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The map label for this gene is ybhO

Identifier: 218699161

GI number: 218699161

Start: 805311

End: 806552

Strand: Reverse

Name: ybhO

Synonym: ECIAI39_0765

Alternate gene names: 218699161

Gene position: 806552-805311 (Counterclockwise)

Preceding gene: 218699162

Following gene: 218699160

Centisome position: 15.72

GC content: 54.59

Gene sequence:

>1242_bases
ATGAAATGTAGCTGGCGCGAAGGTAATAAGATCCAGTTGCTGGAAAACGGCGAGCAATATTATCCCGCGGTGTTTAAGGC
GATTGGCGAGGCACAAGAACGCATCATTCTTGAAACGTTTATCTGGTTTGAGGATGATGTCGGCAAACAGCTGCATGCGG
CACTACTGGCAGCAGCGCAACGCGGGGTAAAAGCGGAAGTCTTGCTGGATGGCTACGGTTCGCCGGATCTCAGCGATGAG
TTTGTCAATGAACTGACGGCAGCTGGCGTGGTGTTCCGCTACTACGATCCCCGCCCTCGCCTTTTTGGTATGCGCACCAA
TGTGTTTCGCCGGATGCATCGCAAAATTGTGGTGATCGACGCGCATATCGCCTTTATTGGCGGGCTGAATTACTCCGCCG
AGCATATGTCCAGCTACGGTCCAGAGGCTAAACAGGATTACGCGGTGCGCCTTGAAGGGCCGATTGTCGAAGATATTCTG
CAATTTGAACTGGAAAACCTGCCAGGACAGAGCGCGGCACGACGCTGGTGGCGACGTCATCACAAAGCGGAAGAGAACCG
CCAGCCGGGAGAAGCGCAGGTATTGCTGGTCTGGCGCGATAACGAAGAACATCGCGATGATATTGAACGTCACTATCTGA
AAATGCTCACTCAGGCGCGGCGAGAAGTGATTATCGCCAACGCCTACTTCTTCCCCGGCTATCGTTTTTTACACGCCTTG
CGTAAAGCGGCACGGCGCGGGGTGCGGATCAAACTGATCATTCAGGGCGAACCGGATATGCCGATTGTCAGAGTCGGCGC
ACGTTTGCTGTATAACTATCTGGTTAAAGGCGGCGTTCAGGTGTTTGAGTACCGCCGCCGCCCACTCCACGGCAAAGTAG
CATTGATGGACGATCACTGGGCGACAGTAGGGTCCAGTAATCTCGATCCGCTCAGTTTGTCACTGAATCTCGAAGCAAAT
GTCATCATCCACGATCGTCATTTTAACCAGACGCTGCGCGATAATCTGAACGGCATCATCGCCGCAGATTGTCAGCAGGT
CGATGAGACCATGCTGCCGAAACGCACCTGGTGGAATCTGACCAAAAGCGTGCTGGCCTTCCACTTTTTACGCCACTTCC
CGGCGCTGGTCGGCTGGCTTCCGGCACACACGCCACGTCTGGCGCAGGTTGACCCGCCCGCTCAGCCGACAATGGAAACG
CAGGATCGGGTAGAAACTGAAAACACGGGGGTAAAACCCTGA

Upstream 100 bases:

>100_bases
TCTACGTCAAAAATGCCAGCACCAGCGCGCCAACCGCGTTGCCGCTGCGGACATGGCGACACCTTTCTGATCATGCCCCT
TTAAGTGCGGAGATTCATTT

Downstream 100 bases:

>100_bases
TGAGTAAATCACACCCGCGCTGGCGCTTAGCAAAGAAGATCCTCACCTGGCTGTTTTTTATCGCGGTGATTGTGTTGTTG
GTGGTCTACGCCAAAAAAGT

Product: cardiolipin synthase 2

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDAHIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMET
QDRVETENTGVKP

Sequences:

>Translated_413_residues
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDAHIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMET
QDRVETENTGVKP
>Mature_413_residues
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDAHIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMET
QDRVETENTGVKP

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=413, Percent_Identity=99.7578692493947, Blast_Score=852, Evalue=0.0,
Organism=Escherichia coli, GI1787502, Length=400, Percent_Identity=25.25, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081826, Length=399, Percent_Identity=23.0576441102757, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 47615; Mature: 47615

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCEECHHHHHHHHHCCEEEEEE
AHIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRH
EEEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH
HKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
HHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHH
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRVETENTGVKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKCSWREGNKIQLLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCEECHHHHHHHHHCCEEEEEE
AHIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRH
EEEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH
HKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQARREVIIANAYFFPGYRFLHAL
HHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHH
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPRLAQVDPPAQPTMETQDRVETENTGVKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]