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The map label for this gene is uvrY

Identifier: 218699522

GI number: 218699522

Start: 1211530

End: 1212186

Strand: Direct

Name: uvrY

Synonym: ECIAI39_1141

Alternate gene names: 218699522

Gene position: 1211530-1212186 (Clockwise)

Preceding gene: 218699520

Following gene: 218699523

Centisome position: 23.61

GC content: 49.77

Gene sequence:

>657_bases
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTTGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGCCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTTAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTTGTGAGTGCGATCCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Upstream 100 bases:

>100_bases
AATACCCACCATTTTTAACGTTTCAAAGTTGCAATAAAAACCGCTAATATACGAATGACTAACTATCAGTAGCGTTATCC
CTATTTCTGGAGATATTCCT

Downstream 100 bases:

>100_bases
GTGATCAGTTTGACGCAAAAGCGTTTTTAAAAACCGTAACCAGCCAGCCAGGCGTTTATCGCATGTACGATGCTGGTGGT
ACGGTTATCTATGTCGGCAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Sequences:

>Translated_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
>Mature_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=99.5412844036697, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=36.5, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=32.0388349514563, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=27.3170731707317, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=27.0531400966184, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788546, Length=207, Percent_Identity=26.5700483091787, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRY_ECO57 (P66798)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D90960
- PIR:   E85808
- RefSeq:   NP_288375.1
- RefSeq:   NP_310679.1
- ProteinModelPortal:   P66798
- SMR:   P66798
- EnsemblBacteria:   EBESCT00000028251
- EnsemblBacteria:   EBESCT00000059111
- GeneID:   912605
- GeneID:   961912
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3002
- KEGG:   ecs:ECs2652
- GeneTree:   EBGT00050000008645
- HOGENOM:   HBG753323
- OMA:   MVNAIRV
- ProtClustDB:   PRK09483
- BioCyc:   ECOL83334:ECS2652-MONOMER
- GO:   GO:0005737
- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00038
- SMART:   SM00421
- SMART:   SM00448

Pfam domain/function: PF00196 GerE; PF00072 Response_reg; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 23863; Mature: 23863

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00622 HTH_LUXR_1; PS50043 HTH_LUXR_2; PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796