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The map label for this gene is deoR [H]

Identifier: 218704264

GI number: 218704264

Start: 1064896

End: 1065654

Strand: Reverse

Name: deoR [H]

Synonym: ECUMN_1030

Alternate gene names: 218704264

Gene position: 1065654-1064896 (Counterclockwise)

Preceding gene: 218704265

Following gene: 218704262

Centisome position: 20.49

GC content: 50.07

Gene sequence:

>759_bases
ATGGAAACACGTCGCGAAGAGCGTATCGGGCAGCTGCTGCAAGAATTAAAACGCAGCGATAAGTTACATCTTAAAGACGC
CGCCGCCCTGCTTGGGGTTTCGGAGATGACGATTCGTCGCGATCTGAACAACCACAGTGCGCCCGTCGTTTTGCTCGGCG
GCTATATTGTTCTGGAACCGCGCAGTGCCAGCCATTATCTGTTAAGCGATCAAAAATCCCGCCTGGTGGAAGAAAAACGC
CGGGCGGCAAAACTGGCTGCGACGCTGGTAGAACCCGATCAGACCCTCTTTTTTGACTGTGGCACCACCACACCGTGGAT
TATTGAAGCGATTGATAATGAAATCCCTTTCACCGCCGTTTGTTATTCGCTAAATACCTTTCTGGCACTGAAAGAGAAAC
CTCATTGCCGCGCGTTTCTTTGCGGTGGTGAATTTCACGCCAGCAACGCCATTTTCAAACCCATCGATTTTCAGCAAACG
CTGAATAATTTTTGCCCGGATATCGCTTTTTATTCCGCGGCGGGGGTGCATGTCAGTAAGGGCGCTACCTGTTTTAATCT
TGAAGAGTTGCCGGTAAAACACTGGGCCATGTCGATGGCGCAAAAGCATGTGCTGGTTGTCGACCACAGTAAATTTGGCA
AGGTGCGTCCGGCGCGCATGGGTGACCTGAAACGCTTTGATATTATGGTAAGCGATTGTTGCCCGGAAGATGAATATGTG
AAGTACGCGCAGACGCAGCGTATTAAGTTGATGTATTAA

Upstream 100 bases:

>100_bases
CTGTTTTGCATTACCGATCCGCAAAGGCTGGGTGCGTGACTGATCTCTGCTAAAAAGTGTAGTATTGAGCGGCTCGCTTC
AATAACTATTCAGAGGGATT

Downstream 100 bases:

>100_bases
TGACGTATAACCGGATGACGTTTCGCGCCATCCGGTTATCAGAAGATTAAGAGAACCAGCTGCCGAACCACTGATGGAAT
TTCATCATCACGAAATCCCA

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQT
LNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIMVSDCCPEDEYV
KYAQTQRIKLMY

Sequences:

>Translated_252_residues
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQT
LNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIMVSDCCPEDEYV
KYAQTQRIKLMY
>Mature_252_residues
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQT
LNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIMVSDCCPEDEYV
KYAQTQRIKLMY

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=252, Percent_Identity=99.6031746031746, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI1789519, Length=240, Percent_Identity=27.5, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789829, Length=253, Percent_Identity=26.4822134387352, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790753, Length=243, Percent_Identity=23.8683127572016, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788069, Length=250, Percent_Identity=21.2, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1787540, Length=233, Percent_Identity=26.1802575107296, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI226510968, Length=210, Percent_Identity=30.4761904761905, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789059, Length=231, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28580; Mature: 28580

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEP
CCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECC
RSASHYLLSDQKSRLVEEKRRAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHEECCCCCCHHHH
CYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQTLNNFCPDIAFYSAAGVHVSK
HHHHHHHEEECCCCCCEEEEECCEEECCCCEECCCCHHHHHHHHCCCHHHHHCCCEEEEC
GATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIMVSDCCPEDEYV
CCEEECHHHCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCCHHHEEEEECCCCCHHHH
KYAQTQRIKLMY
HHHCCCEEEEEC
>Mature Secondary Structure
METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEP
CCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECC
RSASHYLLSDQKSRLVEEKRRAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHEECCCCCCHHHH
CYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQTLNNFCPDIAFYSAAGVHVSK
HHHHHHHEEECCCCCCEEEEECCEEECCCCEECCCCHHHHHHHHCCCHHHHHCCCEEEEC
GATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIMVSDCCPEDEYV
CCEEECHHHCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCCHHHEEEEECCCCCHHHH
KYAQTQRIKLMY
HHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]