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The map label for this gene is soxR

Identifier: 218702728

GI number: 218702728

Start: 4686482

End: 4686946

Strand: Direct

Name: soxR

Synonym: ECIAI39_4484

Alternate gene names: 218702728

Gene position: 4686482-4686946 (Clockwise)

Preceding gene: 218702726

Following gene: 218702729

Centisome position: 91.32

GC content: 51.61

Gene sequence:

>465_bases
ATGGAAAAGAAATTACCCCGCATTAAAGCGCTGCTAACCCCCGGCGAAGTGGCGAAACGCAGCGGTGTGGCGGTATCGGC
GCTGCATTTCTATGAAAGCAAAGGGTTGATTAGCAGTATCCGTAATAGTGGCAATCAGCGGCGATATAAACGTGATGTGT
TGCGATATGTCGCAATCATCAAAATTGCTCAGCGTATTGGCATTCCGCTCGCAACCATTCGTGAAGCATTTGGCGTGTTG
CCCGAAGGGCATACATTAAGTGCGAAAGAGTGGAAACAGCTTTCGTCCCAATGGCGAGAAGAGTTGGATCGGCGCATTCA
TACCTTAGTGGCGCTGCGTGACGAGCTGGACGGATGTATTGGTTGTGGCTGCCTTTCGCGCAGTGATTGCCCATTGCGTA
ACCCGGGCGACCGCTTAGGAGAAGAAGGCACAGGCGCACGCTTGCTGGAAGATGAACAAAACTAA

Upstream 100 bases:

>100_bases
TTTCTGATGGGACATAAATCTGCCTCTTTTCAGTGTTCAGTTCGTTAATTCATCTGTTGGGGAGTATAATTCCTCAAGTT
AACTTGAGGTAAAGCGATTT

Downstream 100 bases:

>100_bases
AGCGCCACAAGGGCGCTTTAGTTTGTTTTCCGGTCTTTGTCTTTCTCTCTATCCCGCTGGTACACAGGAGGGTTTCCCCC
GACGTCAACACACCTCATTC

Product: DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLISSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIREAFGVL
PEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Sequences:

>Translated_154_residues
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLISSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIREAFGVL
PEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN
>Mature_154_residues
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLISSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIREAFGVL
PEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=154, Percent_Identity=98.7012987012987, Blast_Score=309, Evalue=6e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 17235; Mature: 17235

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLISSIRNSGNQRRYKRDVLRYVAII
CCCCCCHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KIAQRIGIPLATIREAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCI
HHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN
HCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLISSIRNSGNQRRYKRDVLRYVAII
CCCCCCHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KIAQRIGIPLATIREAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCI
HHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN
HCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]