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The map label for this gene is hilA [H]

Identifier: 218702501

GI number: 218702501

Start: 4424887

End: 4426584

Strand: Direct

Name: hilA [H]

Synonym: ECIAI39_4257

Alternate gene names: 218702501

Gene position: 4424887-4426584 (Clockwise)

Preceding gene: 218702500

Following gene: 218702505

Centisome position: 86.22

GC content: 35.51

Gene sequence:

>1698_bases
ATGCAACTGCAACATGGAAAAAATAATACACAACAATATATATTTGGCGACTTTGTATTAAAAAACAATGGAATATTATT
ATTCAAAAACAAAGAATATCATATTCCCCCGAAAGAACTTGGCGTTATCATTCTATTACTTAATGCTGACGGTGAAATTG
TTAGCAAAGAAGAGATTATCGATAAGGTCTGGAGCGCGAGTGTTGCCAGTGATGAATCTCTAACACGATGTATTTATGCA
TTGCGCAAACTTTTGCATGAGAATAAACAGTGTAAGTATATCGAAACGGTCTATGGTCGTGGATACCGTTTTACTGTACC
TATTGTGATTGTGACCGATAATGAACCGGTAAAGTCGACCACCACTCTTGCCGTTTTTCCCTTTCGTACTGAAGGTTCGA
TCAATGTTCTAAAACTCCATTACGAACTTGTCCAGGGCCTTTCAAAATATGCTTTTTGTGGTTTAGATATTTTACCCGCT
TCGGTAACAAATGAGGCCAGTGATTTCTCCACCATCCATCAGTTTATCAATAAAATAGGTCCAGAATATTATATTATGGG
TCAGGTCGTTCACTATGGTAAAAACTGGCGTTTATTTATTGAGTTAATCCATGCCAGAACGCATAAATTGATTGATCATC
AAAGTATTGATTTCAACCCCGATAATCCTCTTTCCGTATTATTATCACAAGTAATTAATATTCTTATTGAAAAAATACCC
AACATTAATTTTAAATCTATTAATACACAACAAATGCCATCTCTGGATTCTGCTGTTATGTATATGAATGGCAGGATGGA
AATGTACCGTTATACACCAGAAAGTTTGAAACGAGCATTAGTAATATTTAGAGATTGTGTGAGTACGCAACCGCAAAATA
CCTTGCCCTACTGTTGCCTGGCGGAATGCCATATATCATTAGCACTCCTTGGAATCAGTGAACAAAAACAAGCAATAACT
ACGGCAGTAACCTCCATTGAAAAGGCTCTGGAAATTAACCCTTCAAATTCTCAGGCATTGGGTTTACTGGGTTTAATCAG
TGGGCTAAAAGATGAACATTCAGTGTCTAATGTGCTATTTAAGCAAGCACATTTACTCAAACCTAATTCGCCAGACGTTT
ATTATTATCAGTCTCTGCTATGTTTTTTGAACGGTGACCTAGCAAGAGCATTTAATTTAATAGAAAAAAGCATTGCTCTT
GAACCCAATAAAATGGGCATAAGCATTCTTAAATTAATTATACTTTATTACACATCCCCCCTCGATAACGCGATATCTTT
TGCATTAAATCTTAACAGTCAAAACACCTGTAATAATCCAATTATTACCTCTATTCTGGCTATGTTCATGGCACTGAAAG
GACATAATGACAAAGCCAAAAGTTTATTGCTTAAACTTGAGCCTGAACATGGTCTTGATTACACCTGCGTTAACTCGCTT
TATACGAAGTTTCTGATCTATGGCGCATCTATAAAAAATGACATTATGAAGTTACTGGCAAATATTAACACTAACAAAAT
CAATGGTGTGATCTTGCCGTTAATTTACACTGTTTATGGTAAGAAAGAATATGAAAAGCGCTGGCAACAATTAATTAAAG
AGAATGATTTATGGTCAAATGTTTTGCTTCATGACCCCCGTTTACTCAGTGTAAAAAACGAATTTAATACTATTGGTATG
ATGCGTACTTCTGCGTAA

Upstream 100 bases:

>100_bases
CTTACAAAATGAGCGTTTTTTGATAGAGCAATTCTGCCAATACTTTATTTTATATTAATCAAATTAATACTATGAATAGA
GAAAACGGAAGGAGCGTTCT

Downstream 100 bases:

>100_bases
TAACGAATATAAATTGCCCTGCTGATGCAGGGCAATTTAGTAATTACTTCGTTAATAATACTCTACGCACAAGCCAGAAG
ACTTTCCTGTCCCAAGCTCT

Product: invasion protein regulator

Products: NA

Alternate protein names: Protein iagA [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MQLQHGKNNTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYA
LRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPA
SVTNEASDFSTIHQFINKIGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP
NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCLAECHISLALLGISEQKQAIT
TAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIAL
EPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL
YTKFLIYGASIKNDIMKLLANINTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSNVLLHDPRLLSVKNEFNTIGM
MRTSA

Sequences:

>Translated_565_residues
MQLQHGKNNTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYA
LRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPA
SVTNEASDFSTIHQFINKIGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP
NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCLAECHISLALLGISEQKQAIT
TAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIAL
EPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL
YTKFLIYGASIKNDIMKLLANINTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSNVLLHDPRLLSVKNEFNTIGM
MRTSA
>Mature_565_residues
MQLQHGKNNTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEIIDKVWSASVASDESLTRCIYA
LRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKSTTTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPA
SVTNEASDFSTIHQFINKIGPEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP
NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCLAECHISLALLGISEQKQAIT
TAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLFKQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIAL
EPNKMGISILKLIILYYTSPLDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL
YTKFLIYGASIKNDIMKLLANINTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSNVLLHDPRLLSVKNEFNTIGM
MRTSA

Specific function: The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of invF. Also binds upstream o

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TPR repeat [H]

Homologues:

Organism=Escherichia coli, GI1789216, Length=456, Percent_Identity=32.4561403508772, Blast_Score=221, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 63981; Mature: 63981

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLQHGKNNTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEII
CCCCCCCCCCCEEEEEEEEEECCCEEEEECCCCCCCHHHCCEEEEEECCCCCEECHHHHH
DKVWSASVASDESLTRCIYALRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKST
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEEEEEECCCCCCCC
TTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPASVTNEASDFSTIHQFINKIG
EEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHC
PEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP
CCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCL
CCCCCCCCHHHCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AECHISLALLGISEQKQAITTAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLF
HHHHHEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
KQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSP
HHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
LDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEECCCCCCCHHHHHHH
YTKFLIYGASIKNDIMKLLANINTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSN
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
VLLHDPRLLSVKNEFNTIGMMRTSA
HHCCCCEEEEECCCCCCEEEEEECC
>Mature Secondary Structure
MQLQHGKNNTQQYIFGDFVLKNNGILLFKNKEYHIPPKELGVIILLLNADGEIVSKEEII
CCCCCCCCCCCEEEEEEEEEECCCEEEEECCCCCCCHHHCCEEEEEECCCCCEECHHHHH
DKVWSASVASDESLTRCIYALRKLLHENKQCKYIETVYGRGYRFTVPIVIVTDNEPVKST
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEEEEEECCCCCCCC
TTLAVFPFRTEGSINVLKLHYELVQGLSKYAFCGLDILPASVTNEASDFSTIHQFINKIG
EEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHC
PEYYIMGQVVHYGKNWRLFIELIHARTHKLIDHQSIDFNPDNPLSVLLSQVINILIEKIP
CCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NINFKSINTQQMPSLDSAVMYMNGRMEMYRYTPESLKRALVIFRDCVSTQPQNTLPYCCL
CCCCCCCCHHHCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AECHISLALLGISEQKQAITTAVTSIEKALEINPSNSQALGLLGLISGLKDEHSVSNVLF
HHHHHEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
KQAHLLKPNSPDVYYYQSLLCFLNGDLARAFNLIEKSIALEPNKMGISILKLIILYYTSP
HHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
LDNAISFALNLNSQNTCNNPIITSILAMFMALKGHNDKAKSLLLKLEPEHGLDYTCVNSL
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEECCCCCCCHHHHHHH
YTKFLIYGASIKNDIMKLLANINTNKINGVILPLIYTVYGKKEYEKRWQQLIKENDLWSN
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
VLLHDPRLLSVKNEFNTIGMMRTSA
HHCCCCEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA