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The map label for this gene is yicE

Identifier: 218702423

GI number: 218702423

Start: 4346892

End: 4348283

Strand: Direct

Name: yicE

Synonym: ECIAI39_4176

Alternate gene names: 218702423

Gene position: 4346892-4348283 (Clockwise)

Preceding gene: 218702421

Following gene: 218702424

Centisome position: 84.7

GC content: 54.81

Gene sequence:

>1392_bases
ATGTCTGTTTCCACCCTCGAGTCAGAAAATGCGCAACCGGTTGCGCAGACTCAAAACAGCGAACTGATTTACCGTCTTGA
AGATCGTCCGCCGCTTCCTCAAACCCTGTTTGCCGCATGTCAGCATTTGCTGGCGATGTTCGTTGCGGTGATCACGCCAG
CGCTATTAATCTGCCAGGCGCTGGGTTTACCGGCACAAGACACGCAACACATTATTAGTATGTCGCTGTTTGCCTCCGGT
GTGGCATCGATTATTCAAATTAAGGCCTGGGGTCCGGTTGGCTCCGGGTTGTTGTCTATTCAGGGCACCAGCTTCAACTT
TGTTGCTCCGCTGATTATGGGCGGCACAGCGCTGAAGACCGGTGGTGCTGATGTTCCTACCATGATGGCGGCTTTGTTCG
GCACGTTGATGCTGGCAAGTTGTACCGAGATGGTGATCTCCCGCGTTCTGCATCTGGCGCGCCGCATTATTACGCCGCTG
GTTTCTGGCGTTGTGGTGATAATTATCGGCCTGTCGCTAATTCAGGTGGGGCTGACCTCCATTGGCGGCGGTTACGCAGC
CATGAGCGATAACACCTTCGGCGCACCGAAAAATCTGCTGCTGGCAGGCGTGGTCTTAGCCTTAATTATCCTGCTTAACC
GTCAACGTAACCCTTACTTACGCGTGGCCTCACTGGTGATTGCGATGGCGGCCGGATATGCGCTGGCGTGGTTTATGGGC
ATGTTGCCAGAAAGCAACGAACCGATGACACAAGAACTGATTATGGTGCCAACGCCGCTCTATTACGGTCTTGGCATTGA
ATGGAGTCTGCTGCTGCCGCTGATGCTGGTCTTTATGATCACTTCGCTGGAAACCATTGGCGATATCACAGCGACCTCTG
ACGTTTCCGAACAGCCAGTGTCCGGTCCGCTGTACATGAAACGCCTGAAAGGCGGCGTGCTGGCAAACGGCCTGAACTCG
TTTGTTTCGGCGGTATTTAACACCTTCCCGAACTCCTGCTTCGGGCAGAACAACGGTGTGATCCAGTTGACCGGTGTTGC
CAGCCGCTATGTCGGTTTTGTCGTCGCGCTGATGTTGATCGTGCTGGGTCTCTTCCCGGCGGTGAGCGGTTTTGTACAAC
ATATTCCAGAACCGGTTCTGGGCGGCGCAACGCTTGTAATGTTTGGCACCATCGCCGCCTCCGGTGTGCGTATCGTTTCT
CGTGAGCCGCTGAACCGCCGGGCGATTCTGATTATCGCGCTGTCGCTGGCGGTCGGTCTGGGCGTGTCTCAGCAGCCGCT
GATTTTGCAGTTTGCCCCTGAATGGCTGAAAAACCTACTCTCCTCCGGGATTGCCGCGGGCGGTATTACTGCCATCGTGC
TGAATCTGATTTTCCCACCAGAAAAACAGTAA

Upstream 100 bases:

>100_bases
ATTTATCTCATTTAAATATTTAAACGAGGATGTAGCAAACGTTTGCTTTTCTCTTTCGGTCAGCTAAAATGCCCGCTTTG
CTACCACGGGATTGTTTTCG

Downstream 100 bases:

>100_bases
TTCACTGGCGGCGGTAAGATAATTACCGCCGCAGTCTCACCTCTTTCACCATTCCCGCCTTGAGGATTGCGCGTAAATCG
TGCATAACTCCCTTATGTGC

Product: putative transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPL
VSGVVVIIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ

Sequences:

>Translated_463_residues
MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPL
VSGVVVIIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
>Mature_462_residues
SVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASGV
ASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLV
SGVVVIIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMGM
LPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNSF
VSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
EPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=516, Percent_Identity=23.062015503876, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI40316845, Length=516, Percent_Identity=23.062015503876, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790087, Length=463, Percent_Identity=99.7840172786177, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=443, Percent_Identity=45.1467268623025, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=28.695652173913, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788843, Length=444, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081818, Length=405, Percent_Identity=24.1975308641975, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=481, Percent_Identity=24.5322245322245, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48851; Mature: 48720

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVIIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVIIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]