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The map label for this gene is rppH [H]

Identifier: 218708557

GI number: 218708557

Start: 541677

End: 542195

Strand: Direct

Name: rppH [H]

Synonym: VS_0523

Alternate gene names: 218708557

Gene position: 541677-542195 (Clockwise)

Preceding gene: 218708555

Following gene: 218708558

Centisome position: 16.42

GC content: 44.32

Gene sequence:

>519_bases
GTGATAGATGGCGATGGTTACCGATTAAATGTTGGTATTGTAATCTGTAACAACCATGGTCAGGTCTTCTGGGCTAAACG
ATACGGGCAACATTCATGGCAATTCCCTCAAGGGGGAATAGATGAAGGTGAAACTCCGGAACAGGCAATGTACCGCGAGT
TGTATGAAGAGGTTGGCCTTACTAAAAAGGATGTAAAGATCGTCGCGACAAGTCGTCATTGGTTACGCTATAAGCTGCCC
AAACGACTGGTTCGGTGGGATTCTAAACCTGTCTGTATTGGACAAAAACAGAAGTGGTTTCTTTTACGCTTAGATTGCGA
TGAATCGCATATCAATATGCAGCGTGGAAGCACACCTGAGTTTGATGGTTGGCGTTGGGTGAGTTACTGGTACCCAGTTC
GACAAGTTGTATCTTTCAAGCGAGATGTTTACCGTCGAGCGATGAAAGAATTCGCATCTTTAGCAATGCCGTTTAAAGAG
CGAAAAACAAAAGGAAAGCGCAAATTGCGTAGAGGTTAA

Upstream 100 bases:

>100_bases
ATTATTCATAAATATAGCGCTTGTCACGTCACTAAGTTTGCTCCGATTGGGGATATGTGGAAAAATCAGTGTAATTAAAA
ATTTAGATAGAGGTTGGCCA

Downstream 100 bases:

>100_bases
GCATGCTCAGCCAACTAAGGGAAATAGTTGAACACGTATCAAGAGTTGAAGATGTGTCGACGGCTCTTGATATTTTGGTT
AAAGAGACATGCAGCGCGAT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MIDGDGYRLNVGIVICNNHGQVFWAKRYGQHSWQFPQGGIDEGETPEQAMYRELYEEVGLTKKDVKIVATSRHWLRYKLP
KRLVRWDSKPVCIGQKQKWFLLRLDCDESHINMQRGSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRAMKEFASLAMPFKE
RKTKGKRKLRRG

Sequences:

>Translated_172_residues
MIDGDGYRLNVGIVICNNHGQVFWAKRYGQHSWQFPQGGIDEGETPEQAMYRELYEEVGLTKKDVKIVATSRHWLRYKLP
KRLVRWDSKPVCIGQKQKWFLLRLDCDESHINMQRGSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRAMKEFASLAMPFKE
RKTKGKRKLRRG
>Mature_172_residues
MIDGDGYRLNVGIVICNNHGQVFWAKRYGQHSWQFPQGGIDEGETPEQAMYRELYEEVGLTKKDVKIVATSRHWLRYKLP
KRLVRWDSKPVCIGQKQKWFLLRLDCDESHINMQRGSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRAMKEFASLAMPFKE
RKTKGKRKLRRG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=164, Percent_Identity=76.8292682926829, Blast_Score=275, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20589; Mature: 20589

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDGDGYRLNVGIVICNNHGQVFWAKRYGQHSWQFPQGGIDEGETPEQAMYRELYEEVGL
CCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TKKDVKIVATSRHWLRYKLPKRLVRWDSKPVCIGQKQKWFLLRLDCDESHINMQRGSTPE
CHHHEEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCC
FDGWRWVSYWYPVRQVVSFKRDVYRRAMKEFASLAMPFKERKTKGKRKLRRG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDGDGYRLNVGIVICNNHGQVFWAKRYGQHSWQFPQGGIDEGETPEQAMYRELYEEVGL
CCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TKKDVKIVATSRHWLRYKLPKRLVRWDSKPVCIGQKQKWFLLRLDCDESHINMQRGSTPE
CHHHEEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCC
FDGWRWVSYWYPVRQVVSFKRDVYRRAMKEFASLAMPFKERKTKGKRKLRRG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]