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The map label for this gene is yjcE [H]

Identifier: 218703051

GI number: 218703051

Start: 5035548

End: 5037221

Strand: Direct

Name: yjcE [H]

Synonym: ECIAI39_4829

Alternate gene names: 218703051

Gene position: 5035548-5037221 (Clockwise)

Preceding gene: 218703047

Following gene: 218703059

Centisome position: 98.12

GC content: 47.43

Gene sequence:

>1674_bases
ATGAGGAAGCCTGTTTATTATATGGAAATACTTTTAACAATTTTAATTCTTACGTTGGTAGTATCATTAACCAGCGTGCT
TACACGTCTGTCTCCTGTCCAGATACCACTTCCTTTAATCCAGATTGCCGCTGGTGCAGTACTGGCCCAGCCTATATTTG
GTCTGCATGTGGAATTCAATCCTGAACTTTTTCTCTTATTGTTTATACCACCCCTGTTGTTTGCTGAAAGTTCAAAAATA
CAACCTAAAGAATTGATCAAGCACAGCCGGGAAATTATCAGCCTGGCACTTGTGTTGGTACTAATCACTATTTTTGGTGT
CGGCTATGTGATTCATTTACTCTTACCGAATGTGCCGCTCATCGCTGCTTTCGCATTAGCCGCCGTGTTGTCGCCTACCG
ATGCCGTGGCGTTGCTGGGGATTGTCGGGAAAGGGCGTATCAGCAAAAACATCCAGGAAGTGCTCGAAGGCGAAGCGTTG
ATGAATGATGCTTCCGGCCTGGTGGCGTTGAAATTTGCTGTTGCAGTGACGATGGGAACGATGGAATTCAGCGTTCATGG
CGCAACCATTGCGTTTTTTGTCGTTGCGTTGGGCGGTATTGCCGTGGGGATCGCTGTTACCTGGTTATATGGTAAAGGGC
TGCTGTTGATCAGCCGATATGCTCACGATGAACCTTCCATTCAGATTGTATTGATGCTTCTGTTGCCGTTTATTGTTTAT
CTGGTTGCGGAACATTTTGGCTTATCTGGCATTCTTGCCGCTGTCGCCGCGGGGTTAACAACCAGTCGCATTGGCGTAGT
CCACCACGCGCCTATTCGCCTGAGAATTAAAGCTAAAAGTAGCTGGTCGATGCTTGAATATGTCTTTAACGGCATGGTGT
TTCTGATTTTAGGCTTACAACTGCCGGGCATTATTTCGGAATCACTGATCCGTGCAGAAAACGATCCACTGGTGGACACC
GGATCGCTGCTCCTTGATGTCATTTGGATCTACCTGGCGTTAATGGTTGTGCGCCTGGGCTGGCTTTGGCTGATGCGTCT
GTATAGCCGTAAACGACCCGGCAAACATCCGATGCTGTTTGCTGGATATAAAACGCGTCATATGCTGCTGGCGACCTTTG
CGGGGGTGCGCGGAGCTATCACGCTTGCGGGGGTGCTTTCTATCCCGTTATTGCTGCCGGATGGCACACCTTTTCCCGGG
CGTTACTTGCTGGTATTTCTCGCTACAGGTGTGATCCTCTTTTCGCTGGTTTGCGGCATTATTATTCTGCCGTTATTACT
AGGGAAAAATGTGGGGATTTTCAGCGATAACCGACAAAAAGAAGAGGAAGCTGCCGATCTGTTTATGGCTAAAATGTCCA
TACTGAGTGTGCAAAAGACCGAGCAACGTTTGCTGCGCGCCAGAACAGAAAACCTCGATAACGAGTTGATTATGGAAACG
GGGGCCAGAGTTATCGGTTATATGCGACATAGTGAAGAGGATATGTCGCCTAATGATAATTCCCTGCATATGCAGCGTGC
GAAGCTGGAAAGAACATTTAATCTGGCGGCGTTAAATGCCAAACGTGCGGCTATTTACCAGATGCGCGCAAGGCAAGAAG
TCAGTGATGAAACACTGGCAAAAATAGTCAGTGAATTAGATGTGCTGGAAACGTTAATCATGGATAGCCGATAA

Upstream 100 bases:

>100_bases
CTTCTGATCATGTGAGTGAACGCAGTGATTAATGATTAACGTTAAGTGCTAACCAGAGCGCTTTTTATGAAGTTAAATTA
ATAATATCCATTATTTATGA

Downstream 100 bases:

>100_bases
TTTTATCGCTGCCAGTAATAGGGAATTAAATGATGGCTGAGAGTAATACTTTCAGCATCGTTTATTCCCTATGTATTTCC
TTATGGGCAGAACAATCGCC

Product: putative Na(+)/H(+) exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MRKPVYYMEILLTILILTLVVSLTSVLTRLSPVQIPLPLIQIAAGAVLAQPIFGLHVEFNPELFLLLFIPPLLFAESSKI
QPKELIKHSREIISLALVLVLITIFGVGYVIHLLLPNVPLIAAFALAAVLSPTDAVALLGIVGKGRISKNIQEVLEGEAL
MNDASGLVALKFAVAVTMGTMEFSVHGATIAFFVVALGGIAVGIAVTWLYGKGLLLISRYAHDEPSIQIVLMLLLPFIVY
LVAEHFGLSGILAAVAAGLTTSRIGVVHHAPIRLRIKAKSSWSMLEYVFNGMVFLILGLQLPGIISESLIRAENDPLVDT
GSLLLDVIWIYLALMVVRLGWLWLMRLYSRKRPGKHPMLFAGYKTRHMLLATFAGVRGAITLAGVLSIPLLLPDGTPFPG
RYLLVFLATGVILFSLVCGIIILPLLLGKNVGIFSDNRQKEEEAADLFMAKMSILSVQKTEQRLLRARTENLDNELIMET
GARVIGYMRHSEEDMSPNDNSLHMQRAKLERTFNLAALNAKRAAIYQMRARQEVSDETLAKIVSELDVLETLIMDSR

Sequences:

>Translated_557_residues
MRKPVYYMEILLTILILTLVVSLTSVLTRLSPVQIPLPLIQIAAGAVLAQPIFGLHVEFNPELFLLLFIPPLLFAESSKI
QPKELIKHSREIISLALVLVLITIFGVGYVIHLLLPNVPLIAAFALAAVLSPTDAVALLGIVGKGRISKNIQEVLEGEAL
MNDASGLVALKFAVAVTMGTMEFSVHGATIAFFVVALGGIAVGIAVTWLYGKGLLLISRYAHDEPSIQIVLMLLLPFIVY
LVAEHFGLSGILAAVAAGLTTSRIGVVHHAPIRLRIKAKSSWSMLEYVFNGMVFLILGLQLPGIISESLIRAENDPLVDT
GSLLLDVIWIYLALMVVRLGWLWLMRLYSRKRPGKHPMLFAGYKTRHMLLATFAGVRGAITLAGVLSIPLLLPDGTPFPG
RYLLVFLATGVILFSLVCGIIILPLLLGKNVGIFSDNRQKEEEAADLFMAKMSILSVQKTEQRLLRARTENLDNELIMET
GARVIGYMRHSEEDMSPNDNSLHMQRAKLERTFNLAALNAKRAAIYQMRARQEVSDETLAKIVSELDVLETLIMDSR
>Mature_557_residues
MRKPVYYMEILLTILILTLVVSLTSVLTRLSPVQIPLPLIQIAAGAVLAQPIFGLHVEFNPELFLLLFIPPLLFAESSKI
QPKELIKHSREIISLALVLVLITIFGVGYVIHLLLPNVPLIAAFALAAVLSPTDAVALLGIVGKGRISKNIQEVLEGEAL
MNDASGLVALKFAVAVTMGTMEFSVHGATIAFFVVALGGIAVGIAVTWLYGKGLLLISRYAHDEPSIQIVLMLLLPFIVY
LVAEHFGLSGILAAVAAGLTTSRIGVVHHAPIRLRIKAKSSWSMLEYVFNGMVFLILGLQLPGIISESLIRAENDPLVDT
GSLLLDVIWIYLALMVVRLGWLWLMRLYSRKRPGKHPMLFAGYKTRHMLLATFAGVRGAITLAGVLSIPLLLPDGTPFPG
RYLLVFLATGVILFSLVCGIIILPLLLGKNVGIFSDNRQKEEEAADLFMAKMSILSVQKTEQRLLRARTENLDNELIMET
GARVIGYMRHSEEDMSPNDNSLHMQRAKLERTFNLAALNAKRAAIYQMRARQEVSDETLAKIVSELDVLETLIMDSR

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=470, Percent_Identity=23.1914893617021, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI148727259, Length=462, Percent_Identity=23.5930735930736, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27734935, Length=427, Percent_Identity=22.7166276346604, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI14211919, Length=347, Percent_Identity=20.7492795389049, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI41872703, Length=317, Percent_Identity=23.9747634069401, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4759144, Length=258, Percent_Identity=27.1317829457364, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790501, Length=550, Percent_Identity=58.1818181818182, Blast_Score=616, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71992101, Length=342, Percent_Identity=24.8538011695906, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71992107, Length=342, Percent_Identity=24.8538011695906, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=385, Percent_Identity=25.4545454545455, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25150332, Length=387, Percent_Identity=24.2894056847545, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71999819, Length=436, Percent_Identity=23.6238532110092, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=436, Percent_Identity=23.6238532110092, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999821, Length=413, Percent_Identity=23.4866828087167, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=313, Percent_Identity=23.3226837060703, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=256, Percent_Identity=23.4375, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221473215, Length=462, Percent_Identity=22.0779220779221, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281364513, Length=343, Percent_Identity=23.0320699708455, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473212, Length=343, Percent_Identity=23.0320699708455, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473222, Length=343, Percent_Identity=23.0320699708455, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510734, Length=445, Percent_Identity=23.8202247191011, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510738, Length=445, Percent_Identity=23.8202247191011, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510732, Length=445, Percent_Identity=23.8202247191011, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221510736, Length=445, Percent_Identity=23.8202247191011, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585580, Length=445, Percent_Identity=23.8202247191011, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24585578, Length=445, Percent_Identity=23.8202247191011, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI221510740, Length=445, Percent_Identity=23.8202247191011, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 61159; Mature: 61159

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPVYYMEILLTILILTLVVSLTSVLTRLSPVQIPLPLIQIAAGAVLAQPIFGLHVEFN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHEEEEEEC
PELFLLLFIPPLLFAESSKIQPKELIKHSREIISLALVLVLITIFGVGYVIHLLLPNVPL
CCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IAAFALAAVLSPTDAVALLGIVGKGRISKNIQEVLEGEALMNDASGLVALKFAVAVTMGT
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCC
MEFSVHGATIAFFVVALGGIAVGIAVTWLYGKGLLLISRYAHDEPSIQIVLMLLLPFIVY
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHCCCCCCHHHHHHHHHHHHHH
LVAEHFGLSGILAAVAAGLTTSRIGVVHHAPIRLRIKAKSSWSMLEYVFNGMVFLILGLQ
HHHHHCCHHHHHHHHHHCCHHHHCCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHC
LPGIISESLIRAENDPLVDTGSLLLDVIWIYLALMVVRLGWLWLMRLYSRKRPGKHPMLF
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
AGYKTRHMLLATFAGVRGAITLAGVLSIPLLLPDGTPFPGRYLLVFLATGVILFSLVCGI
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IILPLLLGKNVGIFSDNRQKEEEAADLFMAKMSILSVQKTEQRLLRARTENLDNELIMET
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GARVIGYMRHSEEDMSPNDNSLHMQRAKLERTFNLAALNAKRAAIYQMRARQEVSDETLA
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHH
KIVSELDVLETLIMDSR
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKPVYYMEILLTILILTLVVSLTSVLTRLSPVQIPLPLIQIAAGAVLAQPIFGLHVEFN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHEEEEEEC
PELFLLLFIPPLLFAESSKIQPKELIKHSREIISLALVLVLITIFGVGYVIHLLLPNVPL
CCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IAAFALAAVLSPTDAVALLGIVGKGRISKNIQEVLEGEALMNDASGLVALKFAVAVTMGT
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCC
MEFSVHGATIAFFVVALGGIAVGIAVTWLYGKGLLLISRYAHDEPSIQIVLMLLLPFIVY
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHCCCCCCHHHHHHHHHHHHHH
LVAEHFGLSGILAAVAAGLTTSRIGVVHHAPIRLRIKAKSSWSMLEYVFNGMVFLILGLQ
HHHHHCCHHHHHHHHHHCCHHHHCCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHC
LPGIISESLIRAENDPLVDTGSLLLDVIWIYLALMVVRLGWLWLMRLYSRKRPGKHPMLF
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
AGYKTRHMLLATFAGVRGAITLAGVLSIPLLLPDGTPFPGRYLLVFLATGVILFSLVCGI
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IILPLLLGKNVGIFSDNRQKEEEAADLFMAKMSILSVQKTEQRLLRARTENLDNELIMET
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GARVIGYMRHSEEDMSPNDNSLHMQRAKLERTFNLAALNAKRAAIYQMRARQEVSDETLA
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHH
KIVSELDVLETLIMDSR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]