Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 218708224

GI number: 218708224

Start: 156242

End: 156865

Strand: Reverse

Name: gmk [H]

Synonym: VS_0161

Alternate gene names: 218708224

Gene position: 156865-156242 (Counterclockwise)

Preceding gene: 218708227

Following gene: 218708223

Centisome position: 4.75

GC content: 45.19

Gene sequence:

>624_bases
ATGGGCAAAGGTACTCTTTACATCGTATCTGCACCTAGTGGCGCAGGTAAGTCGAGCTTGATCTCAGCAATGCTAGAAAC
CAATCCAACCTACGCAATGAAGGTATCTGTTTCACACACCACTCGCGGTATGCGCCCTGGTGAAGAAAATGGTGTTCACT
ACCACTTCGTAGAGAAGCATCATTTTGAAGACCTTATTAATAAAGGTGAATTCCTAGAGTACGCTGAAGTTTTCGGCAAC
TACTACGGTACTTCACGCGTTTGGATTGAAGAAAACCTAGACCGCGGTATCGATGTATTCCTAGATATCGACTGGCAAGG
TGCTCGTCAGATCCGTGAACAAATGCCTCAAGCGAAGAGTGTATTCATTCTTCCACCATCAAATGGTGAGCTAGAGCGTC
GTTTGAATGTTCGCGGCCAAGACAGCGACGAAGTTATTGCGAAACGCATGAGCGAAGCAAAATCAGAAATTTCTCACTAT
GCAGAATACGATTATGTGATCGTGAATGATGACTTTGATGCAGCCCTAATGGACTTCAGAGCTATCATTCGTGCGGAGCG
CTTAAAAGAAGATAAGCAAGCAGCGAAATACAGCGGCATGCTTACAGCACTACTAGCGGAATAA

Upstream 100 bases:

>100_bases
TTTAGATGCAACCATCGGAACAAAAATTAGAGTCAGTGCTATCTTTTATAGTGTCGGTTTATCGCCCTCACTCAATCCAA
CCAACAGTGGAAATATACAG

Downstream 100 bases:

>100_bases
TCTCTGATACCAATCGTAGTAAACAACTGGTCATTCTAGCTTGTGAAAAAGCCTGATAACGTCGTTAGAATTTTTGATTG
TAGGGTCACTACTTGTCGAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MGKGTLYIVSAPSGAGKSSLISAMLETNPTYAMKVSVSHTTRGMRPGEENGVHYHFVEKHHFEDLINKGEFLEYAEVFGN
YYGTSRVWIEENLDRGIDVFLDIDWQGARQIREQMPQAKSVFILPPSNGELERRLNVRGQDSDEVIAKRMSEAKSEISHY
AEYDYVIVNDDFDAALMDFRAIIRAERLKEDKQAAKYSGMLTALLAE

Sequences:

>Translated_207_residues
MGKGTLYIVSAPSGAGKSSLISAMLETNPTYAMKVSVSHTTRGMRPGEENGVHYHFVEKHHFEDLINKGEFLEYAEVFGN
YYGTSRVWIEENLDRGIDVFLDIDWQGARQIREQMPQAKSVFILPPSNGELERRLNVRGQDSDEVIAKRMSEAKSEISHY
AEYDYVIVNDDFDAALMDFRAIIRAERLKEDKQAAKYSGMLTALLAE
>Mature_206_residues
GKGTLYIVSAPSGAGKSSLISAMLETNPTYAMKVSVSHTTRGMRPGEENGVHYHFVEKHHFEDLINKGEFLEYAEVFGNY
YGTSRVWIEENLDRGIDVFLDIDWQGARQIREQMPQAKSVFILPPSNGELERRLNVRGQDSDEVIAKRMSEAKSEISHYA
EYDYVIVNDDFDAALMDFRAIIRAERLKEDKQAAKYSGMLTALLAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=195, Percent_Identity=36.9230769230769, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4504221, Length=195, Percent_Identity=36.9230769230769, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI226874831, Length=195, Percent_Identity=36.9230769230769, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI14780902, Length=201, Percent_Identity=30.8457711442786, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=32.5, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI38570142, Length=181, Percent_Identity=29.8342541436464, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118259, Length=178, Percent_Identity=29.2134831460674, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4505237, Length=178, Percent_Identity=29.2134831460674, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI262118255, Length=178, Percent_Identity=29.2134831460674, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI262118263, Length=178, Percent_Identity=29.2134831460674, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI21361598, Length=209, Percent_Identity=30.1435406698565, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21536464, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=64.7342995169082, Blast_Score=286, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI193203132, Length=190, Percent_Identity=37.8947368421053, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=190, Percent_Identity=37.8947368421053, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557440, Length=179, Percent_Identity=28.4916201117318, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=40.5405405405405, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356141, Length=191, Percent_Identity=38.2198952879581, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23462; Mature: 23330

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGTLYIVSAPSGAGKSSLISAMLETNPTYAMKVSVSHTTRGMRPGEENGVHYHFVEKH
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHHH
HFEDLINKGEFLEYAEVFGNYYGTSRVWIEENLDRGIDVFLDIDWQGARQIREQMPQAKS
HHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCCCE
VFILPPSNGELERRLNVRGQDSDEVIAKRMSEAKSEISHYAEYDYVIVNDDFDAALMDFR
EEEECCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHH
AIIRAERLKEDKQAAKYSGMLTALLAE
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKGTLYIVSAPSGAGKSSLISAMLETNPTYAMKVSVSHTTRGMRPGEENGVHYHFVEKH
CCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHHH
HFEDLINKGEFLEYAEVFGNYYGTSRVWIEENLDRGIDVFLDIDWQGARQIREQMPQAKS
HHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCCCE
VFILPPSNGELERRLNVRGQDSDEVIAKRMSEAKSEISHYAEYDYVIVNDDFDAALMDFR
EEEECCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHH
AIIRAERLKEDKQAAKYSGMLTALLAE
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]