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The map label for this gene is parC [H]

Identifier: 218708461

GI number: 218708461

Start: 434072

End: 436330

Strand: Direct

Name: parC [H]

Synonym: VS_0424

Alternate gene names: 218708461

Gene position: 434072-436330 (Clockwise)

Preceding gene: 218708460

Following gene: 218708465

Centisome position: 13.16

GC content: 46.61

Gene sequence:

>2259_bases
ATGTCTAACGAAATTACATATGATGGCGTTGAACAGCTGCCAATGCGCAAGTTCACCGAAGATGCCTACTTAAATTACTC
AATGTACGTGATCATGGATCGTGCATTACCGTATATCGGTGATGGCTTGAAGCCAGTACAGCGTCGTATTATCTACGCGA
TGTCTGAGCTGGGCTTATCAGCTGCATCGAAATACAAAAAATCAGCACGTACCGTTGGTGACGTATTAGGTAAGTATCAC
CCACACGGTGACTCTGCTTGTTACGAAGCGATGGTATTGATGGCGCAGCCTTTCTCTTACCGCTACCCATTGGTAGACGG
TCAAGGTAACTGGGGTGCTCCGGACGACCCGAAATCGTTCGCTGCAATGCGTTATACCGAAGCGAAATTGTCTAAGTTTG
CTGAGGTTCTGCTAGGTGAACTAGGTCAAGGCACCGTTGATTGGCAACCAAACTTTGATGGCACCATGAAAGAGCCTCAA
ATGTTGCCAGCACGTCTGCCTCACATCTTACTTAACGGTATTACTGGTATCGCGGTAGGTATGGCGACTGACATCCCGCC
TCACAATGTCCGTGAAGTGGCGAACGCAGCGATTCACTTGATTGATACGCCGAAAGCTGAACTTCCAGATGTGATGGGTT
TCATTCAAGGCCCTGATTACCCGACAGAGGCTGAGATTATTTCGCCGAAGTCGGACATCGAAAAGATCTACCGTACTGGA
CGTGGCAGCATCAAGATGCGCGCGGTTTGGCACAAGGAAGGCTCTGATATTGTTATCACTGCTTTACCTCATCAAGTGTC
AGGTGCGAAGTTACTTGAGCAAATTGCTAACCAGATGCGCGCTAAGAAGCTGCCAATGGTTGACGACTTGCGTGATGAAT
CGGATCACGAGAACCCAACGCGCATCGTTGTCGTTCCTCGTTCAAACCGTATCGACTGTGACCAATTGATGAGTCACCTA
TTCGCTTCGACGGATCTAGAGAAAAACTTCCGCGTTAACTTGAACATGATTGGTTTAGACAATCGTCCTCAAGTTAAAGG
CCTAGTTCAAATTCTGAAAGAGTGGATTGAGTTCCGTCGCACGACCGTTCGCCGTCGTTTACAGTACCGTTTAGATAAAG
TACTAGCACGTTTGCACATTTTAGAAGGTTTGCTTGCTGCCTATCTTAATATCGATGAAGTGATTGAAATCATTCGTACA
GAAGACGAACCATGCCCTGTATTGATGAGCCGTTTCAACATTTCTGAAATTCAAGCCAATGCGATTCTTGATATTAAACT
TCGTAACTTAGCTAAGTTAGAAGAGTTTAAAATCCGAGCGGAACAAGAAGAGCTTGAAGCTGAACGCGAAAAGCTTGAAA
AGCTACTCGGTTCAGAGCGTCGCTTGAATACGTTGATCAAGAAAGAAATCCAAGCAGATGCAGATAAATACGGCGATGAT
CGTCGTTCACCTCTGATTGAGCGTGCTGAAGCGAAAGCGCTAACAGAACGCGACTTAGTACCAAGCGAACCAATCACGGT
TGTGTTGTCTGAGAAAGGTTGGATTCGTCATGCTAAAGGGCATGAAGTTGATGCTGAAGGCTTGAACTACAAATCTGGTG
ATAAGTTCTTAGCGAGTGCTAAGGGTAAGAGTAACCAACAAGCGGTGTTCCTCGGCAGTGATGGCCGAAGCTACTCCCTT
GAATCTCATTCATTACCGTCGGCACGTAGTCAAGGTGAGCCAATTACAGGCCGCTTGAATGTCAGCCCAGGTACTTCGAT
TCGCCAAGTGGTGATGGGAGAGAATGAACAATTATGGTTAGTCGGTTCTGATGCAGGTTATGGCTTTGTTTGTAAGGGTA
GCGATCTGCTGTCAAAGAACAAGAGCGGTAAAGCGTTAGTTAACTTGCCACAAGCTTCTGAAGTGATGTTGCCAAGCCCT
ATTGCAGATCTGGACAGTAACCAGATTCTGGCGATTACTAACCAAGGCCGTATGTTGTTGTTCCCTATTAAAGACCTACC
TCAGCTGAGCAAAGGTAAAGGCAATAAGATCATCAACATCCCTTCTGCGAAAGCAAAAGAGCGAGAAGAGTTTGTATCGC
ATCTGATGGCTATTCCAGAGAATGCAACGCTGACTATTTACGCGGGCAAACGTAAACTTGGCTTGAAACCTGCGGATCTT
GAAAACTTCCGTGGTGAGCGTGGTCGTCGTGGTGGTCTGCTCCCAAGAGGTTTGCAGCGTGTGACTCGTATCGATATCGA
TGAACCTAGTGACGCTTAG

