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The map label for this gene is panF

Identifier: 218702031

GI number: 218702031

Start: 3922174

End: 3923625

Strand: Direct

Name: panF

Synonym: ECIAI39_3758

Alternate gene names: 218702031

Gene position: 3922174-3923625 (Clockwise)

Preceding gene: 218702030

Following gene: 218702032

Centisome position: 76.42

GC content: 54.48

Gene sequence:

>1452_bases
ATGCAGCTTGAAGTGATTCTACCGCTGGTCGCCTATCTGGTGGTGGTGTTCGGGATTTCAGTTTATGCAATGCGTAAACG
GAACACCGGCACCTTCCTCAATGAGTATTTCCTCGGCAGCCGTTCTATGGGCGGTATTGTGCTGGCGATGACGCTCACCG
CGACCTATATCAGTGCCAGTTCGTTTATCGGCGGGCCAGGAGCTGCTTATAAATACGGCCTGGGTTGGGTATTGCTGGCG
ATGATTCAGCTTCCTGCGGTTTGGCTTTCGCTCGGTATTCTCGGCAAAAAGTTCGCGATTCTTGCGCGCCGCTACAATGC
AGTGACGCTGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTGTGGCTGGCGAGTTTGAGTTTGCTGGTCG
CGTTTATTGGCGCGATGACCGTGCAGTTTATCGGCGGCGCGCGCCTGCTGGAAACCGCGGCGGGTATTCCTTATGAAACC
GGGCTGCTGATTTTCGGTATCAGCATTGCGTTGTATACCGCCTTTGGTGGCTTTCGCGCCAGCGTGCTGAACGACACCAT
GCAAGGGCTGGTGATGCTGATTGGCACCATTGTGCTGCTTATTGGCGTGGTCCATGCTGCTGGCGGCTTAAGCAATGCAG
TAGAGACGCTGCAAACCATCGATCCGCAACTGGTTACGCCACAAGGCGCTGACGATATTCTGTCACCTGCGTTTATGACG
TCGTTCTGGGTGCTGGTGTGCTTTGGCGTTATAGGCCTGCCGCATACTGCGGTGCGCTGTATCTCTTATAAAGACAGCAA
AGCAGTACATCGGGGGATCCTCATCGGTACGATTGTAGTCGCAATCCTGATGTTCGGTATGCATCTGGCCGGAGCGTTAG
GTCGGGCGGTGATCCCCGATCTCACCGTACCGGACCTGGTGATCCCGACGTTGATGGTAAAAGTACTGCCACCGTTTGCT
GCCGGGATCTTCCTTGCAGCTCCTATGGCTGCGATCATGTCGACGATCAACGCCCAATTGCTGCAAAGTTCCGCTACGAT
CATTAAAGATCTCTATCTGAATATCCGTCCGGATCAAATGCAAAACGAGACGCGCCTGAAGCGGATGTCGGCGGTGATTA
CGTTGATTCTCGGCGCGTTGCTGCTGCTTGCTGCATGGAAGCCGCCTGAAATGATCATCTGGCTGAATTTGCTGGCCTTC
GGCGGGCTGGAAGCTGTCTTCCTGTGGCCGCTGGTACTGGGTCTTTACTGGGAACGCGCTAACGCCAAAGGCGCGCTAAG
TGCGATGATCGTTGGCGGCGTGCTGTATGCCGTACTTGCGACACTGAATATTCAGTACCTGGGCTTCCACCCTATCGTGC
CCTCGTTGCTGCTAAGTTTGCTGGCTTTCCTGGTCGGAAACCGTTTCGGTACGTCCGTCCCGCAAGCTATCGTTTTGACT
ACTGATAAATAA

Upstream 100 bases:

>100_bases
TGGTTTGAGATGGCTTGCATCCTGACGCCGCTGCTGTTTATTGGACTGTGCTGGGCGATGGTGAAATTTATCTATCGCGA
TATCCCGTTGGAGGATGACG

Downstream 100 bases:

>100_bases
AGAGTTTTGCCATGCCTTGGATCCAACTGAAACTGAACACCACCGGCGCGAACGCCGAAGATCTTAGCGATGCGCTGATG
GAAGCGGGTGCCGTTTCTAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRNTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTIVLLIGVVHAAGGLSNAVETLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGILIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLILGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQAIVLT
TDK

Sequences:

>Translated_483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRNTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTIVLLIGVVHAAGGLSNAVETLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGILIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLILGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQAIVLT
TDK
>Mature_483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRNTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTIVLLIGVVHAAGGLSNAVETLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGILIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLILGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQAIVLT
TDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=27.4841437632135, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=24.0585774058577, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507033, Length=407, Percent_Identity=26.044226044226, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=24.8434237995825, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI110835708, Length=500, Percent_Identity=24.4, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4507035, Length=396, Percent_Identity=24.7474747474747, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157671931, Length=359, Percent_Identity=21.7270194986072, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=98.5507246376812, Blast_Score=945, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=483, Percent_Identity=26.9151138716356, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790113, Length=475, Percent_Identity=23.5789473684211, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790503, Length=492, Percent_Identity=22.1544715447154, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24651739, Length=438, Percent_Identity=21.0045662100457, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51800; Mature: 51800

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]