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The map label for this gene is dmsC

Identifier: 218700586

GI number: 218700586

Start: 2310728

End: 2311591

Strand: Reverse

Name: dmsC

Synonym: ECIAI39_2252

Alternate gene names: 218700586

Gene position: 2311591-2310728 (Counterclockwise)

Preceding gene: 218700587

Following gene: 218700584

Centisome position: 45.04

GC content: 54.28

Gene sequence:

>864_bases
ATGGGAAGTGGATGGCATGAATGGCCGCTGATGATCTTCACGGTCTTCGGGCAATGTGTAGCGGGTGGTTTTATCGTTCT
GGCTTTGGCGCTGCTCAAAGGCGACCTGCGAGCAGAAGCCCAGCAGCGTGTTATTGCCTGCATGTTTGGTTTATGGGTGC
TGATGGGCATTGGCTTTATCGCCTCTATGCTTCATCTTGGTTCACCGATGCGCGCCTTTAACTCGCTCAACCGGGTAGGG
GCTTCAGCACTCAGTAACGAAATCGCCAGCGGTTCGATCTTTTTTGCTGTTGGTGGCATCGGCTGGTTGCTGGCAATGCT
GAAAAAGCTGTCACCGGCATTGCGTACGCTGTGGCTGATAGTGACGATGGTTCTTGGCGTCATCTTTGTCTGGATGATGG
TGCGTGTGTATAACAGCATTGATACCGTTCCGACCTGGTACAGCATCTGGACGCCGATGGGCTTCTTCCTGACGATGTTT
ATGGGCGGCCCGTTACTGGGTTACCTGTTGTTGAGTCTGGCTGGCGTCGATGGCTGGGCGATGCGTCTGCTGCCAGCAAT
TTCTGTACTGGCACTGGTAGTGAGTGGCGTGATGTCAGTGATGCAGGGCGCAGAGCTGGCGACTATTCATAGTTCTGTGC
AGCAGGCCGCAGCGCTGGTGCCGGACTATGGTGCGCTGATGTCCTGGCGGATCGTGCTTTTGGCTGTTGCCCTGTGCTTG
TGGATTGCACCACAGCTAAAAGGTTATCAGCCTGCGGTTCCGCTACTTTCCGTATCATTCATTCTGCTTCTGGCAGGGGA
ATTAATCGGTCGTGGCGTATTCTATGGTTTGCATATGACCGTGGGGATGGCCGTCGCAAGCTAA

Upstream 100 bases:

>100_bases
GCTCACTTTACCAAACCGAATATTGTGATCAAACCCAATGCCAACAGCCGCCCGACCGGGGATACCACTGGCTATCTGGC
AAACCCGAAGGAGGTGTGAG

Downstream 100 bases:

>100_bases
TCATAACAACCGGGGTTTCGGCCCCGGTTCTCTTTTATTTCTGCTTCGTTAACGTGTCATAACTGGTCATCAAATTACGA
TAATCAGGAATATGGTTAGA

Product: dimethyl sulfoxide reductase subunit C

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase anchor subunit [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVG
ASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMF
MGGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVMSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS

Sequences:

>Translated_287_residues
MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVG
ASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMF
MGGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVMSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS
>Mature_286_residues
GSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVGA
SALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFM
GGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVMSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCLW
IAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the dmsAB dimer to the membrane and stabilizes it [H]

COG id: COG3302

COG function: function code R; DMSO reductase anchor subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli ynfH [H]

Homologues:

Organism=Escherichia coli, GI1787123, Length=287, Percent_Identity=99.6515679442509, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1787873, Length=286, Percent_Identity=56.6433566433566, Blast_Score=287, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007059 [H]

Pfam domain/function: PF04976 DmsC [H]

EC number: NA

Molecular weight: Translated: 30859; Mature: 30728

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGGPLLGYLLLSLAGVDGWA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
MRLLPAISVLALVVSGVMSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 8429002; 2170332 [H]