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The map label for this gene is uidB

Identifier: 218699818

GI number: 218699818

Start: 1514422

End: 1515795

Strand: Direct

Name: uidB

Synonym: ECIAI39_1442

Alternate gene names: 218699818

Gene position: 1514422-1515795 (Clockwise)

Preceding gene: 218699817

Following gene: 218699819

Centisome position: 29.51

GC content: 52.11

Gene sequence:

>1374_bases
ATGAATCAACAACTCTCCTGGCGCACCATCGTCGGCTACAGCCTCGGTGACGTCGCCAATAACTTCGCCTTCGCAATGGG
GGCGCTCTTCCTGTTGAGTTACTACACCGACGTCGCTGGCGTCGGTGCCGCTGCGGCGGGCACCATGCTGTTACTGGTGC
GGGTATTCGATGCCTTCGCCGATGTCTTTGCCGGACGAGTGGTGGACAGTGTGAATACCCGATGGGGGAAATTCCGCCCG
TTTTTACTCTTCGGTACTGCGCCGTTAATGATCTTCAGCGTGCTGGTATTCTGGGTGCCGACCGACTGGAGCCATAGCAG
CAAAGTTGTGTATGCATATTTGACCTACATGGGACTCGGGCTTTGCTACAGCCTGGTGAATATTCCTTATGGTTCACTTG
CTACCGCGATGACCCAACAACCACAATCCCGCGCCCGTCTGGGCGCGGCTCGCGGGATTGCCGCGTCATTGACCTTTGTC
TGCCTGGCATTTCTGATAGGACCGAGCATTAAGAACTCCAGCCCGGAAGAGATGGTGTCGGTATACCATTTCTGGACGAT
TGTGCTGGCGATTGCCGGAATGGTGCTTTACTTCATCTGCTTCAAATCGACGCGTGAGAATGTGGTACGTATCGTGGCGC
AGCCGTCATTGAAGATCAGTCTGCAAACCCTGAAACGGAATCGCCCGCTGTTTATGTTGTGCATCGGTGCGCTGTGTGTG
CTGATTTCGACCTTCGCGGTCAGCGCCTCGTCGTTGTTCTACGTGCGCTATGTGTTAAATGATACCGGGCTGTTCACTGT
GCTGGTACTGGTGCAAAACCTGGTCGGTACTGTGGCATCGGCACCGCTGGTGCCGGGGATGGTCGCGAGGATCGGTAAAA
AGAATACCTTCCTGATTGGCGCTTTGCTGGGAACCTGCGGTTATCTGCTGTTCTTCTGGGTTTCGGTCTGGTCACTGCCG
GTGGCGTTGGTTGCGTTGGCCATCGCATCAATTGGCCAGGGCGTTACCATGACCGTGATGTGGGCACTGGAAGCTGATAC
CGTAGAATACGGTGAATACCTGACCGGCGTGCGAATTGAAGGGCTCACCTATTCACTATTCTCATTTACCCGTAAATGCG
GTCAGGCAATCGGAGGTTCAATTCCTGCCTTTATTTTGGGATTAAGCGGATATATCGCCAATCAGGCGCAAACGCCGGAA
GTTATTATGGGCATCCGCACATCAATTGCCTTAGTACCTTGCGGATTTATGCTACTAGCATTCGTCATTATCTGGTTTTA
TCCGCTCACGGATAAAAAATTCAAAGAAATCGTTGTTGAAATTGATAATCGTAAAAAAGTGCAGCAGCAATTAATCAACG
ATATCACTAGTTAA

Upstream 100 bases:

>100_bases
TCTTCACCCGCGACCGCAAACCGAAGTCGGCGGCTTTTCTGCTGCAAAAACGCTGGACTGGCATGAACTTCGGTGAAAAA
CCGCAGCAGGGAGGCAAACA

Downstream 100 bases:

>100_bases
TATTCAATAAAAATAATCAGAACATCAAAGGTGCAACTATGAGAAAAATAGTGGCCATGGCCGTTATTTGCCTGACGGCT
GCCTCTGGCCTTACCTCTGC

Product: glucuronide transporter

Products: Proton [Cytoplasm]; Glucuronides [Cytoplasm] [C]

Alternate protein names: Glucuronide permease [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRP
FLLFGTAPLMIFSVLVFWVPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV
CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLP
VALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQAQTPE
VIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQQQLINDITS

Sequences:

>Translated_457_residues
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRP
FLLFGTAPLMIFSVLVFWVPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV
CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLP
VALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQAQTPE
VIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQQQLINDITS
>Mature_457_residues
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRP
FLLFGTAPLMIFSVLVFWVPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFV
CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLP
VALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQAQTPE
VIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQQQLINDITS

Specific function: Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by uidC (gusC, AC Q47706) [H]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Escherichia coli, GI1787902, Length=457, Percent_Identity=98.6870897155361, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI145693206, Length=453, Percent_Identity=33.3333333333333, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI48994989, Length=457, Percent_Identity=32.8227571115974, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1786466, Length=460, Percent_Identity=30.8695652173913, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI87082306, Length=460, Percent_Identity=28.2608695652174, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1790561, Length=461, Percent_Identity=27.3318872017354, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49909; Mature: 49909

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00527 RIBOSOMAL_S14 ; PS00872 NA_GALACTOSIDE_SYMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; Glucuronides [Periplasm] [C]

Specific reaction: Proton [Periplasm] + Glucuronides [Periplasm] = Proton [Cytoplasm] + Glucuronides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3534890 [H]