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The map label for this gene is metH

Identifier: 218697721

GI number: 218697721

Start: 4612746

End: 4616429

Strand: Direct

Name: metH

Synonym: EC55989_4504

Alternate gene names: 218697721

Gene position: 4612746-4616429 (Clockwise)

Preceding gene: 218697719

Following gene: 218697722

Centisome position: 89.48

GC content: 55.67

Gene sequence:

>3684_bases
GTGAGCAGCAAAGTGGAACAACTGCGTGCGCAGTTAAATGAACGTATTCTGGTGCTGGACGGCGGTATGGGCACCATGAT
CCAGAGCTATCGACTGAACGAAGCCGATTTTCGTGGTGAACGCTTTGCCGACTGGCCATGCGATCTCAAAGGCAACAACG
ACCTGCTGGTGCTCAGCAAACCGGAAGTGATCGCCGCTATCCACAACGCCTACTTTGAAGCGGGCGCGGATATCATCGAA
ACCAACACCTTTAACTCCACGACCATTGCGATGGCGGATTACCAGATGGAATCCCTGTCGGCGGAAATCAACTTTGCGGC
GGCGAAACTGGCGCGAGCTTGTGCTGATGAGTGGACCGCGCGCACGCCGGAGAAACCGCGCTACGTTGCCGGTGTTCTCG
GCCCGACCAACCGCACGGCGTCTATTTCTCCGGACGTAAATGATCCGGCATTTCGTAATATCACTTTTGACGGGCTGGTG
GCGGCTTATCGAGAGTCCACCAAAGCGCTGGTGGAAGGTGGTGCGGATCTGATCCTGATTGAAACCGTTTTCGACACCCT
TAACGCCAAAGCGGCGGTTTTTGCGGTGAAAACGGAGTTTGAAGCGCTGGGCGTTGAGCTGCCGATTATGATCTCCGGCA
CCATCACCGACGCCTCCGGGCGCACGCTCTCCGGGCAGACCACCGAAGCATTTTACAACTCATTGCGCCACGCCGAAGCT
CTGACCTTTGGCCTGAACTGTGCGCTGGGGCCCGATGAACTGCGCCAGTACGTGCAGGAGCTGTCACGGATTGCGGAATG
CTACGTCACCGCGCACCCGAACGCCGGGCTACCCAACGCCTTTGGTGAGTACGATCTCGACGCCGACACGATGGCAAAAC
AGATACGTGAATGGGCGCAAGCGGGTTTTCTCAATATCGTCGGCGGCTGCTGTGGCACCACGCCACAACATATTGCAGCG
ATGAGTCGTGCAGTAGAAGGATTAGCGCCGCGCAAACTGCCGGAAATCCCCGTAGCCTGCCGTTTGTCCGGCCTGGAGCC
GCTGAACATTGGCGAAGATAGCCTGTTTGTGAACGTGGGTGAACGCACCAACGTCACCGGTTCCGCTAAGTTCAAGCGCC
TGATCAAAGAAGAGAAATACAGCGAGGCACTGGATGTGGCCCGCCAGCAGGTGGAAAACGGTGCGCAGATTATCGATATC
AACATGGATGAAGGGATGCTCGACGCCGAAGCGGCGATGGTGCGTTTTCTCAATCTGATTGCCGGTGAACCGGATATCGC
TCGCGTGCCGATTATGATCGACTCCTCAAAATGGGATGTCATTGAAAAAGGTCTGAAGTGTATCCAGGGCAAAGGCATTG
TTAACTCTATCTCGATGAAAGAGGGCGTCGACGCCTTTATCCATCACGCGAAGCTCTTGCGTCGTTACGGTGCGGCAGTG
GTGGTAATGGCCTTTGACGAACAGGGACAGGCCGATACCCGCGCACGGAAAATCGAGATTTGCCGTCGGGCGTACAAAAT
CCTCACCGAAGAGGTTGGCTTCCCGCCAGAAGATATCATCTTCGACCCGAACATCTTCGCGGTCGCAACCGGCATTGAAG
AGCACAACAACTACGCGCAGGACTTTATCGGCGCGTGTGAAGATATCAAACGCGAACTGCCGCACGCGCTGATTTCCGGC
GGTGTATCTAACGTTTCTTTCTCATTCCGTGGCAACGATCCGGTGCGCGAAGCCATTCACGCGGTGTTCCTCTACTACGC
TATTCGCAATGGCATGGATATGGGGATCGTCAACGCCGGGCAACTGGCGATTTACGACGACCTACCCGCTGAACTGCGCG
ACGCGGTGGAAGATGTGATTCTTAACCGTCGCGACGATGGCACTGAGCGTTTACTGGAGCTTGCCGAGAAATATCGCGGC
AGCAAAACCGACGACACCGCTAACGCCCAGCAGGCGGAGTGGCGCTCGTGGGAAGTGAATAAACGTCTGGAATACTCGCT
GGTTAAAGGCATTACCGAGTTTATCGAGCAGGATACCGAAGAAGCCCGCCAGCAGGCTACGCGCCCGATTGAAGTGATTG
AAGGCCCGCTGATGGACGGTATGAACGTGGTCGGCGATCTGTTTGGCGAAGGGAAAATGTTCCTGCCACAGGTGGTCAAA
TCGGCGCGCGTCATGAAACAGGCAGTGGCGTATCTCGAACCGTTTATTGAAGCCAGCAAAGAGCAGGGTAAAACCAACGG
CAAGATGGTGATCGCCACCGTGAAAGGCGATGTCCACGACATCGGTAAAAATATCGTTGGCGTGGTGCTGCAATGTAACA
ACTACGAAATTGTCGATCTCGGCGTTATGGTGCCTGCGGAAAAAATTCTCCGTACCGCTAAAGAAGTGAATGCTGATCTG
ATTGGACTTTCGGGGCTTATCACGCCGTCGCTGGACGAGATGGTTAACGTGGCGAAAGAGATGGAGCGTCAGGGCTTCAC
CATCCCGCTATTGATTGGCGGCGCGACGACCTCAAAAGCGCACACGGCGGTGAAAATTGAGCAGAACTACAGCGGCCCGA
CGGTGTATGTACAGAACGCATCGCGCACCGTTGGTGTGGTGGCGGCGCTGCTTTCCGATACTCAGCGTGATGATTTTGTC
GCTCGTACCCGCAAGGAGTACGAAACCGTACGTATTCAGCACGGGCGTAAGAAACCGCGCACACCACCGGTCACGCTGGA
AGCGGCGCGCGATAACGATTTCGCTTTTGACTGGCAGGCTTACACGCCGCCGGTGGCGCACCGTCTCGGCGTGCAGGAAG
TTGAAGCCAGCATCGAAACTCTGCGTAATTACATCGACTGGACACCGTTCTTTATGACCTGGTCGCTGGCCGGGAAGTAT
CCGCGCATTCTGGAAGATGAAGTGGTGGGCGTTGAGGCGCAGCGGCTGTTTAAAGACGCCAACGACATGCTGGATAAATT
AAGCGCCGAGAAAACGCTGAATCCGCGTGGCGTGGTGGGCCTGTTCCCGGCAAACCGTGTGGGCGATGACATTGAAATCT
ACCGTGACGAAACGCGCACCCATGTGATCAACGTCAGCCACCATCTGCGTCAACAGACCGAAAAAACGGGATTCGCTAAC
TACTGTCTCGCTGACTTCGTTGCGCCGAAGCTTTCTGGTAAAGCAGATTACATCGGCGCATTTGCCGTGACTGGCGGGCT
GGAAGAGGACGCACTGGCTGATGCCTTTGAAGCGCAGCACGATGATTACAACAAAATCATGGTGAAAGCGCTTGCCGACC
GTCTGGCGGAAGCCTTTGCGGAGTATCTCCATGAGCGTGTGCGTAAAGTCTACTGGGGCTATGCGCCGAACGAGAACCTC
AGCAACGAAGAACTGATCCGCGAAAACTACCAGGGCATCCGTCCGGCACCGGGCTATCCGGCCTGCCCGGAACATACGGA
AAAAGCCACCATCTGGGAGCTGCTGGAAGTGGAAAAACACACTGGCATGAAACTCACAGAATCTTTCGCCATGTGGCCCG
GTGCATCGGTTTCGGGTTGGTACTTCAGCCACCCGGACAGCAAGTACTACGCTGTAGCACAAATTCAGCGCGATCAGGTT
GAAGATTATGCCCGCCGTAAAGGTATGAGCGTTACCGAAGTTGAGCGCTGGCTGGCACCGAATCTGGGGTATGACGCGGA
CTGA

