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The map label for this gene is cvrA

Identifier: 218704708

GI number: 218704708

Start: 1488477

End: 1490213

Strand: Reverse

Name: cvrA

Synonym: ECUMN_1482

Alternate gene names: 218704708

Gene position: 1490213-1488477 (Counterclockwise)

Preceding gene: 218704709

Following gene: 218704706

Centisome position: 28.65

GC content: 53.08

Gene sequence:

>1737_bases
TTGGATGCCACAACAATAATTAGCCTTTTCATCTTAGGATCCATCCTTGTCACCAGCAGTATATTACTTAGTTCATTTTC
TTCCCGTCTTGGCATTCCTATTCTGGTTATTTTTCTGGCGATCGGCATGCTGGCGGGAGTCGATGGCGTCGGCGGTATCC
CGTTTGATAATTACCCCTTCGCCTACATGGTAAGTAACCTGGCGCTGGCGATTATTTTGCTCGACGGCGGGATGCGCACT
CAGGCCAGTTCCTTTCGTGTGGCGTTAGGACCGGCGCTGTCGCTGGCGACGCTGGGCGTGCTTATCACCTCTGGTTTAAC
CGGCATGATGGCGGCGTGGCTGTTTAATCTTGATTTGATTGAAGGCTTATTAATCGGCGCTATCGTCGGCTCCACCGATG
CTGCGGCGGTATTTTCTCTGCTGGGTGGTAAGGGGCTTAACGAACGCGTTGGCTCGACGCTGGAAATTGAATCCGGCAGT
AATGATCCAATGGCGGTCTTTCTGACGATTACCCTGATTGCGATGATCCAGCAGCATGAAAGCAGTGTCAGCTGGATGTT
CGTGGTCGATATTTTGCAGCAATTTGGCCTCGGGATTGTCATCGGTCTTGGCGGTGGTTATTTACTGCTGCAAATGATTA
ATCGCATCGCCCTGCCCGCCGGTTTATATCCATTGCTGGCATTAAGCGGCGGTATTTTAATTTTTGCTTTAACCACGGCG
CTGGAAGGCAGCGGTATTCTGGCTGTTTATCTGTGCGGTTTTCTGCTGGGTAATCGGCCGATTCGCAACCGCTACGGCAT
CCTGCAAAATTTCGACGGCCTCGCCTGGCTGGCGCAAATCGCCATGTTCCTGGTGCTGGGGCTGTTGGTTAACCCAAGCG
ATCTGCTGCCTATTGCCATTCCGGCGCTCATTTTGTCCGCATGGATGATTTTCTTCGCCCGTCCTCTTTCGGTATTTGCC
GGATTGCTACCGTTCCGTGGTTTTAATCTGCGTGAGCGCGTGTTTATCAGCTGGGTGGGATTACGCGGCGCGGTGCCAAT
CATCCTGGCCGTGTTCCCGATGATGGCGGGGCTGGAGAATGCGCGACTGTTCTTTAATGTCGCCTTCTTTGTGGTTCTGG
TTTCACTGCTCTTGCAGGGAACATCACTCTCGTGGGCGGCGAAAAAAGCCAAAGTGGTCGTTCCGCCAGTGGGACGTCCG
GTGTCACGCGTTGGTCTGGATATTCATCCGGAAAATCCGTGGGAGCAGTTTGTTTATCAGTTGAGTGCCGATAAATGGTG
CGTGGGCGCGGCACTGCGTGATCTGCATATGCCAAAAGAGACGCGTATTGCGGCACTGTTTCGTGATAACCAGTTGCTTC
ATCCTACCGGCAGCACCCGACTGCGCGAAGGCGATGTGTTGTGTGTAATTGGTCGGGAACGCGATCTCCCGGCGCTCGGT
AAACTGTTCAGCCAGTCGCCGCCGGTCGCGCTGGATCAACGCTTCTTTGGTGACTTCATTCTCGAAGCCAGCGCCAAATA
TGCAGATGTGGCGCTGATATATGGCCTGGAAGACGGGCGAGAATATCGTGATAAGCAACAAACGCTGGGTGAAATTGTCC
AGCAGTTGTTAGGCGCGGCACCGGTTGTCGGTGACCAGGTAGAGTTTGCCGGAATGATCTGGACGGTGGCCGAGAAAGAA
GATAATGAAGTGTTGAAGATTGGCGTACGGGTGGCAGAAGAGGAAGCTGAATCTTAA

Upstream 100 bases:

>100_bases
ATGTAAAAAAATCACGCTTCAGGGCTAAGTAAAACGCTGTCTCTGCCGCTAATATGGTAGGGTTTATATAAGAGACAGCG
TAATCAGGAGTAACCGACCG

Downstream 100 bases:

>100_bases
ATTTAATACAGCATCTATCGCCGGATGCGATGCTTTGCGAACGCAGCCTGAGCCTGCATATAAACTTGTCATTTCCTGAT
TTTGATATGCACATTCCAAC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIAMIQQHESSVSWMFVVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFA
GLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNEVLKIGVRVAEEEAES

Sequences:

>Translated_578_residues
MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIAMIQQHESSVSWMFVVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFA
GLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNEVLKIGVRVAEEEAES
>Mature_578_residues
MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIAMIQQHESSVSWMFVVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFA
GLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNEVLKIGVRVAEEEAES

Specific function: Participates in control of cell volume in low-osmolarity conditions

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain

Homologues:

Organism=Escherichia coli, GI87081854, Length=578, Percent_Identity=99.1349480968858, Blast_Score=1134, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CVRA_ECO24 (A7ZKW2)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001462441.1
- ProteinModelPortal:   A7ZKW2
- STRING:   A7ZKW2
- EnsemblBacteria:   EBESCT00000018878
- GeneID:   5589723
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_1336
- eggNOG:   COG3263
- GeneTree:   EBGT00050000010798
- HOGENOM:   HBG359889
- OMA:   SEWELFV
- ProtClustDB:   PRK05326
- BioCyc:   ECOL331111:ECE24377A_1336-MONOMER
- HAMAP:   MF_01075
- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C

EC number: NA

Molecular weight: Translated: 62206; Mature: 62206

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS51202 RCK_C

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x108f898c)-; HASH(0x100c9384)-; HASH(0xff28218)-; HASH(0x10141c48)-; HASH(0x100fff18)-; HASH(0x10143ea8)-; HASH(0x40a68b08)-; HASH(0x107e3824)-; HASH(0x100b9ff0)-; HASH(0x40a657c0)-; HASH(0xfb3df04)-; HASH(0x100d90bc)-; HASH(0x10a3a2bc)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLI
HHHHHHHHEEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQQHE
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
SSVSWMFVVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFALTTA
CCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEHHH
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAI
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHCCCC
ARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRPVSRVGLDIHPENPWEQFVYQ
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEECCCCCCHHHCCCCCCCCCHHHHHHHH
LSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALG
HCCCCHHHHHHHHHHCCCCHHHEEEEECCCEEECCCCCCCEECCCEEEEECCCCCCHHHH
KLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAA
HHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
PVVGDQVEFAGMIWTVAEKEDNEVLKIGVRVAEEEAES
CCCCCCCHHCEEEEEEECCCCCCEEEEHHHHHHCCCCH
>Mature Secondary Structure
MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLI
HHHHHHHHEEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQQHE
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
SSVSWMFVVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFALTTA
CCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEHHH
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAI
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHCCCC
ARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRPVSRVGLDIHPENPWEQFVYQ
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEECCCCCCHHHCCCCCCCCCHHHHHHHH
LSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALG
HCCCCHHHHHHHHHHCCCCHHHEEEEECCCEEECCCCCCCEECCCEEEEECCCCCCHHHH
KLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAA
HHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
PVVGDQVEFAGMIWTVAEKEDNEVLKIGVRVAEEEAES
CCCCCCCHHCEEEEEEECCCCCCEEEEHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA