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The map label for this gene is pgi

Identifier: 218708341

GI number: 218708341

Start: 282394

End: 284046

Strand: Direct

Name: pgi

Synonym: VS_0288

Alternate gene names: 218708341

Gene position: 282394-284046 (Clockwise)

Preceding gene: 218708339

Following gene: 218708344

Centisome position: 8.56

GC content: 45.37

Gene sequence:

>1653_bases
ATGTTGAAAAATATCAACCCAACGCAAACACAAGCGTGGAAAGCTCTAACTGCACATTTTGAGTCTGCTCAAGATATGGA
TATGAAAGAGCTATTTGCTCAAGATGCAAAGCGTTTCGAGAGCTTTTCTACTCGTTTCGGTTCAGACATCTTAGTGGATT
ACTCTAAGAACCTTATCGACGCTGAAACAATGCAGCACCTATTTGCTCTTGCGAACGAGACTGAAGTTAAGTCTGCAATC
GAAGCAATGTTCGGCGGTGATGCAATCAACAAGACTGAAGGTCGTTCAGTTCTTCACACTGCGTTACGTAACCGTAGCGA
CAAGCCAGTAATGGTTGATGGCAAAGACGTAATGCCAGCTGTGAATGCAGTACTAGCAAAAATGGAACTGTTCACACACC
GTATCGTTTCTGGTGAGTGGAAAGGTTACACAGGTAAAGAGATCACTGATGTAGTTAACATCGGTATCGGCGGTTCAGAC
CTTGGTCCATACATGGTAACTGAAGCACTTACGCCATACAAAACTCGCCTAAACATGCACTTTGTTTCTAACGTAGACGG
CACTCACATCGTTGAGACACTAAAGCCTCTTAACCCAGAAACAACACTGTTCCTAGTGGCATCTAAGACATTTACCACTC
AAGAAACAATGACGAACGCACACTCTGCGCGTGATTGGTTCTTGGCTGAAGCGGGCGACTCAGCACACGTTGCTAAGCAC
TTCGCAGCACTATCAACAAACGCGGCTTCAGTTGCTGAGTTTGGTATTGATACTGACAACATGTTCGAATTCTGGGATTG
GGTAGGCGGTCGTTACTCACTATGGTCAGCGATCGGTCTTTCTATCTCACTATCTATTGGCTTCGATAACTTCGCTGAGC
TACTCGATGGCGCACACGAGATGGATAACCACTTTGCTTCAACGGAATTTGAAAGCAACATTCCAGTGATCCTTGCGTTA
ATTGGTGTTTGGTACAACAACTTCCACGGCGCTGAGTCAGAAGCAATCCTACCTTACGATCAATACATGCACCGTTTTGC
TGCTTACTTCCAGCAAGGTAACATGGAATCTAACGGTAAATTCGTTGACCGTGAAGGTAACCCAGTAGAATACCAAACAG
GCCCTATCATCTGGGGTGAACCTGGTACAAACGGTCAGCACGCGTTCTACCAACTGATTCACCAAGGCACTAAGCTGATC
CCATCAGACTTCATTGCTCCGGCTATCAGCCACAACCCAGCATCTGATCACCACCAGAAGCTAATGTCTAACTTCTTTGC
TCAAACTGAAGCGCTAGCTTTCGGTAAGACAAAAGAGACAGTAGAAGCTGAATTCCTAGCGGCTGGCAAAACAGCTGAAG
AAGTTGCTGAGCTAGTACCTTTCAAAGTATTTGAAGGTAACCGCCCAACGAACTCTATTCTTGTTAAGCAAATCAACCCT
CGCTCTTTAGGTAACCTAATCGCGATGTACGAGCACAAGATCTTCGTTCAAGGCGTTATCTGGAATATCTTCAGCTTCGA
CCAATGGGGCGTAGAACTTGGTAAGCAACTAGCAAACCAAATTCTTCCAGAGCTTGCAGACGATGCACAAGTAACGTCTC
ACGACAGCTCTACTAACGGTCTAATCAACGCATTTAAAGCGCTGAAAGCTTAA

Upstream 100 bases:

>100_bases
GTCATCATAGAAAAATATAAACTTTCGCCTAATCGGGGGTTCTATTCATCACTTTGGTGACGTCTAGAATAAAACCTACA
GTAACATCGGGATAGATACC

Downstream 100 bases:

>100_bases
GACTGTTTAAGTCACACCAAGTCATAACTGTAAACGCCAACCTTTCGGTTGGCGTTTTTTATGTCCGTTGATTTTACGGC
AATAAAAAAGGCTGACGTAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLKNINPTQTQAWKALTAHFESAQDMDMKELFAQDAKRFESFSTRFGSDILVDYSKNLIDAETMQHLFALANETEVKSAI
EAMFGGDAINKTEGRSVLHTALRNRSDKPVMVDGKDVMPAVNAVLAKMELFTHRIVSGEWKGYTGKEITDVVNIGIGGSD
LGPYMVTEALTPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLAEAGDSAHVAKH
FAALSTNAASVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSISLSIGFDNFAELLDGAHEMDNHFASTEFESNIPVILAL
IGVWYNNFHGAESEAILPYDQYMHRFAAYFQQGNMESNGKFVDREGNPVEYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PSDFIAPAISHNPASDHHQKLMSNFFAQTEALAFGKTKETVEAEFLAAGKTAEEVAELVPFKVFEGNRPTNSILVKQINP
RSLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDAQVTSHDSSTNGLINAFKALKA

