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The map label for this gene is lldD

Identifier: 218702374

GI number: 218702374

Start: 4298071

End: 4299261

Strand: Direct

Name: lldD

Synonym: ECIAI39_4126

Alternate gene names: 218702374

Gene position: 4298071-4299261 (Clockwise)

Preceding gene: 218702373

Following gene: 218702375

Centisome position: 83.75

GC content: 55.5

Gene sequence:

>1191_bases
ATGATTATTTCCGCAGCCAGCGATTATCGCGCCGCAGCACAACGCATTCTGCCGCCGTTCCTGTTCCACTATATGGATGG
GGGGGCATATTCTGAATACACGCTGCGCCGCAACGTGGAAGATTTGTCAGAAGTGGCGCTGCGCCAGCGTATTCTGAAAA
ACATGTCTGACTTAAGCCTGGAAACGACGCTGTTTAATGAGAAATTGTCGATGCCGGTGGCGCTAGGTCCGGTAGGTTTG
TGTGGCATGTATGCGCGACGCGGCGAAGTTCAGGCTGCCAAAGCCGCGGATGCGCATGGCATTCCGTTTACTCTCTCGAC
GGTTTCCGTTTGCCCGATTGAAGAAGTGGCTCCGGCTATCAAACGTCCGATGTGGTTCCAGCTTTATGTGCTGCGCGATC
GCGGCTTTATGCGTAACGCACTGGAGCGAGCAAAAGCAGCGGGTTGTTCGACACTGGTTTTCACCGTGGATATGCCAACA
CCGGGAGCGCGTTATCGTGATGCGCATTCTGGGATGAGCGGCCCGAACGCGGCAATGCGCCGCTATTTGCAGGCGGTGAC
GCATCCGCAATGGGCGTGGGATGTGGGCCTGAACGGTCGTCCGCATGATTTAGGTAATATCTCAGCTTATCTCGGCAAAC
CGACCGGACTGGAAGATTACATCGGCTGGCTGGGGAATAACTTCGATCCGTCCATCTCATGGAAAGACCTTGAGTGGATC
CGCGATTTCTGGGATGGCCCGATGGTGATCAAAGGGATCCTCGATCCGGAAGATGCGCGCGATGCAGTACGTTTTGGTGC
TGATGGGATTGTGGTTTCTAACCACGGTGGCCGCCAGCTGGACGGTGTACTCTCTTCCGCTCGTGCATTGCCCGCTATTG
CGGATGCGGTGAAAGGTGATATTGCCATTCTGGCAGATAGCGGGATTCGTAACGGGCTTGATGTCGTGCGTATGATTGCG
CTCGGTGCCGACACCGTACTGCTGGGTCGTGCTTTCCTGTATGCGCTGGCAACAGCGGGCCAGGCGGGTGTAGCTAACCT
GCTAAATCTGATCGAAAAAGAGATGAAAGTGGCGATGACGCTGACTGGCGCGAAATCGATTAGCGAAATTACGCAAGATT
CGCTGGTGCAAGGGCTGGGTAAAGAGTTGCCTGCGGCACTGGCTCCGATGGCGAAAGGGAATGCGGCATAG

Upstream 100 bases:

>100_bases
TTCACACCACCATGAAACGATTCGATGAAGATCAGGCTCGCCATGCACGCATTACCCGCCTGCCTGGTGACCATAATGAG
CATTCGAGGGAGAAAAACGC

Downstream 100 bases:

>100_bases
TTGGGGGTGAGGGGAAAAGGCCGTACCAATCACCAATTTTCTGCTATCCTGCCCCCGCACTAAGGGGGCAGTATGCTAAA
CATCGTACTTTACGAACCAG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALGPVGL
CGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA

Sequences:

>Translated_396_residues
MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALGPVGL
CGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA
>Mature_396_residues
MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALGPVGL
CGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=367, Percent_Identity=33.7874659400545, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI54234014, Length=378, Percent_Identity=34.1269841269841, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI7705393, Length=378, Percent_Identity=34.1269841269841, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1790033, Length=396, Percent_Identity=99.7474747474748, Blast_Score=805, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=34.2318059299191, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=32.0422535211268, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=29.0575916230367, Blast_Score=163, Evalue=4e-41,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=33.8624338624339, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=33.8624338624339, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=33.8624338624339, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42715; Mature: 42715

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSL
CEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNEKLSMPVALGPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHCCCEEECCHHHHHHHHHCCCCHHHHCCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSL
CEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNEKLSMPVALGPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHCCCEEECCHHHHHHHHHCCCCHHHHCCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA