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The map label for this gene is dsdC

Identifier: 218700832

GI number: 218700832

Start: 2598484

End: 2599437

Strand: Reverse

Name: dsdC

Synonym: ECIAI39_2507

Alternate gene names: 218700832

Gene position: 2599437-2598484 (Counterclockwise)

Preceding gene: 218700835

Following gene: 218700830

Centisome position: 50.65

GC content: 47.17

Gene sequence:

>954_bases
GTGATTATGGAACCCCTTCGTGAAATAAGAAATCGACTGCTTAACGGCTGGCAACTATCAAAACTGCATACTTTTGAAGT
GGCAGCCAGGCATCAGTCCTTCGCCCTTGCGGCAGAGGAATTGTCGCTGAGCCCCAGTGCGGTAAGTCACCGTATCAATC
AGCTGGAAGAAGAATTAGGTATTCAGTTGTTTGTTCGTTCCCATCGCAAAGTGGAATTAACGCACGAGGGGAAACGCGTT
TATTGGGCGCTAAAATCGTCGCTGGATACCCTGAACCAGGAAATTCTTGATATCAAAAATCAGGAATTATCGGGAACGTT
AACGCTGTATTCCCGGCCCTCTATCGCCCAATGCTGGTTGGTGCCCGCATTAGGTGACTTTACACGCCGCTATCCGTCTA
TTTCGCTCACCGTGCTTACTGGTAATGACAATGTCAATTTGCAACGTGCCGGAATCGATTTGGCAATCTACTTTGATGAC
GCGCCGTCAGCGCAATTGACTCATCACTTTCTGATGGATGAAGAAATCCTGCCTGTATGTAGCCCGGAATACGCTCAAAG
ACATGCTTTAACCAACCAGGTAATTAACCTGCGCCACTGTACGTTGCTCCATGACAGACAGGCATGGAGCAACGACTCCG
GTACGGATGAATGGCATAGTTGGGCGCAACATTATGCGGTTAATTTGCCGACATCTTCTGGGATTGGCTTTGATCGTTCT
GATTTAGCTGTTATCGCTGCGATGAATCATATTGGGGTAGCGATGGGAAGAAAACGCCTGGTACAAAAAAGGCTTGCCAG
TGGTGAGCTCGTCGCGCCGTTTGGCGATATGACGGTGAAATGCCATCAGCATTATTACATCACCACATTACCGGGCAGGC
AGTGGCCAAAAATTGAGGCATTTATTACTTGGTTAAGAGAACAGGTAAGTCAATATGAATGTTATACCTTATAA

Upstream 100 bases:

>100_bases
TTACATCTAAAAATGAAGGTGAATTGAGATATGGTTCACTTTAGCTCACCTTACAGCTGAAATTTTGCCGCTATTTTTTT
ACACTTAAGAGAAAAATGAG

Downstream 100 bases:

>100_bases
TACATTAAATCATCTGGTTCCTAAATAACCTTATTATGCACTGTAAGTGTATGTTGGCTTTATAAATTGCAATTTTTATA
TGGGAATTGTTTTGTCAATA

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MIMEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRV
YWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDD
APSAQLTHHFLMDEEILPVCSPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRS
DLAVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVSQYECYTL

Sequences:

>Translated_317_residues
MIMEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRV
YWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDD
APSAQLTHHFLMDEEILPVCSPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRS
DLAVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVSQYECYTL
>Mature_317_residues
MIMEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRV
YWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDD
APSAQLTHHFLMDEEILPVCSPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRS
DLAVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVSQYECYTL

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=307, Percent_Identity=98.6970684039088, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1786448, Length=302, Percent_Identity=33.4437086092715, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=31.25, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786401, Length=296, Percent_Identity=25.6756756756757, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787128, Length=295, Percent_Identity=27.1186440677966, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87081978, Length=193, Percent_Identity=31.0880829015544, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693105, Length=168, Percent_Identity=27.3809523809524, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI145693193, Length=176, Percent_Identity=30.6818181818182, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788748, Length=169, Percent_Identity=28.4023668639053, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789440, Length=268, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787589, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790208, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI157672245, Length=172, Percent_Identity=33.1395348837209, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082132, Length=284, Percent_Identity=25.3521126760563, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787806, Length=176, Percent_Identity=28.4090909090909, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789639, Length=141, Percent_Identity=29.0780141843972, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36198; Mature: 36198

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELG
CCCHHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHC
IQLFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWL
EEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEE
VPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLTHHFLMDEEILPVC
EHHHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCC
SPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRS
CHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCC
DLAVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEA
CCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHH
FITWLREQVSQYECYTL
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIMEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELG
CCCHHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHC
IQLFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWL
EEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEE
VPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLTHHFLMDEEILPVC
EHHHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCC
SPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRS
CHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCC
DLAVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEA
CCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHH
FITWLREQVSQYECYTL
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]