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The map label for this gene is ptrB

Identifier: 218699584

GI number: 218699584

Start: 1274904

End: 1276964

Strand: Direct

Name: ptrB

Synonym: ECIAI39_1205

Alternate gene names: 218699584

Gene position: 1274904-1276964 (Clockwise)

Preceding gene: 218699583

Following gene: 218699588

Centisome position: 24.84

GC content: 49.98

Gene sequence:

>2061_bases
ATGCTACCAAAAGCCGCCCGCATTCCCCACGCCATGACGCTTCATGGCGATACGCGCATCGATAATTACTACTGGCTGCG
GGACGATACGCGTTCTCAGCCGGAAGTCCTGGACTACCTGCAGCAAGAAAATAGTTACGGTCATCGGGTGATGGCCTCGC
AACAAGCCTTGCAGGATCGCATCTTAAAGGAAATCATCGACCGCATTCCGCAAAGAGAAGTTTCTGCGCCCTACATCAAA
AATGGCTACCGCTATCGGCATATTTATGAACCAGGCTGTGAATATGCTATCTACCAGCGTCAATCGGCGTTCAGTGAAGA
GTGGGACGAGTGGGAAACATTGCTCGATGCCAACAAGCGCGCGGCTCATAGTGAGTTTTATTCGATGGGCGGAATGGCGA
TTACGCCAGATAACACCATTATGGCACTGGCAGAAGATTTTCTTTCCCGACGCCAGTACGGCATTCGTTTTCGTAATCTG
GAAACAGGTAACTGGTACCCGGAACTGCTGGATAACGTTGAACCCAGCTTTGTCTGGGCAAATGACTCCTGGACTTTCTA
CTATGTTCGCAAGCATCCGGTGACGCTGCTGCCTTATCAGGTCTGGCGTCACGCCATCGGTACGCCAGCATCGCAGGATA
AACTGATCTACGAAGAAAAAGACGATACCTATTACGTCAGCCTGCATAAAACGACCTCGAAGCACTATGTAGTCATTCAT
CTGGCCAGCGCCACCACCAGTGAAGTTCGCCTGCTGGACGCGGAAATGGCCGATGCCGAGCCGTTTGTTTTTCTGCCTCG
CCGCAAAGATCACGAATACAGCCTTGATCACTACCAGCATCGGTTTTATCTGCGTTCCAACCGCCACGGTAAAAACTTTG
GCTTATACCATACCCGTATGCGTGATGAGCAACAGTGGGAAGAGTTAATTCCGCCACGTGATAACATTATGCTGGAAGGG
TTTACGCTGTTTACCGACTGGCTGGTGGTTGAAGAGCGTCAGCGCGGGTTAACCAGTTTGCGGCAAATTAACCGCAAGTC
CCGGGAAGTCATTGGCATTGCCTTTGATGATCCGGCCTATGTGACCTGGATTGCCTACAATCCAGAACCTGAAACCGCGC
GATTGCGTTATGGTTATTCTTCCATGACCACACCAGATACTTTGTTTGAACTGGATATGGATACCGGTGAGCGTCGTGTA
TTAAAACAAACGGAAGTGCCCGGTTTTGATGCGGCGAATTACCGCAGTGAACACCTGTGGATAGTCGCCCGTGATGGCGT
CGAAGTTCCGGTTTCGCTGGTCTATCATCGCAAACATTTTCGCAAAGGACACAACCCGCTGCTGGTGTATGGCTACGGTT
CTTACGGCGCAAGTATTGATGCCGATTTCAGTTTTAGCCGCTTGAGTTTGTTGGATCGTGGATTTGTCTACGCCATTGTC
CATGTTCGTGGCGGCGGTGAACTGGGGCAACAATGGTACGAAGACGGTAAGTTTCTGAAGAAGAAAAATACGTTTAATGA
TTATCTTGATGCCTGCGATGCATTGTTAAAGCTGGGCTATGGCTCTCCTTCGCTTTGTTATGCGATGGGCGGGAGTGCGG
GGGGCATGTTGATGGGCGTTGCAATTAATCAACGCCCGGAATTATTCCATGGCGTTATCGCCCAGGTACCGTTTGTTGAT
GTTGTAACAACGATGCTTGATGAATCAATTCCTCTTACCACTGGTGAGTTTGAAGAGTGGGGGAATCAGCAGGATCCGCA
ATATTACGAGTACATGAAAAGCTACAGCCCGTATGACAACGTCACCGCACAGGCTTATCCGCATTTACTGGTAACGACCG
GTTTACACGATTCTCAGGTGCAATATTGGGAACCGGCAAAATGGGTGGCTAAATTGCGCGAGCTGAAAACCGATAACCAT
CTTTTATTGCTCTGTACCGACATGGACTCAGGCCATGGCGGTAAATCTGGTCGCTTTAAATCGTACGAAGGTGTAGCGAT
GGAATATGCTTTTCTGGTCGCGCTGGCGCAGGGAACATTACCCGCTACGCCTGAGGATTAA

