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The map label for this gene is rutG [H]

Identifier: 218704423

GI number: 218704423

Start: 1241415

End: 1242851

Strand: Reverse

Name: rutG [H]

Synonym: ECUMN_1189

Alternate gene names: 218704423

Gene position: 1242851-1241415 (Counterclockwise)

Preceding gene: 218704424

Following gene: 218704420

Centisome position: 23.89

GC content: 54.49

Gene sequence:

>1437_bases
TTGCGCCATCGAAGCGATTCATCGTCACGCCACACCCTACGGGCTGGTGTGGTTCGATCGCAGTTATCACGCGCTGATGC
GCCCTGCTTGTTAACCTCCTTAAGGAGACAGCTGATGGCAATGTTCGGTCTTCCTCACTGGCAGTTAAAATCGACCTCTA
CAGAGAGCGGCGTGGTCGCGCCGGATGAACGATTGCCGTTTGCTCAGACGGCAATAATGGGCGTTCAACACGCGGTGGCG
ATGTTTGGCGCGACGGTGTTAATGCCGATTCTGATGGGGCTGGATCCCAATCTTTCCATTTTAATGTCAGGGATCGGCAC
GTTACTGTTTTTCTTTATTACCGGCGGGCGCGTGCCCAGTTATCTCGGCTCCAGCGCGGCTTTTGTCGGCGTGGTGATCG
CCGCAACGGGCTTTAACGGTCAGGGCATTAACCCGAATATCAGCATTGCGCTGGGCGGGATTATCGCCTGTGGGCTGGTT
TATACCGTCATTGGCCTGGTGGTGATGAAAATCGGTACGCGCTGGATTGAACGGCTAATGCCGCCGGTGGTGACGGGTGC
GGTGGTGATGGCGATTGGCCTGAACTTAGCGCCTATCGCAGTGAAAAGTGTATCGGCTTCGGCCTTTGATAGCTGGATGG
CGGTAATGACGGTGCTGTGTATTGGGCTGGTGGCGGTGTTTACCCGTGGCATGATCCAGCGATTATTGATTCTCGTAGGA
TTAATTGTCGCCTGTCTGCTGTATGGCGTGATGACCAACGTTTTAGGGCTGGGAAAAGCCGTCGATTTTACTCTCGTCAG
CCATGCTGCCTGGTTCGGTCTGCCGCATTTTTCCACTCCTGCTTTTAATGGTCAGGCAATGATGCTGATTGCGCCCGTGG
CGGTGATTCTGGTGGCGGAAAACTTAGGTCATCTCAAGGCGGTCGCCGGGATGACCGGACGCAATATGGACCCGTATATG
GGGCGAGCATTCGTAGGCGATGGTCTGGCAACGATGCTTTCCGGCTCTGTCGGCGGTAGCGGCGTGACCACCTATGCTGA
AAATATCGGTGTGATGGCCGTGACCAAAGTCTACTCGACGCTGGTGTTTGTTGCTGCTGCCGTCATCGCCATGCTGTTGG
GCTTTTCGCCGAAATTTGGCGCGCTGATCCATACCATTCCTGCACCGGTGATTGGTGGTGCATCAATTGTTGTGTTCGGG
CTGATTGCCGTCGCAGGCGCAAGGATCTGGGTACAAAACCGTGTCGATTTAAGCCAGAACGGTAATTTGATTATGGTCGC
AGTAACCTTAGTGCTGGGCGCGGGTGATTTTGCTCTCACGCTGGGCGGTTTTACGTTGGGAGGGATCGGTACAGCAACCT
TTGGCGCGATTTTACTCAATGCGTTGTTAAGCAGAAGGTTGGTTGACGTTCCACCGCCAGAAGTTGTTCATCAGTAG

Upstream 100 bases:

>100_bases
AGACTGGTGTGACCGGATGCCCGCAACTGGAAGAGGCACTGGTTTCGTTTGACTGCCGTATCAGCCAGGTGGTGAGCGTC
GGCACCCACGACATTCTGTT

Downstream 100 bases:

>100_bases
CCATAAATAGAAAACCGCCGGGGTAACCGGCGGTGATGACTTTTTGACGAGCTTCAGACAAAAATGCATGCGTCATTGAT
TAGCCCGGCTAGTTGTCGCT

Product: pyrimidine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRHRSDSSSRHTLRAGVVRSQLSRADAPCLLTSLRRQLMAMFGLPHWQLKSTSTESGVVAPDERLPFAQTAIMGVQHAVA
MFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLV
YTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVG
LIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYM
GRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAPVIGGASIVVFG
LIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRRLVDVPPPEVVHQ

Sequences:

>Translated_478_residues
MRHRSDSSSRHTLRAGVVRSQLSRADAPCLLTSLRRQLMAMFGLPHWQLKSTSTESGVVAPDERLPFAQTAIMGVQHAVA
MFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLV
YTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVG
LIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYM
GRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAPVIGGASIVVFG
LIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRRLVDVPPPEVVHQ
>Mature_478_residues
MRHRSDSSSRHTLRAGVVRSQLSRADAPCLLTSLRRQLMAMFGLPHWQLKSTSTESGVVAPDERLPFAQTAIMGVQHAVA
MFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLV
YTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVG
LIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYM
GRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAPVIGGASIVVFG
LIAVAGARIWVQNRVDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRRLVDVPPPEVVHQ

Specific function: May function as a proton-driven pyrimidine uptake system [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081818, Length=440, Percent_Identity=99.0909090909091, Blast_Score=852, Evalue=0.0,
Organism=Escherichia coli, GI1788843, Length=425, Percent_Identity=36.9411764705882, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082181, Length=457, Percent_Identity=26.0393873085339, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082178, Length=407, Percent_Identity=26.5356265356265, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790087, Length=402, Percent_Identity=23.3830845771144, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993493, Length=174, Percent_Identity=34.4827586206897, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17542260, Length=174, Percent_Identity=34.4827586206897, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17542262, Length=176, Percent_Identity=31.25, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=181, Percent_Identity=30.3867403314917, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=175, Percent_Identity=29.7142857142857, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356175, Length=176, Percent_Identity=30.6818181818182, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019918
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49667; Mature: 49667

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHRSDSSSRHTLRAGVVRSQLSRADAPCLLTSLRRQLMAMFGLPHWQLKSTSTESGVVA
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCC
PDERLPFAQTAIMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHH
YLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLM
HHCCCHHHHHHHHEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVG
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAE
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYST
CCCHHHHHHCCCCCCCCCHHCHHHHCCCHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHH
LVFVAAAVIAMLLGFSPKFGALIHTIPAPVIGGASIVVFGLIAVAGARIWVQNRVDLSQN
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCC
GNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRRLVDVPPPEVVHQ
CCEEEEEHHHHHCCCCCEEEECCEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure
MRHRSDSSSRHTLRAGVVRSQLSRADAPCLLTSLRRQLMAMFGLPHWQLKSTSTESGVVA
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCC
PDERLPFAQTAIMGVQHAVAMFGATVLMPILMGLDPNLSILMSGIGTLLFFFITGGRVPS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHH
YLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACGLVYTVIGLVVMKIGTRWIERLM
HHCCCHHHHHHHHEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTVLCIGLVAVFTRGMIQRLLILVG
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFSTPAFNGQAMMLIAPVAVILVAE
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVGGSGVTTYAENIGVMAVTKVYST
CCCHHHHHHCCCCCCCCCHHCHHHHCCCHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHH
LVFVAAAVIAMLLGFSPKFGALIHTIPAPVIGGASIVVFGLIAVAGARIWVQNRVDLSQN
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCC
GNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAILLNALLSRRLVDVPPPEVVHQ
CCEEEEEHHHHHCCCCCEEEECCEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]