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The map label for this gene is ilvY [H]

Identifier: 218708132

GI number: 218708132

Start: 50004

End: 50960

Strand: Reverse

Name: ilvY [H]

Synonym: VS_0060

Alternate gene names: 218708132

Gene position: 50960-50004 (Counterclockwise)

Preceding gene: 218708134

Following gene: 218708128

Centisome position: 1.54

GC content: 42.63

Gene sequence:

>957_bases
TTGCTGAAAGTGATATATTCACAATTAGTTATTGCAATAAATGCAACATGGAAACGATCGCAAAACATGAACATAAAATC
TCTACAATTATTTATACATTTATGTGATAGCAAGAGTTTCAGCAAAACAGCTGCGGCTATGCACGTCAGTCCTTCAGCAC
TTAGTCGTCAGGTACAAAAGCTTGAAGAAGAAACGGGGCAAGAATTGCTTATCAGAGATAACCGCAGTGTTGATCTCACT
CCAGCAGGAAAGCACCTATTGCCAGTAGCATTAAGCATCGTTGGAGAGTGGCAGCAATACAATCTTCACCTGAAAGGTGG
TGAGCAAGAACTTAAAGGTGAAATCCGCATATTTTGCTCGGTAACGGCTAGTTACAGCCACCTACCTGAGCTCATAACCG
AATTCAGAGCTATTCATCCGTACATTGAATTTAAGCTCTCTACAGGCGATCCGGCTCAATCCATCGACAAGATTTTAAAT
GATGAAGCAGATATTGCTATCTCAGCGAAGCCAGACATTCTTCCTTCAAGATTAGAGTTCGAAACCATCAGCGATATACC
ACTGTCAGTCATCATCCCATCCGGTGTGAGTAGTTTTAGCCAGCAGCTGCAATCAGAGAAACCAAACTGGAATGAAGTAC
CTTTTATCATCCCAGAAGCAGGTACTGCACGAGAACGTGCGAACGCATGGTTCAAAAAGATGAAGATAAAACCCAATATT
TACGCTCAGGTATCTGGTCATGAAGCGATCGTCAGTATGGTTGCCCTTGGTTGTGGGGTTGGTATTGCGCCAGACGTTGT
AATCAACAACAGTCCTGTGAGAGATAAAGTCGACCGCTTAAAAATAGAACCTATCAAACCCTTTGAATTAGGTGTCTGCT
GTAAACGATCTCAACTTGAGAACCCACTGATTAGAGCGTTTTGGCAAGTAGCCGAAGGAAAATATCTCCCTGACTAG

Upstream 100 bases:

>100_bases
GTATTGAAATAGTTAGCCATTGTAGGGCACTCCTTTAAAAATAAGTCCGTAAGGTCGATATCTCTCTATCGAATGACTTC
ATACTAAAACAGACACTCCG

Downstream 100 bases:

>100_bases
TTAACTTTAGATATGCTGGTTAAGAGAATAATAGAGAGCACGTTAGTGCTCTTTTTTGTTTTTCTAAATAGCAGATATGA
AAAAGCCCGCTGATTTCTCA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MLKVIYSQLVIAINATWKRSQNMNIKSLQLFIHLCDSKSFSKTAAAMHVSPSALSRQVQKLEEETGQELLIRDNRSVDLT
PAGKHLLPVALSIVGEWQQYNLHLKGGEQELKGEIRIFCSVTASYSHLPELITEFRAIHPYIEFKLSTGDPAQSIDKILN
DEADIAISAKPDILPSRLEFETISDIPLSVIIPSGVSSFSQQLQSEKPNWNEVPFIIPEAGTARERANAWFKKMKIKPNI
YAQVSGHEAIVSMVALGCGVGIAPDVVINNSPVRDKVDRLKIEPIKPFELGVCCKRSQLENPLIRAFWQVAEGKYLPD

Sequences:

>Translated_318_residues
MLKVIYSQLVIAINATWKRSQNMNIKSLQLFIHLCDSKSFSKTAAAMHVSPSALSRQVQKLEEETGQELLIRDNRSVDLT
PAGKHLLPVALSIVGEWQQYNLHLKGGEQELKGEIRIFCSVTASYSHLPELITEFRAIHPYIEFKLSTGDPAQSIDKILN
DEADIAISAKPDILPSRLEFETISDIPLSVIIPSGVSSFSQQLQSEKPNWNEVPFIIPEAGTARERANAWFKKMKIKPNI
YAQVSGHEAIVSMVALGCGVGIAPDVVINNSPVRDKVDRLKIEPIKPFELGVCCKRSQLENPLIRAFWQVAEGKYLPD
>Mature_318_residues
MLKVIYSQLVIAINATWKRSQNMNIKSLQLFIHLCDSKSFSKTAAAMHVSPSALSRQVQKLEEETGQELLIRDNRSVDLT
PAGKHLLPVALSIVGEWQQYNLHLKGGEQELKGEIRIFCSVTASYSHLPELITEFRAIHPYIEFKLSTGDPAQSIDKILN
DEADIAISAKPDILPSRLEFETISDIPLSVIIPSGVSSFSQQLQSEKPNWNEVPFIIPEAGTARERANAWFKKMKIKPNI
YAQVSGHEAIVSMVALGCGVGIAPDVVINNSPVRDKVDRLKIEPIKPFELGVCCKRSQLENPLIRAFWQVAEGKYLPD

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=292, Percent_Identity=47.6027397260274, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1788887, Length=250, Percent_Identity=26, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787806, Length=261, Percent_Identity=22.6053639846743, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=21.3058419243986, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=25.296442687747, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788748, Length=298, Percent_Identity=25.8389261744966, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788296, Length=253, Percent_Identity=26.4822134387352, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693193, Length=144, Percent_Identity=31.9444444444444, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI157672245, Length=243, Percent_Identity=22.6337448559671, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787530, Length=264, Percent_Identity=23.1060606060606, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790399, Length=292, Percent_Identity=23.2876712328767, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789440, Length=148, Percent_Identity=29.7297297297297, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787589, Length=216, Percent_Identity=24.537037037037, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789639, Length=215, Percent_Identity=27.4418604651163, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=25, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35452; Mature: 35452

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVIYSQLVIAINATWKRSQNMNIKSLQLFIHLCDSKSFSKTAAAMHVSPSALSRQVQK
CHHHHEEHEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHEECCHHHHHHHHHH
LEEETGQELLIRDNRSVDLTPAGKHLLPVALSIVGEWQQYNLHLKGGEQELKGEIRIFCS
HHHHCCCEEEEECCCCEECCCCCCHHHHHHHHHHCCHHHEEEEECCCHHHCCCEEEEEEE
VTASYSHLPELITEFRAIHPYIEFKLSTGDPAQSIDKILNDEADIAISAKPDILPSRLEF
ECCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCC
ETISDIPLSVIIPSGVSSFSQQLQSEKPNWNEVPFIIPEAGTARERANAWFKKMKIKPNI
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCE
YAQVSGHEAIVSMVALGCGVGIAPDVVINNSPVRDKVDRLKIEPIKPFELGVCCKRSQLE
EEEECCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHEECCCCCCCHHCHHCCHHHCC
NPLIRAFWQVAEGKYLPD
CHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKVIYSQLVIAINATWKRSQNMNIKSLQLFIHLCDSKSFSKTAAAMHVSPSALSRQVQK
CHHHHEEHEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHEECCHHHHHHHHHH
LEEETGQELLIRDNRSVDLTPAGKHLLPVALSIVGEWQQYNLHLKGGEQELKGEIRIFCS
HHHHCCCEEEEECCCCEECCCCCCHHHHHHHHHHCCHHHEEEEECCCHHHCCCEEEEEEE
VTASYSHLPELITEFRAIHPYIEFKLSTGDPAQSIDKILNDEADIAISAKPDILPSRLEF
ECCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCC
ETISDIPLSVIIPSGVSSFSQQLQSEKPNWNEVPFIIPEAGTARERANAWFKKMKIKPNI
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCE
YAQVSGHEAIVSMVALGCGVGIAPDVVINNSPVRDKVDRLKIEPIKPFELGVCCKRSQLE
EEEECCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHEECCCCCCCHHCHHCCHHHCC
NPLIRAFWQVAEGKYLPD
CHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]