Click here to switch to the map view.

The map label for this gene is fimB

Identifier: 218703010

GI number: 218703010

Start: 4988411

End: 4989013

Strand: Direct

Name: fimB

Synonym: ECIAI39_4784

Alternate gene names: 218703010

Gene position: 4988411-4989013 (Clockwise)

Preceding gene: 218703001

Following gene: 218703011

Centisome position: 97.2

GC content: 43.45

Gene sequence:

>603_bases
ATGAAGAATAAGGCTGATAACAAAAAAAGGAACTTCCTGACCCATAGTGAAATCGAATCATTCCTTAAAGCAGCAAATAC
CGGGCCTCATGCAGCACGTAATTATTGTCTGACTTTGCTTTGTTTTATTCATGGTTTCCGGGCGAGTGAAATTTGTCGAT
TGAGGATTTCGGATATTGATCTTAAGGCAAAGTGTATATATATCCATCGATTAAAAAAAGGCTTTTCAACAACGCATCCG
CTATTGAACAAAGAAGTTCAGGCTTTAAAAAACTGGTTGAGTATCCGTACTTCGTACCCGCATGCTGAGAGCGAGTGGGT
ATTTTTATCGCGTAAGGGGAATCCGCTTTCTCGGCAACAGTTTTACCATATTATCTCGACTTCCGGTGGTAATGCCGGGT
TGTCACTGGAGATTCATCCGCACATGTTACGCCATTCGTGTGGTTTTGCTTTGGCGAATATGGGAATAGATACGCGACTT
ATCCAGGATTATCTTGGGCATCGCAATATTCGTCATACTGTCTGGTATACCGCCAGCAATGCAGGGCGTTTTTACGGCAT
CTGGGATAGAGCCAGAGGACGACAGCGTCACGCTGTTTTATAG

Upstream 100 bases:

>100_bases
AAGCAAACGTTCGCTTTTATAAACATAATCAGGATAAAAATGTTGGATTATTGCTAACCCAGCACAGCTAGTGCGCGTCT
GTAATTATAAGGGAAAAACG

Downstream 100 bases:

>100_bases
AGATAGTTGAGATACCAGGGATGGTGTTAAAAACTACATTATTCTTACGATATATCAAAAATGATTAACCATTTATTAAT
TGATGTTATTGTAAGTGTGA

Product: tyrosine recombinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MKNKADNKKRNFLTHSEIESFLKAANTGPHAARNYCLTLLCFIHGFRASEICRLRISDIDLKAKCIYIHRLKKGFSTTHP
LLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRHSCGFALANMGIDTRL
IQDYLGHRNIRHTVWYTASNAGRFYGIWDRARGRQRHAVL

Sequences:

>Translated_200_residues
MKNKADNKKRNFLTHSEIESFLKAANTGPHAARNYCLTLLCFIHGFRASEICRLRISDIDLKAKCIYIHRLKKGFSTTHP
LLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRHSCGFALANMGIDTRL
IQDYLGHRNIRHTVWYTASNAGRFYGIWDRARGRQRHAVL
>Mature_200_residues
MKNKADNKKRNFLTHSEIESFLKAANTGPHAARNYCLTLLCFIHGFRASEICRLRISDIDLKAKCIYIHRLKKGFSTTHP
LLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRHSCGFALANMGIDTRL
IQDYLGHRNIRHTVWYTASNAGRFYGIWDRARGRQRHAVL

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=200, Percent_Identity=99.5, Blast_Score=415, Evalue=1e-118,
Organism=Escherichia coli, GI1790768, Length=183, Percent_Identity=52.4590163934426, Blast_Score=197, Evalue=4e-52,
Organism=Escherichia coli, GI1790244, Length=182, Percent_Identity=26.3736263736264, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 23028; Mature: 23028

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKADNKKRNFLTHSEIESFLKAANTGPHAARNYCLTLLCFIHGFRASEICRLRISDID
CCCCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
LKAKCIYIHRLKKGFSTTHPLLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQ
CEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHH
FYHIISTSGGNAGLSLEIHPHMLRHSCGFALANMGIDTRLIQDYLGHRNIRHTVWYTASN
HEEHEECCCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECC
AGRFYGIWDRARGRQRHAVL
CCCEEEEHHHCCCCCCCCCC
>Mature Secondary Structure
MKNKADNKKRNFLTHSEIESFLKAANTGPHAARNYCLTLLCFIHGFRASEICRLRISDID
CCCCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
LKAKCIYIHRLKKGFSTTHPLLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQ
CEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHH
FYHIISTSGGNAGLSLEIHPHMLRHSCGFALANMGIDTRLIQDYLGHRNIRHTVWYTASN
HEEHEECCCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECC
AGRFYGIWDRARGRQRHAVL
CCCEEEEHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]