Sequences:

>Translated_550_residues
MLKNINPTQTQAWKALTAHFESAQDMDMKELFAQDAKRFESFSTRFGSDILVDYSKNLIDAETMQHLFALANETEVKSAI
EAMFGGDAINKTEGRSVLHTALRNRSDKPVMVDGKDVMPAVNAVLAKMELFTHRIVSGEWKGYTGKEITDVVNIGIGGSD
LGPYMVTEALTPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLAEAGDSAHVAKH
FAALSTNAASVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSISLSIGFDNFAELLDGAHEMDNHFASTEFESNIPVILAL
IGVWYNNFHGAESEAILPYDQYMHRFAAYFQQGNMESNGKFVDREGNPVEYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PSDFIAPAISHNPASDHHQKLMSNFFAQTEALAFGKTKETVEAEFLAAGKTAEEVAELVPFKVFEGNRPTNSILVKQINP
RSLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDAQVTSHDSSTNGLINAFKALKA
>Mature_550_residues
MLKNINPTQTQAWKALTAHFESAQDMDMKELFAQDAKRFESFSTRFGSDILVDYSKNLIDAETMQHLFALANETEVKSAI
EAMFGGDAINKTEGRSVLHTALRNRSDKPVMVDGKDVMPAVNAVLAKMELFTHRIVSGEWKGYTGKEITDVVNIGIGGSD
LGPYMVTEALTPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLAEAGDSAHVAKH
FAALSTNAASVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSISLSIGFDNFAELLDGAHEMDNHFASTEFESNIPVILAL
IGVWYNNFHGAESEAILPYDQYMHRFAAYFQQGNMESNGKFVDREGNPVEYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PSDFIAPAISHNPASDHHQKLMSNFFAQTEALAFGKTKETVEAEFLAAGKTAEEVAELVPFKVFEGNRPTNSILVKQINP
RSLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDAQVTSHDSSTNGLINAFKALKA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=532, Percent_Identity=62.9699248120301, Blast_Score=708, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=532, Percent_Identity=58.6466165413534, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=74.8633879781421, Blast_Score=877, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=62.7272727272727, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=63.1192660550459, Blast_Score=710, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=58.5009140767825, Blast_Score=639, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=546, Percent_Identity=64.4688644688645, Blast_Score=722, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=546, Percent_Identity=64.4688644688645, Blast_Score=722, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=546, Percent_Identity=64.4688644688645, Blast_Score=722, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_VIBSL (B7VI73)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002415962.1
- ProteinModelPortal:   B7VI73
- SMR:   B7VI73
- GeneID:   7159939
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0288
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 60970; Mature: 60970

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 387-387 ACT_SITE 515-515

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNINPTQTQAWKALTAHFESAQDMDMKELFAQDAKRFESFSTRFGSDILVDYSKNLID
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
AETMQHLFALANETEVKSAIEAMFGGDAINKTEGRSVLHTALRNRSDKPVMVDGKDVMPA
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHH
VNAVLAKMELFTHRIVSGEWKGYTGKEITDVVNIGIGGSDLGPYMVTEALTPYKTRLNMH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHEEEE
FVSNVDGTHIVETLKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLAEAGDSAHVAKH
EECCCCCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCHHHHHH
FAALSTNAASVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSISLSIGFDNFAELLDGAHE
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCEEEEEECHHHHHHHHHHHHH
MDNHFASTEFESNIPVILALIGVWYNNFHGAESEAILPYDQYMHRFAAYFQQGNMESNGK
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
FVDREGNPVEYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPSDFIAPAISHNPASDHHQK
EECCCCCCEEEECCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHH
LMSNFFAQTEALAFGKTKETVEAEFLAAGKTAEEVAELVPFKVFEGNRPTNSILVKQINP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCEEEEECCC
RSLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDAQVTSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHH
LINAFKALKA
HHHHHHHHCC
>Mature Secondary Structure
MLKNINPTQTQAWKALTAHFESAQDMDMKELFAQDAKRFESFSTRFGSDILVDYSKNLID
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
AETMQHLFALANETEVKSAIEAMFGGDAINKTEGRSVLHTALRNRSDKPVMVDGKDVMPA
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHH
VNAVLAKMELFTHRIVSGEWKGYTGKEITDVVNIGIGGSDLGPYMVTEALTPYKTRLNMH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHEEEE
FVSNVDGTHIVETLKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLAEAGDSAHVAKH
EECCCCCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCHHHHHH
FAALSTNAASVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSISLSIGFDNFAELLDGAHE
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCEEEEEECHHHHHHHHHHHHH
MDNHFASTEFESNIPVILALIGVWYNNFHGAESEAILPYDQYMHRFAAYFQQGNMESNGK
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
FVDREGNPVEYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPSDFIAPAISHNPASDHHQK
EECCCCCCEEEECCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHH
LMSNFFAQTEALAFGKTKETVEAEFLAAGKTAEEVAELVPFKVFEGNRPTNSILVKQINP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCEEEEECCC
RSLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDAQVTSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHH
LINAFKALKA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA