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The map label for this gene is folB [H]

Identifier: 218708441

GI number: 218708441

Start: 410368

End: 410727

Strand: Direct

Name: folB [H]

Synonym: VS_0404

Alternate gene names: 218708441

Gene position: 410368-410727 (Clockwise)

Preceding gene: 218708439

Following gene: 218708442

Centisome position: 12.44

GC content: 45.0

Gene sequence:

>360_bases
ATGGCACTGGATAAAGTTTTCATTGAACAGCTAGAAGTAATTACAACGATCGGTGTTTACGATTGGGAACAAGAGATTAA
ACAAAAACTTGTGCTTGATATTGAAATGGCTCATGACAATCGCCCAGCAGGTAAGAGTGATGATGTTGTCGATGCTTTGG
ATTACTCGACAGTCAGCACTGCCGTACTTGACCACATTGCGAATGGCCGATTCCTATTGGTTGAGCGTGTGGCAGAAGAA
GTCGCTGAATTGATTATGACTCAGTTCTCAGTGCCTTGGATTAAAATCCGTTTAGCGAAGCCTGGCGCAGTACCACAAGC
AAAAGCCGTGGGTGTGATCATCGAACGAGGCCAAGCATGA

Upstream 100 bases:

>100_bases
ATAATGCTCAATCTAAGAGTAATTGATATCATATCTGGAATTACGCAAATAATACGTTTTTTTCCCCGGTATGGGTATCC
GACCTCTAAAAGGACAAGTC

Downstream 100 bases:

>100_bases
CAATAGCCTATGTTGGTGTTGGCACGAACATAGACCGCGACAAGCATGCAAGGGTGGCATGGACAGAGCTTCAATCATTA
GGGACTAACCTTAAATGCTC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MALDKVFIEQLEVITTIGVYDWEQEIKQKLVLDIEMAHDNRPAGKSDDVVDALDYSTVSTAVLDHIANGRFLLVERVAEE
VAELIMTQFSVPWIKIRLAKPGAVPQAKAVGVIIERGQA

Sequences:

>Translated_119_residues
MALDKVFIEQLEVITTIGVYDWEQEIKQKLVLDIEMAHDNRPAGKSDDVVDALDYSTVSTAVLDHIANGRFLLVERVAEE
VAELIMTQFSVPWIKIRLAKPGAVPQAKAVGVIIERGQA
>Mature_118_residues
ALDKVFIEQLEVITTIGVYDWEQEIKQKLVLDIEMAHDNRPAGKSDDVVDALDYSTVSTAVLDHIANGRFLLVERVAEEV
AELIMTQFSVPWIKIRLAKPGAVPQAKAVGVIIERGQA

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=116, Percent_Identity=65.5172413793103, Blast_Score=162, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13200; Mature: 13069

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDKVFIEQLEVITTIGVYDWEQEIKQKLVLDIEMAHDNRPAGKSDDVVDALDYSTVST
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHCHHHHHH
AVLDHIANGRFLLVERVAEEVAELIMTQFSVPWIKIRLAKPGAVPQAKAVGVIIERGQA
HHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHEEEEECCCC
>Mature Secondary Structure 
ALDKVFIEQLEVITTIGVYDWEQEIKQKLVLDIEMAHDNRPAGKSDDVVDALDYSTVST
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHCHHHHHH
AVLDHIANGRFLLVERVAEEVAELIMTQFSVPWIKIRLAKPGAVPQAKAVGVIIERGQA
HHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]