BacMap

Definition	Escherichia coli UMN026 chromosome, complete genome.
Accession	NC_011751
Length	5,202,090

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The map label for this gene is yciK [H]

Identifier: 218704794

GI number: 218704794

Start: 1580187

End: 1580945

Strand: Reverse

Name: yciK [H]

Synonym: ECUMN_1569

Alternate gene names: 218704794

Gene position: 1580945-1580187 (Counterclockwise)

Preceding gene: 218704796

Following gene: 218704793

Centisome position: 30.39

GC content: 52.31

Gene sequence:

>759_bases
ATGCATTACCAGCCAAAACAAGATTTACTCAATGATCGCATTATCCTGGTGACGGGAGCCAGCGATGGGATTGGTCGTGA
AGCCGCGATGACGTATGCACGCTATGGTGCGACTGTGATTCTGTTGGGCCGTAATGAAGAAAAATTACATCAGGTAGCCA
GCCACATAAACGAAGAAACTGGGCGTCAGCCACAGTGGTTTATTCTCGATTTGCTGACCTGCACGTCCGAAAATTGCCAA
CAACTGGCACAGCGCATTGCCGTTAATTATCCACGTCTGGATGGTGTTTTGCATAATGCCGGATTGCTCGGCGATGTTTG
CCCAATGAGCGAACAAAATCCGCAGGTCTGGCAGGACGTCATGCAGGTCAACGTTAATGCCACCTTTATGCTCACCCAAG
CACTGCTTCCTTTATTACTCAAATCGGACGCGGGTTCACTGGTCTTTACTTCATCAAGCGTTGGACGTCAGGGGCGTGCA
AACTGGGGCGCATATGCAGCGTCGAAATTTGCCACCGAAGGGATGATGCAGGTACTGGCCGATGAATATCAGCAGCGCCT
GCGCGTCAACTGCATTAACCCAGGCGGTACGCGCACCGCAATGCGTGCCAACGCCTTCCCGACCGAAGATCCACAGAAAC
TTAAAACACCCGCTGATATCATGCCGCTCTACCTCTGGCTGATGGGCGATGACAGCCGCCGTAAAACCGGCATGACCTTT
GACGCCCAACCGGGCCGTAAACCAGGAATTTCCCAATGA

Upstream 100 bases:

>100_bases
CGCCCCAGGCTGATTGAAATGCCCTTCTGTTTCAGGCATAAAGCCCCAAAGTCTTAAAGTACACTGGCAGCGCGACAGAC
AACGTCGTTGAGGAGTAGCC

Downstream 100 bases:

>100_bases
GTGATGAACGCTACCAACAGCGTCAGCAGCGAGTGAAAGAAAAAGTAGATGCTCGTGTGGCCCAGGCCCAGGATGAACGC
GGTATTATCATCGTCTTTAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLHQVASHINEETGRQPQWFILDLLTCTSENCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRANAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Sequences:

>Translated_252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLHQVASHINEETGRQPQWFILDLLTCTSENCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRANAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ
>Mature_252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLHQVASHINEETGRQPQWFILDLLTCTSENCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRANAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=206, Percent_Identity=31.0679611650485, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI142976729, Length=222, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4504505, Length=236, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=25, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI66933014, Length=246, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI40807363, Length=207, Percent_Identity=25.6038647342995, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI7657478, Length=222, Percent_Identity=29.2792792792793, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=27.363184079602, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190704, Length=189, Percent_Identity=24.3386243386243, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=27.7566539923954, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI210032110, Length=196, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40548397, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI214010158, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI214010156, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI22758144, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=25.8964143426295, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=27.4725274725275, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=25.6281407035176, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=99.2063492063492, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=32.2175732217573, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=30.9236947791165, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=28.1124497991968, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786701, Length=206, Percent_Identity=30.0970873786408, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789208, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=22.7678571428571, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786812, Length=202, Percent_Identity=25.7425742574257, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=30, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=219, Percent_Identity=29.2237442922374, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71997402, Length=253, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=211, Percent_Identity=27.9620853080569, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=200, Percent_Identity=33.5, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=199, Percent_Identity=30.1507537688442, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=234, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=30.4812834224599, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17570069, Length=203, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=201, Percent_Identity=26.3681592039801, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=205, Percent_Identity=29.7560975609756, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=271, Percent_Identity=24.7232472324723, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=26.1044176706827, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=29.5, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=191, Percent_Identity=28.2722513089005, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560176, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=184, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=239, Percent_Identity=24.6861924686192, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=217, Percent_Identity=27.1889400921659, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=193, Percent_Identity=26.4248704663212, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=203, Percent_Identity=25.615763546798, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=211, Percent_Identity=24.6445497630332, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=207, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=212, Percent_Identity=26.8867924528302, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=236, Percent_Identity=26.271186440678, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=215, Percent_Identity=29.3023255813954, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=226, Percent_Identity=27.4336283185841, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=194, Percent_Identity=26.8041237113402, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=28.5140562248996, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=31.6326530612245, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=28.1746031746032, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640492, Length=182, Percent_Identity=30.2197802197802, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24643142, Length=205, Percent_Identity=35.1219512195122, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=30.1435406698565, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=26.1044176706827, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=26.5873015873016, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281364892, Length=204, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45553409, Length=217, Percent_Identity=27.1889400921659, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647948, Length=217, Percent_Identity=27.1889400921659, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647946, Length=217, Percent_Identity=27.1889400921659, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27941; Mature: 27941

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLHQVASHINEET
CCCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
GRQPQWFILDLLTCTSENCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRANAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCCEEECCCCCCCCHHHHCCCHHHHEEEEEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC
>Mature Secondary Structure
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLHQVASHINEET
CCCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
GRQPQWFILDLLTCTSENCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRANAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCCEEECCCCCCCCHHHHCCCHHHHEEEEEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]