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The map label for this gene is agaA

Identifier: 218701910

GI number: 218701910

Start: 3795620

End: 3796774

Strand: Direct

Name: agaA

Synonym: ECIAI39_3636

Alternate gene names: 218701910

Gene position: 3795620-3796774 (Clockwise)

Preceding gene: 218701909

Following gene: 218701911

Centisome position: 73.96

GC content: 58.27

Gene sequence:

>1155_bases
ATGTCCGGTCGAGGAAGGAATATGACACACGTTCTGCGCGCCAGAAGGCTGCTGACTGAAGAGGGATGGCTCGATGACCA
TCAGTTGCGTATTGCTGACGGTGTAATCGCAGCAATCGAACCGATTCCAGTGGGCGTGACTGAACGCGATGCGGAACTGC
TCTGCCCCGCTTACATCGACACCCATGTACACGGTGGTGCGGGCGTTGATGTAATGGATGACGCGCCGGATGCGCTCGAC
AAGCTGGCAATGCACAAGGCACGCGAAGGTGTCGGCAGTTGGTTACCGACCACCGTAACCGCGCCGCTTAATACCATTCA
TGCGGCGCTGAAACGTATTGCTCTACGCTGCCAGCGTGGCGGACCTGGTGCGCAAGTGCTGGGGAGTTATCTCGAAGGAC
CGTACTTCACGCCGCAGAATAAAGGCGCGCATCCGCCGGAGCTGTTTCGCGAGCTGGAAATTGCCGAGCTGGAGCAATTG
ATTGCCGTTTCTCAGCACACCTTGCGCGTGGTAGCGCTGGCACCAGAAAAAGAAGGGGCATTGCAGGCCATCCGCCATCT
TAAACAGCAAAACGTACGGGTGATGCTGGGGCATAGCGCGGCGACCTGGCAACAAACCCGTGCCGCGTTTGACGCTGGTG
CCGACGGCCTGGTGCATTGCTATAACGGGATGACAGGTTTACATCACCGCGAACCGGGAATGGTTGGCGCGGGATTAACG
GACAAGCGCGCCTGGCTGGAACTGATAGCCGATGGTCATCATGTACATCCGGCGGCGATGTCGCTGTGTTGTTGCTGTGC
GAAAGAGAGAATCGTGCTGATCACCGACGCGATGCAGGCAGCCGGGATGCCGGATGGTCGCTATACGTTATGTGGTGAAG
AAGTGCAGATGCACGATGGCGTTGTCCGTACCGCGTCCGGTGGGCTGGCGGGCAGTACGCTGTCTGTCGATGCGGCAGTG
CGCAACATGGTCGAGTTGACGGGCGTAACGCCTGCGGAAGCCATCCATATGGCATCGCTGCATCCGGCGCGTATGCTGGG
TGTTGATGGTGTTCTGGGATCGCTTAAACCGGGCAAACGCGCCAGCGTCGTTGCGCTGGATAGCGGGCTGCATGTGCAAC
AAATCTGGATTCAGGGTCAATTAGCTTCGTTTTGA

Upstream 100 bases:

>100_bases
GCGAAGGGTTAAGCGGTGAAGAGTTCCGTGTGCAGGCGCTGGAGTGTGGACACCGTGGGCTGACCAGTCTGGTGGACGAG
TTAGGCCGCTGCCATGAAGA

Downstream 100 bases:

>100_bases
TGGTTTGCTCCTTTATTGGGCCTTCACTTCCCCCGTAAGGCCTTTCTTTTTCTTTCTTTTTGATCTGTGCAGCGGTGTCG
GATGCGACGCTGACGCGTCT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: D-Galactosamine 6-Phosphate; Acetate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSGRGRNMTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVGVTERDAELLCPAYIDTHVHGGAGVDVMDDAPDALD
KLAMHKAREGVGSWLPTTVTAPLNTIHAALKRIALRCQRGGPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELEQL
IAVSQHTLRVVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLT
DKRAWLELIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHDGVVRTASGGLAGSTLSVDAAV
RNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQIWIQGQLASF

Sequences:

>Translated_384_residues
MSGRGRNMTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVGVTERDAELLCPAYIDTHVHGGAGVDVMDDAPDALD
KLAMHKAREGVGSWLPTTVTAPLNTIHAALKRIALRCQRGGPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELEQL
IAVSQHTLRVVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLT
DKRAWLELIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHDGVVRTASGGLAGSTLSVDAAV
RNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQIWIQGQLASF
>Mature_383_residues
SGRGRNMTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVGVTERDAELLCPAYIDTHVHGGAGVDVMDDAPDALDK
LAMHKAREGVGSWLPTTVTAPLNTIHAALKRIALRCQRGGPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELEQLI
AVSQHTLRVVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTD
KRAWLELIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHDGVVRTASGGLAGSTLSVDAAVR
NMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQIWIQGQLASF

Specific function: N-acetylgalactosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=416, Percent_Identity=33.4134615384615, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI224922791, Length=416, Percent_Identity=33.1730769230769, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1786892, Length=380, Percent_Identity=30.7894736842105, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17553768, Length=392, Percent_Identity=30.1020408163265, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19920392, Length=389, Percent_Identity=30.8483290488432, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI281361140, Length=402, Percent_Identity=29.8507462686567, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 41056; Mature: 40925

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRGRNMTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVGVTERDAELLCPAYID
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCCCCCCCCCHHCCHHHHH
THVHGGAGVDVMDDAPDALDKLAMHKAREGVGSWLPTTVTAPLNTIHAALKRIALRCQRG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELEQLIAVSQHTLRVVALAPEKEGA
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCCCHH
LQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLT
HHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCCCCCEECCCC
DKRAWLELIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHDG
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCEEEECCHHHHCCC
VVRTASGGLAGSTLSVDAAVRNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKR
EEEECCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCCCCC
ASVVALDSGLHVQQIWIQGQLASF
EEEEEECCCCEEEEEEEECCCCCC
>Mature Secondary Structure 
SGRGRNMTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVGVTERDAELLCPAYID
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCCCCCCCCCHHCCHHHHH
THVHGGAGVDVMDDAPDALDKLAMHKAREGVGSWLPTTVTAPLNTIHAALKRIALRCQRG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELEQLIAVSQHTLRVVALAPEKEGA
CCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCCCHH
LQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLT
HHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCCCCCEECCCC
DKRAWLELIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHDG
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCEEEECCHHHHCCC
VVRTASGGLAGSTLSVDAAVRNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKR
EEEECCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCCCCC
ASVVALDSGLHVQQIWIQGQLASF
EEEEEECCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Acetyl-D-Galactosamine 6-Phosphate; H2O [C]

Specific reaction: N-Acetyl-D-Galactosamine 6-Phosphate + H2O = D-Galactosamine 6-Phosphate + Acetate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8932697 [H]