEEFRETIRYFANQIDASGVNLKLDTEATFEMLLKYDEVVMAAGVEPRKLDIEGID
QENVVDYQTLIREKTPVGEKVAIVGAGGIGIDVATMLTEPTSHSLDDWLHEWGIDKNMEHPGGLYPYPDSFSDKTVWVMQ
RKAGRVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYNKIDDQGLHISVGKKDQVLDADSVIVCAGQVSVRPFEDMWQEFGG
KLHVIGGADYAGELDAVRAIRQGVELAIKL

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=670, Percent_Identity=55.6716417910448, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI1787939, Length=349, Percent_Identity=26.647564469914, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559802, Length=250, Percent_Identity=29.6, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17559804, Length=253, Percent_Identity=29.2490118577075, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565138, Length=330, Percent_Identity=26.3636363636364, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17566914, Length=340, Percent_Identity=27.0588235294118, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17564188, Length=247, Percent_Identity=28.3400809716599, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI72001454, Length=248, Percent_Identity=28.2258064516129, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17540738, Length=305, Percent_Identity=25.2459016393443, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325086, Length=243, Percent_Identity=28.8065843621399, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321973, Length=353, Percent_Identity=23.7960339943343, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320030, Length=155, Percent_Identity=33.5483870967742, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 73482; Mature: 73482

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSAMYPHLLEPLDLGFTQLRNRVLMGSMHTGLEENKEGLHKLAAFYEERAKGGVGLIVT
CCCCCCHHHHCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
GGFSPNLRGRLTPFSAEFSKVKHAKAHQVVTEAVHKHGGKIALQLLHAGRYAMHPFAQSA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCHHHCHHHHCC
SGIKAPIAKFAPSEMSPRQIKKTIGAFANSAELAQVAGYDGIEIMGSEGYLINQFICKRT
CCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHC
NMRYDEWGGSYEKRMRFPLEIVKSIREAVGKDFIIIFRLSMLDLVEQGSTFEDVVLLAQK
CCCHHHCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHH
LEEAGVTIINTGIGWHEARVPTIATQVPRGAFSWVTEKVKPYVSIPVVTCNRINTPEEAE
HHHCCCEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHHH
RILSSGQADMVSMARPFLADPDFVNKAAQDQAQFINTCIGCNQACLDNVFKGKRASCLVN
HHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEC
PRACYETEIVVQPAQATKTIAVVGAGPAGLACATTLAQRGHKVDLIEKNDRIGGQFRLAM
CHHHCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEE
QIPGKEEFRETIRYFANQIDASGVNLKLDTEATFEMLLKYDEVVMAAGVEPRKLDIEGID
ECCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEECCCCCC
QENVVDYQTLIREKTPVGEKVAIVGAGGIGIDVATMLTEPTSHSLDDWLHEWGIDKNMEH
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCC
PGGLYPYPDSFSDKTVWVMQRKAGRVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYNKIDD
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCC
QGLHISVGKKDQVLDADSVIVCAGQVSVRPFEDMWQEFGGKLHVIGGADYAGELDAVRAI
CCCEEEECCCCCEECCCCEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHH
RQGVELAIKL
HHCHHEEEEC
>Mature Secondary Structure
MMSAMYPHLLEPLDLGFTQLRNRVLMGSMHTGLEENKEGLHKLAAFYEERAKGGVGLIVT
CCCCCCHHHHCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
GGFSPNLRGRLTPFSAEFSKVKHAKAHQVVTEAVHKHGGKIALQLLHAGRYAMHPFAQSA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCHHHCHHHHCC
SGIKAPIAKFAPSEMSPRQIKKTIGAFANSAELAQVAGYDGIEIMGSEGYLINQFICKRT
CCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCCHHHHHHHHC
NMRYDEWGGSYEKRMRFPLEIVKSIREAVGKDFIIIFRLSMLDLVEQGSTFEDVVLLAQK
CCCHHHCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHH
LEEAGVTIINTGIGWHEARVPTIATQVPRGAFSWVTEKVKPYVSIPVVTCNRINTPEEAE
HHHCCCEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHHH
RILSSGQADMVSMARPFLADPDFVNKAAQDQAQFINTCIGCNQACLDNVFKGKRASCLVN
HHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEC
PRACYETEIVVQPAQATKTIAVVGAGPAGLACATTLAQRGHKVDLIEKNDRIGGQFRLAM
CHHHCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEE
QIPGKEEFRETIRYFANQIDASGVNLKLDTEATFEMLLKYDEVVMAAGVEPRKLDIEGID
ECCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEECCCCCC
QENVVDYQTLIREKTPVGEKVAIVGAGGIGIDVATMLTEPTSHSLDDWLHEWGIDKNMEH
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCC
PGGLYPYPDSFSDKTVWVMQRKAGRVGKGPGKTTGWIHKRTLEKRGVNLLGGVSYNKIDD
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCC
QGLHISVGKKDQVLDADSVIVCAGQVSVRPFEDMWQEFGGKLHVIGGADYAGELDAVRAI
CCCEEEECCCCCEECCCCEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHH
RQGVELAIKL
HHCHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]