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The map label for this gene is cbl

Identifier: 218699446

GI number: 218699446

Start: 1120315

End: 1121265

Strand: Direct

Name: cbl

Synonym: ECIAI39_1060

Alternate gene names: 218699446

Gene position: 1120315-1121265 (Clockwise)

Preceding gene: 218699445

Following gene: 218699447

Centisome position: 21.83

GC content: 48.26

Gene sequence:

>951_bases
GTGAATTTCCAACAACTAAAGATAATCCGCGAGGCTGCACGTCAGGATTACAACCTGACAGAGGTTGCGAATATGCTTTT
TACCTCACAGTCAGGCGTTAGCCGTCATATTCGGGAACTGGAGGATGAACTTGGCATCGAAATATTTGTTCGACGAGGTA
AGCGACTGCTGGGCATGACTGAACCGGGCAAAGCATTACTGGTCATTGCAGAACGTATTCTGAATGAAGCCAGTAATGTT
CGTCGGCTTGCAGACCTGTTTACCAACGATACGTCTGGTGTTCTCACTATTGCAACGACGCATACTCAGGCACGTTATAG
CTTGCCAGAGGTCATTAAAGCTTTTCGCGAACTTTTCCCGGAGGTTCGGCTCGAGCTAATCCAGGGTACGCCACAGGAAA
TTGCGACGTTGTTGCAAAATGGCGAAGCTGATATTGGTATCGCCAGCGAGCGTTTGAGTAATGACCCGCAGCTCGTCGCC
TTCCCGTGGTTTCGCTGGCACCATAGTTTGCTTGTTCCACTCGATCATCCCTTGACGCAAATTACACCGTTGACGCTGGA
ATCAATAGCGAAGTGGCCGTTAATTACTTACCGACAGGGGATTACGGGGCGCTCACGCATTGATGACGCATTTGCCCGCA
AAGGTTTGCCGGCAGATATTGTATTAAGTGCACAGGATTCTGATGTCATTAAAACCTATGTTGCTCTTGGGCTTGGGATC
GGATTAGTTGCCGAACAATCCAGCGGCGAACAAGAGGAAAAGAATTTAATCCGCCTGGATACGCGGCATCTTTTCGATGC
TAATACTGTCTGGTTGGGACTGAAGCGAGGGCAACTTCAGCGTAACTATGTCTGGCGCTTTCTGGAACTTTGTAATGCAG
GACTGTCAGTTGAGGATATCAAGCGCCAGGTGATGGAAAACAGTGAAGAGGAAATTGATTATCAGATATAG

Upstream 100 bases:

>100_bases
CGTTATATCGGGATGGAATAAGATGCGGGTTTTTATTATTTGTTATGCCGGGCATTAGACTTTAACAATAACGGGATATC
TGAACTGCCCGGAGTTTACC

Downstream 100 bases:

>100_bases
CAAAAGGCCCGCTATAAAAGCGGGCTTTTCAGAAATTTGGCTCCTCTGACTGGACTCGAACCAGTGACATACGGATTAAC
AGTCCGCCGTTCTACCGACT

Product: transcriptional regulator Cbl

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLPADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEKNLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Sequences:

>Translated_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLPADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEKNLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI
>Mature_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLPADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEKNLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=98.4177215189873, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI1787530, Length=313, Percent_Identity=41.2140575079872, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1788481, Length=294, Percent_Identity=28.2312925170068, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=28.9855072463768, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=28.0851063829787, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=28.5140562248996, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693105, Length=232, Percent_Identity=25, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082132, Length=134, Percent_Identity=35.0746268656716, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=29.3269230769231, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35857; Mature: 35857

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLPADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEKNLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLPADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEKNLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]