Upstream 100 bases:

>100_bases
AGCGACCAACGAGATGATGGACATGCTGCTTGGTAAAAAACGTGCAGATGATCGCCGTACATGGCTACAGACTAACGGTG
ATATGGCCGAGGTATAATGG

Downstream 100 bases:

>100_bases
TTTTGATTGAGTTTATCATTAGCTTTGATTGATAAAAGAAAACCCAGCTTAAGAGCTGGGTTTTTTGTATCTATACTTTT
TGTCTCTGTAATTGGCGGTT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MSNEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSAASKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEVLLGELGQGTVDWQPNFDGTMKEPQ
MLPARLPHILLNGITGIAVGMATDIPPHNVREVANAAIHLIDTPKAELPDVMGFIQGPDYPTEAEIISPKSDIEKIYRTG
RGSIKMRAVWHKEGSDIVITALPHQVSGAKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVVVPRSNRIDCDQLMSHL
FASTDLEKNFRVNLNMIGLDNRPQVKGLVQILKEWIEFRRTTVRRRLQYRLDKVLARLHILEGLLAAYLNIDEVIEIIRT
EDEPCPVLMSRFNISEIQANAILDIKLRNLAKLEEFKIRAEQEELEAEREKLEKLLGSERRLNTLIKKEIQADADKYGDD
RRSPLIERAEAKALTERDLVPSEPITVVLSEKGWIRHAKGHEVDAEGLNYKSGDKFLASAKGKSNQQAVFLGSDGRSYSL
ESHSLPSARSQGEPITGRLNVSPGTSIRQVVMGENEQLWLVGSDAGYGFVCKGSDLLSKNKSGKALVNLPQASEVMLPSP
IADLDSNQILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPSAKAKEREEFVSHLMAIPENATLTIYAGKRKLGLKPADL
ENFRGERGRRGGLLPRGLQRVTRIDIDEPSDA

Sequences:

>Translated_752_residues
MSNEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSAASKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEVLLGELGQGTVDWQPNFDGTMKEPQ
MLPARLPHILLNGITGIAVGMATDIPPHNVREVANAAIHLIDTPKAELPDVMGFIQGPDYPTEAEIISPKSDIEKIYRTG
RGSIKMRAVWHKEGSDIVITALPHQVSGAKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVVVPRSNRIDCDQLMSHL
FASTDLEKNFRVNLNMIGLDNRPQVKGLVQILKEWIEFRRTTVRRRLQYRLDKVLARLHILEGLLAAYLNIDEVIEIIRT
EDEPCPVLMSRFNISEIQANAILDIKLRNLAKLEEFKIRAEQEELEAEREKLEKLLGSERRLNTLIKKEIQADADKYGDD
RRSPLIERAEAKALTERDLVPSEPITVVLSEKGWIRHAKGHEVDAEGLNYKSGDKFLASAKGKSNQQAVFLGSDGRSYSL
ESHSLPSARSQGEPITGRLNVSPGTSIRQVVMGENEQLWLVGSDAGYGFVCKGSDLLSKNKSGKALVNLPQASEVMLPSP
IADLDSNQILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPSAKAKEREEFVSHLMAIPENATLTIYAGKRKLGLKPADL
ENFRGERGRRGGLLPRGLQRVTRIDIDEPSDA
>Mature_751_residues
SNEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSAASKYKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEVLLGELGQGTVDWQPNFDGTMKEPQM
LPARLPHILLNGITGIAVGMATDIPPHNVREVANAAIHLIDTPKAELPDVMGFIQGPDYPTEAEIISPKSDIEKIYRTGR
GSIKMRAVWHKEGSDIVITALPHQVSGAKLLEQIANQMRAKKLPMVDDLRDESDHENPTRIVVVPRSNRIDCDQLMSHLF
ASTDLEKNFRVNLNMIGLDNRPQVKGLVQILKEWIEFRRTTVRRRLQYRLDKVLARLHILEGLLAAYLNIDEVIEIIRTE
DEPCPVLMSRFNISEIQANAILDIKLRNLAKLEEFKIRAEQEELEAEREKLEKLLGSERRLNTLIKKEIQADADKYGDDR
RSPLIERAEAKALTERDLVPSEPITVVLSEKGWIRHAKGHEVDAEGLNYKSGDKFLASAKGKSNQQAVFLGSDGRSYSLE
SHSLPSARSQGEPITGRLNVSPGTSIRQVVMGENEQLWLVGSDAGYGFVCKGSDLLSKNKSGKALVNLPQASEVMLPSPI
ADLDSNQILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPSAKAKEREEFVSHLMAIPENATLTIYAGKRKLGLKPADLE
NFRGERGRRGGLLPRGLQRVTRIDIDEPSDA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=745, Percent_Identity=69.2617449664429, Blast_Score=1100, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=704, Percent_Identity=35.9375, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=406, Percent_Identity=25.3694581280788, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=201, Percent_Identity=27.363184079602, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83983; Mature: 83851

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEEHHCHHHCCCHHHHHHHHHHHHHHHCHH
AASKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTEAKLSKFAEVLLGELGQGTVDWQPNFDGTMKEPQMLPARLPHILLNGITGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHH
MATDIPPHNVREVANAAIHLIDTPKAELPDVMGFIQGPDYPTEAEIISPKSDIEKIYRTG
HCCCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
RGSIKMRAVWHKEGSDIVITALPHQVSGAKLLEQIANQMRAKKLPMVDDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
RIVVVPRSNRIDCDQLMSHLFASTDLEKNFRVNLNMIGLDNRPQVKGLVQILKEWIEFRR
EEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
TTVRRRLQYRLDKVLARLHILEGLLAAYLNIDEVIEIIRTEDEPCPVLMSRFNISEIQAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCHHHHCCC
AILDIKLRNLAKLEEFKIRAEQEELEAEREKLEKLLGSERRLNTLIKKEIQADADKYGDD
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLIERAEAKALTERDLVPSEPITVVLSEKGWIRHAKGHEVDAEGLNYKSGDKFLASA
CCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCEEEC
KGKSNQQAVFLGSDGRSYSLESHSLPSARSQGEPITGRLNVSPGTSIRQVVMGENEQLWL
CCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCEEEE
VGSDAGYGFVCKGSDLLSKNKSGKALVNLPQASEVMLPSPIADLDSNQILAITNQGRMLL
EECCCCCEEEECCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEE
FPIKDLPQLSKGKGNKIINIPSAKAKEREEFVSHLMAIPENATLTIYAGKRKLGLKPADL
EECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCH
ENFRGERGRRGGLLPRGLQRVTRIDIDEPSDA
HHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEEHHCHHHCCCHHHHHHHHHHHHHHHCHH
AASKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTEAKLSKFAEVLLGELGQGTVDWQPNFDGTMKEPQMLPARLPHILLNGITGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHH
MATDIPPHNVREVANAAIHLIDTPKAELPDVMGFIQGPDYPTEAEIISPKSDIEKIYRTG
HCCCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
RGSIKMRAVWHKEGSDIVITALPHQVSGAKLLEQIANQMRAKKLPMVDDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
RIVVVPRSNRIDCDQLMSHLFASTDLEKNFRVNLNMIGLDNRPQVKGLVQILKEWIEFRR
EEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
TTVRRRLQYRLDKVLARLHILEGLLAAYLNIDEVIEIIRTEDEPCPVLMSRFNISEIQAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCHHHHCCC
AILDIKLRNLAKLEEFKIRAEQEELEAEREKLEKLLGSERRLNTLIKKEIQADADKYGDD
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLIERAEAKALTERDLVPSEPITVVLSEKGWIRHAKGHEVDAEGLNYKSGDKFLASA
CCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCEEEC
KGKSNQQAVFLGSDGRSYSLESHSLPSARSQGEPITGRLNVSPGTSIRQVVMGENEQLWL
CCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCEEEE
VGSDAGYGFVCKGSDLLSKNKSGKALVNLPQASEVMLPSPIADLDSNQILAITNQGRMLL
EECCCCCEEEECCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEE
FPIKDLPQLSKGKGNKIINIPSAKAKEREEFVSHLMAIPENATLTIYAGKRKLGLKPADL
EECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCH
ENFRGERGRRGGLLPRGLQRVTRIDIDEPSDA
HHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]