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The map label for this gene is murC

Identifier: 218708487

GI number: 218708487

Start: 462203

End: 463663

Strand: Direct

Name: murC

Synonym: VS_0451

Alternate gene names: 218708487

Gene position: 462203-463663 (Clockwise)

Preceding gene: 218708486

Following gene: 218708488

Centisome position: 14.01

GC content: 47.09

Gene sequence:

>1461_bases
ATGACGATTGAACATACCCAAGACTTAGCGCAAATCCGTGCAATGGTGCCAGAGATGCGCCGTGTTAAATCTATCCACTT
CATTGGTATTGGTGGTGCCGGAATGAGCGGGATTGCTGAAGTCTTGCTTAATGAAGGCTACCAGATCACAGGTTCTGATA
TTGCTCAAAACCCAGTGACAGAACGCTTAGTTAGCAAGGGGGCTACTGTTTACGTTGGTCACCAAGCGAGTAACGTTGCC
GACGCAAGTGTGGTGGTGGTTTCAACCGCTATCAACGAAGAAAACCCAGAAATTATTGCAGCTCGTGAAGCGCGCACACC
GATCGTTCGTCGTGCAGAAATGCTGGCTGAGCTAATGCGTTTTCGTCACGGTATTGCTGTGGCAGGTACGCACGGTAAAA
CAACCACGACTGCGCTAGTGACACAGATTTACTCGGAAGCAGGCCTAGATCCAACTTTCGTAAACGGTGGTTTGGTTAAA
AGTGCAGGTACTAACGCACGTTTAGGTTCGAGCCGTATTCTTATCGCTGAAGCAGATGAAAGTGATGCGTCATTCTTACA
TCTGCAACCAATGGTTAGTATCGTCACTAACATTGAAGCGGATCATATGGACACTTACGGCGGCGATTTTGAAACGCTGA
AGCAGACGTTTATTGATTTCTTACACAACCTACCATTCTACGGTCAGGCTGTGATGTGTGTTGATGATCCTGTAGTGCGT
GAGCTTATTCCTCAGGTTAGCCGCCAAGTGATTACTTACGGTTTCTCAGAAGATGCGGATATTCGTATTGAGAACTACGT
GCAAGAAGGCCAGCAAGGCAAGTTCACGGTGGTACGTGAAGGTAAAGCTAACCTTGATATCACGTTAAACATTCCGGGTC
GTCACAATGCATTGAATGCCTCAGCAGCGATTGCTGTTGCAACAGAAGATGACATTAGCGATGAAGCGATTCTAAAAGCG
ATGGCGGGAACCGAAGGTACGGGTCGTCGTTTTGATCATCTAGGTGAGTACGAAACAGGTAAAGGCGTTGCAATGCTGGT
CGATGATTACGGTCATCACCCAACCGAAGTGGACGTAACCATTCAAGCAGCACGAAGTGGTTGGACTGATAAGCGTCTTG
TTATGATCTTCCAACCGCACCGTTACAGCCGTACTCGTGATCTATATGATGATTTTGCGAATGTTCTTGAGCAAGTTGAT
GTACTTATTCTATTAGATGTTTATTCTGCAGGTGAGAAACCCATTGCAGGGGCTGACGGGCGTTCATTAAGTCGAACTAT
TCGCGGGCGTGGTAAGATAGATCCAATCTTTGTTGCCGATATCAACGCACTGCCATCGGCTTTAGCCAACGTAATTCAAG
GTGGTGACCTTGTTTTAACGCAGGGTGCGGGCGATGTTGGCCGAGTAGCGAAGCAGTTGGAATCATTGCAGTTAGACATT
AATAAGATGCAGAACGCGTAA

Upstream 100 bases:

>100_bases
AAAATGATGGCAACAAAAGCTCGTCAAGCCGCCAAGCTTGATGCTGATGTGACTGTCGCTGAAGCGATTAAAGCTTTAGC
AAAATAATGAGATTGAATTG

Downstream 100 bases:

>100_bases
CAGAATACTGTCTACAGACTGTGGTCAATCGCTCACTTCTTGCGATTGACCTAAAATTGACCAAAAATCTTATTATCAAC
GTTTGATAGTTTAATTTTGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTIEHTQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAQNPVTERLVSKGATVYVGHQASNVA
DASVVVVSTAINEENPEIIAAREARTPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
SAGTNARLGSSRILIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
ELIPQVSRQVITYGFSEDADIRIENYVQEGQQGKFTVVREGKANLDITLNIPGRHNALNASAAIAVATEDDISDEAILKA
MAGTEGTGRRFDHLGEYETGKGVAMLVDDYGHHPTEVDVTIQAARSGWTDKRLVMIFQPHRYSRTRDLYDDFANVLEQVD
VLILLDVYSAGEKPIAGADGRSLSRTIRGRGKIDPIFVADINALPSALANVIQGGDLVLTQGAGDVGRVAKQLESLQLDI
NKMQNA

Sequences:

>Translated_486_residues
MTIEHTQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAQNPVTERLVSKGATVYVGHQASNVA
DASVVVVSTAINEENPEIIAAREARTPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
SAGTNARLGSSRILIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
ELIPQVSRQVITYGFSEDADIRIENYVQEGQQGKFTVVREGKANLDITLNIPGRHNALNASAAIAVATEDDISDEAILKA
MAGTEGTGRRFDHLGEYETGKGVAMLVDDYGHHPTEVDVTIQAARSGWTDKRLVMIFQPHRYSRTRDLYDDFANVLEQVD
VLILLDVYSAGEKPIAGADGRSLSRTIRGRGKIDPIFVADINALPSALANVIQGGDLVLTQGAGDVGRVAKQLESLQLDI
NKMQNA
>Mature_485_residues
TIEHTQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAQNPVTERLVSKGATVYVGHQASNVAD
ASVVVVSTAINEENPEIIAAREARTPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKS
AGTNARLGSSRILIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVRE
LIPQVSRQVITYGFSEDADIRIENYVQEGQQGKFTVVREGKANLDITLNIPGRHNALNASAAIAVATEDDISDEAILKAM
AGTEGTGRRFDHLGEYETGKGVAMLVDDYGHHPTEVDVTIQAARSGWTDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDV
LILLDVYSAGEKPIAGADGRSLSRTIRGRGKIDPIFVADINALPSALANVIQGGDLVLTQGAGDVGRVAKQLESLQLDIN
KMQNA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=479, Percent_Identity=71.1899791231733, Blast_Score=656, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=468, Percent_Identity=26.9230769230769, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_VIBSL (B7VJ04)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416108.1
- GeneID:   7160086
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0451
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52609; Mature: 52478

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEHTQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAQNPVT
CCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHCCCCEECCCHHHCCHHH
ERLVSKGATVYVGHQASNVADASVVVVSTAINEENPEIIAAREARTPIVRRAEMLAELMR
HHHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHH
FRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADE
HHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELIPQVSRQVITYGFSEDADIRIENYVQEGQQGKFTVVREGKANLDITLNIPGRHNALNA
HHHHHHHHHHEEECCCCCCCEEEHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCCC
SAAIAVATEDDISDEAILKAMAGTEGTGRRFDHLGEYETGKGVAMLVDDYGHHPTEVDVT
CEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCEEEEE
IQAARSGWTDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDVLILLDVYSAGEKPIAGADG
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCC
RSLSRTIRGRGKIDPIFVADINALPSALANVIQGGDLVLTQGAGDVGRVAKQLESLQLDI
CHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
NKMQNA
HHHCCC
>Mature Secondary Structure 
TIEHTQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAQNPVT
CCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHCCCCEECCCHHHCCHHH
ERLVSKGATVYVGHQASNVADASVVVVSTAINEENPEIIAAREARTPIVRRAEMLAELMR
HHHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHH
FRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADE
HHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELIPQVSRQVITYGFSEDADIRIENYVQEGQQGKFTVVREGKANLDITLNIPGRHNALNA
HHHHHHHHHHEEECCCCCCCEEEHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCCC
SAAIAVATEDDISDEAILKAMAGTEGTGRRFDHLGEYETGKGVAMLVDDYGHHPTEVDVT
CEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCEEEEE
IQAARSGWTDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDVLILLDVYSAGEKPIAGADG
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCC
RSLSRTIRGRGKIDPIFVADINALPSALANVIQGGDLVLTQGAGDVGRVAKQLESLQLDI
CHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHH
NKMQNA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA