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The map label for this gene is ubiE [H]

Identifier: 218708164

GI number: 218708164

Start: 90629

End: 91423

Strand: Direct

Name: ubiE [H]

Synonym: VS_0098

Alternate gene names: 218708164

Gene position: 90629-91423 (Clockwise)

Preceding gene: 218708163

Following gene: 218708165

Centisome position: 2.75

GC content: 46.54

Gene sequence:

>795_bases
ATGGTAGATAACAGCATTATGGACACAAGCGTGCAGACAAATTCAGCAGTAGAGTCAGAAACCACACACTTTGGTTTCGA
AACAGTCGCGAAAGACCAAAAAGTCGCGAAAGTAGCAGAGGTATTTCACTCTGTAGCCGCTAAATACGACATCATGAATG
ACTTAATGTCGGGTGGTGTTCACCGCTTGTGGAAGCGATTCACGATTGATTGCAGTGGCGTGCGCCCTGGTCAACGTATC
CTCGATCTTGGTGGTGGTACTGGTGACCTTACTGCGAAATTCTCGCGCATCGTTGGTGAAAAAGGCCACGTGGTTCTTGC
TGATATCAACAACTCAATGCTGAATGTTGGCCGCGATAAACTGCGTGATAGCGGTATTGTTGGCAATGTACATTATGTTC
AAGCAAACGCTGAAGAACTGCCTTTCCCTGACAACTACTTCGATTGCATTACCATCAGCTTCTGTCTGCGTAACGTAACC
GATAAAGACCAAGCACTGCGTTCAATGTACCGCGTACTTAAGCCGGGCGGTCGTCTGTTGGTTCTTGAGTTTTCTAAGCC
AGTGCTTGAGCCACTATCAAAGGTTTACGATGCATACTCTTTCCACCTATTGCCAAAAATGGGTGAGCTGATTGCTAACG
ATGCAGACAGCTATCGTTACCTTGCAGAATCAATCCGTATGCACCCTAACCAAGAAACCTTGGAAGGCATGATGCAAGAA
GCGGGTTTTGAAAATACTAAATACTTCAACCTAACGGGCGGCATTGTTGCGCTGCACCGTGGTTACAAGTTCTAG

Upstream 100 bases:

>100_bases
AAAATGCCTCCTTAGTAGAAAGACAACCCGCTGAGGATAAAGTAAACTAATCGGCCGCAGCGCCTCTAAAGAGAGAGTGT
ACTGTCGATGAGAACTTACC

Downstream 100 bases:

>100_bases
TCGAACTTGGTAGCAGGCTCGTTGAGTGTGCTAAAAAATAAGAATAAAGATACAACGGATAGGTTAACGCTTATCCGTTT
TCAAAGGTAAGGACAGTCAT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MVDNSIMDTSVQTNSAVESETTHFGFETVAKDQKVAKVAEVFHSVAAKYDIMNDLMSGGVHRLWKRFTIDCSGVRPGQRI
LDLGGGTGDLTAKFSRIVGEKGHVVLADINNSMLNVGRDKLRDSGIVGNVHYVQANAEELPFPDNYFDCITISFCLRNVT
DKDQALRSMYRVLKPGGRLLVLEFSKPVLEPLSKVYDAYSFHLLPKMGELIANDADSYRYLAESIRMHPNQETLEGMMQE
AGFENTKYFNLTGGIVALHRGYKF

Sequences:

>Translated_264_residues
MVDNSIMDTSVQTNSAVESETTHFGFETVAKDQKVAKVAEVFHSVAAKYDIMNDLMSGGVHRLWKRFTIDCSGVRPGQRI
LDLGGGTGDLTAKFSRIVGEKGHVVLADINNSMLNVGRDKLRDSGIVGNVHYVQANAEELPFPDNYFDCITISFCLRNVT
DKDQALRSMYRVLKPGGRLLVLEFSKPVLEPLSKVYDAYSFHLLPKMGELIANDADSYRYLAESIRMHPNQETLEGMMQE
AGFENTKYFNLTGGIVALHRGYKF
>Mature_264_residues
MVDNSIMDTSVQTNSAVESETTHFGFETVAKDQKVAKVAEVFHSVAAKYDIMNDLMSGGVHRLWKRFTIDCSGVRPGQRI
LDLGGGTGDLTAKFSRIVGEKGHVVLADINNSMLNVGRDKLRDSGIVGNVHYVQANAEELPFPDNYFDCITISFCLRNVT
DKDQALRSMYRVLKPGGRLLVLEFSKPVLEPLSKVYDAYSFHLLPKMGELIANDADSYRYLAESIRMHPNQETLEGMMQE
AGFENTKYFNLTGGIVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=44.2028985507246, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI48994983, Length=245, Percent_Identity=80, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17557039, Length=246, Percent_Identity=44.3089430894309, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=261, Percent_Identity=40.9961685823755, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24641702, Length=260, Percent_Identity=44.2307692307692, Blast_Score=236, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29469; Mature: 29469

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDNSIMDTSVQTNSAVESETTHFGFETVAKDQKVAKVAEVFHSVAAKYDIMNDLMSGGV
CCCCCCCCCCCCCCCCHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
HRLWKRFTIDCSGVRPGQRILDLGGGTGDLTAKFSRIVGEKGHVVLADINNSMLNVGRDK
HHHHHHHCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHH
LRDSGIVGNVHYVQANAEELPFPDNYFDCITISFCLRNVTDKDQALRSMYRVLKPGGRLL
HHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEE
VLEFSKPVLEPLSKVYDAYSFHLLPKMGELIANDADSYRYLAESIRMHPNQETLEGMMQE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHH
AGFENTKYFNLTGGIVALHRGYKF
CCCCCCEEEEECCCEEEECCCCCC
>Mature Secondary Structure
MVDNSIMDTSVQTNSAVESETTHFGFETVAKDQKVAKVAEVFHSVAAKYDIMNDLMSGGV
CCCCCCCCCCCCCCCCHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
HRLWKRFTIDCSGVRPGQRILDLGGGTGDLTAKFSRIVGEKGHVVLADINNSMLNVGRDK
HHHHHHHCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHH
LRDSGIVGNVHYVQANAEELPFPDNYFDCITISFCLRNVTDKDQALRSMYRVLKPGGRLL
HHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEE
VLEFSKPVLEPLSKVYDAYSFHLLPKMGELIANDADSYRYLAESIRMHPNQETLEGMMQE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHH
AGFENTKYFNLTGGIVALHRGYKF
CCCCCCEEEEECCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA