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The map label for this gene is kdsC

Identifier: 218701967

GI number: 218701967

Start: 3851892

End: 3852458

Strand: Direct

Name: kdsC

Synonym: ECIAI39_3693

Alternate gene names: 218701967

Gene position: 3851892-3852458 (Clockwise)

Preceding gene: 218701966

Following gene: 218701968

Centisome position: 75.06

GC content: 52.38

Gene sequence:

>567_bases
ATGAGCAAAGCAGGTGCGTCGCTTGCGACCTGTTACGGCCCTGTCAGCGCCGACGTTATAGCAAAAGCAGAGAACATTCG
TCTGCTGATCCTCGATGTCGATGGCGTACTGTCAGATGGCCTGATTTATATGGGCAATAATGGCGAAGAGCTGAAAGCGT
TCAATGTTCGTGACGGTTATGGCATTCGTTGTGCGCTCACCTCTGATATTGAAGTCGCTATCATTACCGGGCGAAAGGCT
AAACTGGTAGAAGATCGTTGTGCCACATTGGGGATCACTCACTTGTATCAGGGGCAGTCAAACAAACTGATCGCCTTTAG
CGATCTGCTGGAAAAACTGGCGATTGCCCCGGAAAATGTGGCTTATGTCGGCGATGATCTCATCGACTGGCCGGTAATGG
AAAAAGTGGGTTTAAGCGTCGCCGTGGCCGATGCGCATCCACTGTTGATCCCGCGCGCCGATTACGTGACGCGCATTGCT
GGCGGTCGTGGCGCAGTGCGAGAAGTTTGCGACTTATTACTCCTGGCGCAGGGCAAACTGGATGAAGCCAAAGGGCAATC
GATATGA

Upstream 100 bases:

>100_bases
CCTCCGTGATGGTTGCCGATGGCGACCATTTACTCGGTGTGTTACATATGCATGATTTACTGCGTGCAGGCGTAGTGTAA
AGATTCAAGGATAAACAACA

Downstream 100 bases:

>100_bases
GTAAAGCCAGACGTTGGGTTATCATTGTGCTATCACTGGCGGTTCTGGTGATGATCGGCATTAATATGGCCGAAAAAGAC
GATACCGCCCAGGTGGTCGT

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKA
KLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIA
GGRGAVREVCDLLLLAQGKLDEAKGQSI

Sequences:

>Translated_188_residues
MSKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKA
KLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIA
GGRGAVREVCDLLLLAQGKLDEAKGQSI
>Mature_187_residues
SKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKAK
LVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAG
GRGAVREVCDLLLLAQGKLDEAKGQSI

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family

Homologues:

Organism=Homo sapiens, GI8923900, Length=163, Percent_Identity=29.4478527607362, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI2367202, Length=188, Percent_Identity=100, Blast_Score=376, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSC_ECO57 (P0ABZ5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   E91138
- PIR:   H85983
- RefSeq:   NP_289772.1
- RefSeq:   NP_312104.1
- ProteinModelPortal:   P0ABZ5
- SMR:   P0ABZ5
- EnsemblBacteria:   EBESCT00000024323
- EnsemblBacteria:   EBESCT00000056436
- GeneID:   916077
- GeneID:   958043
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4561
- KEGG:   ecs:ECs4077
- GeneTree:   EBGT00050000009685
- HOGENOM:   HBG471796
- OMA:   KTFNTLD
- ProtClustDB:   PRK09484
- BioCyc:   ECOL83334:ECS4077-MONOMER
- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023
- Gene3D:   G3DSA:3.40.50.1000
- PIRSF:   PIRSF006118
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01670

Pfam domain/function: PF08282 Hydrolase_3; SSF56784 SSF56784

EC number: =3.1.3.45

Molecular weight: Translated: 19997; Mature: 19866

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGY
CCCCCCCEEEECCCCCHHEEEECCCCEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCC
GIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENV
EEEEEEECCCEEEEEECCCHHHHHHHHHHHCHHHEECCCCCCEEEHHHHHHHHHCCCCCE
AYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKL
EECCCCCCCCCHHHHCCCEEEEECCCCEEEECCHHHEEECCCCCHHHHHHHHHHHCCCCC
DEAKGQSI
CCCCCCCC
>Mature Secondary Structure 
SKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGY
CCCCCCEEEECCCCCHHEEEECCCCEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCC
GIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENV
EEEEEEECCCEEEEEECCCHHHHHHHHHHHCHHHEECCCCCCEEEHHHHHHHHHCCCCCE
AYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKL
EECCCCCCCCCHHHHCCCEEEEECCCCEEEECCHHHEEECCCCCHHHHHHHHHHHCCCCC
DEAKGQSI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796