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The map label for this gene is uidR

Identifier: 218699816

GI number: 218699816

Start: 1511632

End: 1512222

Strand: Direct

Name: uidR

Synonym: ECIAI39_1440

Alternate gene names: 218699816

Gene position: 1511632-1512222 (Clockwise)

Preceding gene: 218699815

Following gene: 218699817

Centisome position: 29.45

GC content: 50.76

Gene sequence:

>591_bases
ATGATGGATAACATGCAGACTGAAGCACAACCGACACGGACCCGGATCCTCAATGCTGCCAGAGAGATTTTTTCAGAAAA
TGGATTTCACAGTGCCTCGATGAAAGCCATCTGTAAATCTTGCGCCATTAGTCCCGGGACGCTCTATCACCATTTCATCT
CCAAAGAAGCCCTGATTCAGGCGATTATCTTACAGGACCAGGAGAGGGCGCTGGCCCGTTTCCGGGAACCGATTGAAGGG
ATTCATTTCGTTGACTATATGGTCGAGTCTATTGTCTCTCTCACCCATGAAGCCTTTGGGCAACGGGCGCTGGTGGTCGA
AATTATGGCGGAAGGGATGCGTAACCCACAGGTCGCCGCCATGCTTAAAAATAAGCATATGACGATCACGGAATTTGTTG
CCCAGCGGATGCGTGATGCCCAGCAAAAAGGCGAGATAAGCCCAGATATCAACACGGCAATGACTTCACGTTTACTGCTG
GATCTGACCTACGGTGTACTGGCCGATATCGAAGCGGAAGATCTGGCGCGTGAAGCGTCGTTTGCTCAGGGATTACGCGC
GATGATTGGCGGTATATTAACCGCATCCTGA

Upstream 100 bases:

>100_bases
GTATACGAATAGAGTGTGCCTTCGCACTATTCAACAGCAATGATAGGCGCTCACCTGACAACGCGGTAAACTAGTTATTC
ACGCTAACTATAATGGTTTT

Downstream 100 bases:

>100_bases
TCCTCTCTCTCTTTCCGCGGGCTGGTGACAACTGAGCCCACGTTTCATATCGTAATTTCTCTGTGCAAAAATCATCCTCC
CCGGGTTCGGAGAATCCCCC

Product: DNA-binding transcriptional repressor

Products: NA

Alternate protein names: Uid operon repressor

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MMDNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQAIILQDQERALARFREPIEG
IHFVDYMVESIVSLTHEAFGQRALVVEIMAEGMRNPQVAAMLKNKHMTITEFVAQRMRDAQQKGEISPDINTAMTSRLLL
DLTYGVLADIEAEDLAREASFAQGLRAMIGGILTAS

Sequences:

>Translated_196_residues
MMDNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQAIILQDQERALARFREPIEG
IHFVDYMVESIVSLTHEAFGQRALVVEIMAEGMRNPQVAAMLKNKHMTITEFVAQRMRDAQQKGEISPDINTAMTSRLLL
DLTYGVLADIEAEDLAREASFAQGLRAMIGGILTAS
>Mature_196_residues
MMDNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQAIILQDQERALARFREPIEG
IHFVDYMVESIVSLTHEAFGQRALVVEIMAEGMRNPQVAAMLKNKHMTITEFVAQRMRDAQQKGEISPDINTAMTSRLLL
DLTYGVLADIEAEDLAREASFAQGLRAMIGGILTAS

Specific function: Repressor for the uidRABC (gusRABC) operon

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787904, Length=196, Percent_Identity=100, Blast_Score=404, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UIDR_ECO57 (P0ACT8)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C85768
- PIR:   F90919
- RefSeq:   NP_288054.1
- RefSeq:   NP_310353.1
- ProteinModelPortal:   P0ACT8
- SMR:   P0ACT8
- EnsemblBacteria:   EBESCT00000026936
- EnsemblBacteria:   EBESCT00000060089
- GeneID:   913631
- GeneID:   961568
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z2623
- KEGG:   ecs:ECs2326
- GeneTree:   EBGT00050000008758
- HOGENOM:   HBG467801
- OMA:   TADCEAL
- ProtClustDB:   CLSK880148
- BioCyc:   ECOL83334:ECS2326-MONOMER
- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.357.10
- PRINTS:   PR00455

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like; SSF48498 TetR_like_C

EC number: NA

Molecular weight: Translated: 21800; Mature: 21800

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQ
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AIILQDQERALARFREPIEGIHFVDYMVESIVSLTHEAFGQRALVVEIMAEGMRNPQVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
MLKNKHMTITEFVAQRMRDAQQKGEISPDINTAMTSRLLLDLTYGVLADIEAEDLAREAS
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FAQGLRAMIGGILTAS
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMDNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQ
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AIILQDQERALARFREPIEGIHFVDYMVESIVSLTHEAFGQRALVVEIMAEGMRNPQVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
MLKNKHMTITEFVAQRMRDAQQKGEISPDINTAMTSRLLLDLTYGVLADIEAEDLAREAS
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FAQGLRAMIGGILTAS
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796