Upstream 100 bases:

>100_bases
ATTACCTGTCATCATCTAAGCAATGACTACCCTGTTTCGCTTGCATCCCCGGTGAGTTTTGCCACCCTTATAAGATGTTT
CAACCAGAAAGAACAATAAC

Downstream 100 bases:

>100_bases
GTATTTTCCAGATAATGTTTCAGTGTTAAACGCAGCTCCGGGCTCATGCTGTCCAGGTTATTAAATAACCAGCGCAGATA
GCCCGGATCGCGTTCGGCTA

Product: protease 2

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIK
NGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNL
ETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYHTRMRDEQQWEELIPPRDNIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKSREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVPFVD
VVTTMLDESIPLTTGEFEEWGNQQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDNH
LLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPED

Sequences:

>Translated_686_residues
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIK
NGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNL
ETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYHTRMRDEQQWEELIPPRDNIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKSREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVPFVD
VVTTMLDESIPLTTGEFEEWGNQQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDNH
LLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPED
>Mature_686_residues
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIK
NGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNL
ETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYHTRMRDEQQWEELIPPRDNIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKSREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVPFVD
VVTTMLDESIPLTTGEFEEWGNQQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDNH
LLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPED

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=696, Percent_Identity=24.7126436781609, Blast_Score=197, Evalue=4e-50,
Organism=Homo sapiens, GI284172420, Length=474, Percent_Identity=29.535864978903, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI284172413, Length=474, Percent_Identity=29.535864978903, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI70778815, Length=474, Percent_Identity=29.535864978903, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI284172438, Length=474, Percent_Identity=29.535864978903, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI284172431, Length=474, Percent_Identity=29.535864978903, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI108860686, Length=214, Percent_Identity=40.1869158878505, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI108860692, Length=213, Percent_Identity=40.3755868544601, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1788150, Length=686, Percent_Identity=98.8338192419825, Blast_Score=1414, Evalue=0.0,
Organism=Drosophila melanogaster, GI24583414, Length=701, Percent_Identity=23.1098430813124, Blast_Score=163, Evalue=5e-40,
Organism=Drosophila melanogaster, GI221510989, Length=704, Percent_Identity=25.1420454545455, Blast_Score=149, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 79472; Mature: 79472

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDR
CCCCCCCCCEEEEECCCCEECCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
ILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKR
HHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCH
AAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNLETGNWYPELLDNVEPSFVWA
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHCCCCCCEEEE
NDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
CCCEEEEEEECCCCEEECHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCCEEEEE
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYHTRM
EECCCCCCEEEEEHHCCCCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCCCEEEHHC
RDEQQWEELIPPRDNIMLEGFTLFTDWLVVEERQRGLTSLRQINRKSREVIGIAFDDPAY
CCHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCE
VTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRVLKQTEVPGFDAANYRSEHLW
EEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
IVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
EEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGV
EEECCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
AINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNQQDPQYYEYMKSYSPYDN
EECCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCC
VTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDNHLLLLCTDMDSGHGGKSGRFK
CCHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
SYEGVAMEYAFLVALAQGTLPATPED
CCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDR
CCCCCCCCCEEEEECCCCEECCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
ILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKR
HHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCH
AAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNLETGNWYPELLDNVEPSFVWA
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHCCCCCCEEEE
NDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
CCCEEEEEEECCCCEEECHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCCEEEEE
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYHTRM
EECCCCCCEEEEEHHCCCCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCCCEEEHHC
RDEQQWEELIPPRDNIMLEGFTLFTDWLVVEERQRGLTSLRQINRKSREVIGIAFDDPAY
CCHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCE
VTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRVLKQTEVPGFDAANYRSEHLW
EEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
IVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
EEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGV
EEECCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
AINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNQQDPQYYEYMKSYSPYDN
EECCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCC
VTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDNHLLLLCTDMDSGHGGKSGRFK
CCHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
SYEGVAMEYAFLVALAQGTLPATPED
CCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]