Click here to switch to the map view.

The map label for this gene is ygfU

Identifier: 218701597

GI number: 218701597

Start: 3458473

End: 3459921

Strand: Direct

Name: ygfU

Synonym: ECIAI39_3303

Alternate gene names: 218701597

Gene position: 3458473-3459921 (Clockwise)

Preceding gene: 218701596

Following gene: 218701598

Centisome position: 67.39

GC content: 49.07

Gene sequence:

>1449_bases
ATGAGCGCCATAGATTCCCAACTTCCCTCATCTTCTGGGCAAGACCGCCCAACTGATGAGGTTGACCGCATATTATCACC
AGGAAAGCTGATCATACTCGGTCTGCAACACGTCCTTGTCATGTACGCAGGTGCAGTCGCTGTTCCTCTTATGATTGGCG
ACCGACTGGGCCTCTCAAAAGAAGCTATTGCGATGCTCATTAGCTCGGATCTCTTTTGCTGCGGGATCGTCACATTATTG
CAATGTATCGGTATCGGCCGCTTTATGGGGATCCGCCTGCCGGTGATTATGTCGGTGACCTTCGCCGCTGTAACACCAAT
GATAGCCATTGGGATGAACCCGGATATCGGCCTGCTGGGGATATTTGGTGCCACTATCGCCGCGGGTTTTATCACCACAT
TATTAGCGCCACTTATCGGTCGCTTGATGCCTTTATTCCCGCCACTGGTTACCGGTGTGGTGATTACTTCTATCGGGCTT
AGCATCATTCAGGTGGGTATTGACTGGGCCGCCGGAGGTAAAGGAAATCCGCAATATGGTAATCCCGTTTATTTAGGTAT
CTCCTTTGCTGTCTTAATTTTTATCTTGCTCATTACTCGCTATGCGAAAGGATTTATGTCCAACGTCGCCGTATTACTGG
GGATTGTATTTGGCTTTTTACTTTCGTGGATGATGAATGAAGTCAATTTATCCGGGCTACATGATGCTTCATGGTTTGCG
ATTGTCACGCCGATGTCATTTGGTATGCCGATTTTCGATCCCGTTTCCATTCTGACCATGACTGCCGTGTTAATCATCGT
GTTTATCGAGTCGATGGGGATGTTCCTGGCACTGGGTGAAATAGTCGGTCGTAAACTCTCTTCACACGATATTATTCGCG
GGCTGCGTGTCGATGGCGTAGGGACAATGATAGGCGGAACGTTTAACAGCTTCCCCCACACGTCATTTTCACAAAACGTT
GGCCTGGTTAGCGTGACGCGCGTTCATAGCCGCTGGGTGTGTATTTCTTCGGGAATTATATTAATCCTGTTTGGCATAGT
GCCAAAAATGGCGGTGCTGGTCGCCTCCATTCCGCAATTTGTGCTGGGCGGTGCTGGGCTGGTGATGTTCGGCATGGTAC
TGGCGACAGGGATTCGAATTCTGTCGCGCTGTAACTACACCACCAACCGTTACAACCTCTATATTGTGGCGATCAGTCTC
GGCGTTGGCATGACTCCGACGCTCTCTCACGATTTCTTTTCTAAGTTACCGGCCGTACTGCAACCGTTGCTGCATAGCGG
CATTATGCTCGCAACCCTTAGCGCCGTTGTGCTGAACGTCTTCTTTAATGGCTATCAGCATCATGCTGATCTGGTGAAGG
AATCCGTCTCTGATAAAGATTTAAAAGTCAGGACAGTACGTATGTGGCTTCTGATGCGCAAGCTGAAGAAAAATGAGCAT
GGAGAATAA

Upstream 100 bases:

>100_bases
CCTTCCTCGCAAAAACTGGCACTCCACGAGCATGTATTTAGACAGTTTCATGAACGTAAACGGTTGCTTTTTACTCTGGC
GGGCGAAAGGAGAAACACTG

Downstream 100 bases:

>100_bases
TATGAATCTTTTAATGCGCGCTATATTCAGTCTGTTGTTGCTTTTTACTCTCTCTATTCCTGTCATTTCTGACTGTGTTG
CAATGGCCATTGAAAGTCGC

Product: transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLL
QCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGL
SIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNV
GLVSVTRVHSRWVCISSGIILILFGIVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISL
GVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
GE

Sequences:

>Translated_482_residues
MSAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLL
QCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGL
SIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNV
GLVSVTRVHSRWVCISSGIILILFGIVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISL
GVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
GE
>Mature_481_residues
SAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQ
CIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLS
IIQVGIDWAAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAI
VTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVG
LVSVTRVHSRWVCISSGIILILFGIVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISLG
VGMTPTLSHDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEHG
E

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=444, Percent_Identity=24.7747747747748, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI40316845, Length=444, Percent_Identity=24.7747747747748, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=25.858123569794, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI44680143, Length=441, Percent_Identity=25.6235827664399, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI87082181, Length=482, Percent_Identity=99.7925311203319, Blast_Score=956, Evalue=0.0,
Organism=Escherichia coli, GI1790087, Length=460, Percent_Identity=28.695652173913, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI87082178, Length=465, Percent_Identity=26.4516129032258, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788843, Length=391, Percent_Identity=27.6214833759591, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081818, Length=457, Percent_Identity=25.8205689277899, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17558856, Length=472, Percent_Identity=23.5169491525424, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17541904, Length=463, Percent_Identity=21.1663066954644, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17542260, Length=238, Percent_Identity=27.7310924369748, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=450, Percent_Identity=22.8888888888889, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356175, Length=427, Percent_Identity=24.1217798594848, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 51741; Mature: 51610

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSK
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EAIAMLISSDLFCCGIVTLLQCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLG
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHH
IFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGV
EECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEECCC
GTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGIVPKMAVLVASIPQF
HHHHCCCCCCCCCCCCCCCCCEEEEEHHHHCEEEHHCCHHHHHHHHHHHHHHHHHHHHHH
VLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVL
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
QPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
GE
CC
>Mature Secondary Structure 
SAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSK
CCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EAIAMLISSDLFCCGIVTLLQCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLG
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHH
IFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGV
EECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEECCC
GTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGIVPKMAVLVASIPQF
HHHHCCCCCCCCCCCCCCCCCEEEEEHHHHCEEEHHCCHHHHHHHHHHHHHHHHHHHHHH
VLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVL
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
QPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
GE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]