Upstream 100 bases:

>100_bases
TCTCATGTTGCGTGGTGGTCGCTTTTACCACAGATGCGTTTATGCCAGTATGGTTTGTTGAATTTTTATTAAATCTGGGT
TGAGCGTGTCGGGAGCAAGT

Downstream 100 bases:

>100_bases
TTCACAAATCTGTCACTTTTCCTTACAACAAACAGGGCGCTCAATGAGTGCCCTGTCTCTTTATTAATATGAAACACTTA
TACTGGAAACAGGCTGGAAT

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS

Number of amino acids: Translated: 1227; Mature: 1226

Protein sequence:

>1227_residues
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIE
TNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLV
AAYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLNIVGGCCGTTPQHIAA
MSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDI
NMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISG
GVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRG
SKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADL
IGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFV
ARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFAN
YCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENL
SNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVTEVERWLAPNLGYDAD

Sequences:

>Translated_1227_residues
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIE
TNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLV
AAYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLNIVGGCCGTTPQHIAA
MSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDI
NMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISG
GVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRG
SKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADL
IGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFV
ARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFAN
YCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENL
SNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVTEVERWLAPNLGYDAD
>Mature_1226_residues
SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIET
NTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVA
AYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEAL
TFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLNIVGGCCGTTPQHIAAM
SRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDIN
MDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVV
VMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGG
VSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGS
KTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKS
ARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLI
GLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVA
RTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYP
RILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANY
CLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLS
NEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVE
DYARRKGMSVTEVERWLAPNLGYDAD

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Homo sapiens, GI169790923, Length=1252, Percent_Identity=54.073482428115, Blast_Score=1322, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1227, Percent_Identity=100, Blast_Score=2538, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=329, Percent_Identity=24.0121580547112, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17535405, Length=1251, Percent_Identity=53.1574740207834, Blast_Score=1289, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): METH_ECOLI (P13009)

Other databases:

- EMBL:   X16584
- EMBL:   J04975
- EMBL:   U00006
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   B65209
- RefSeq:   AP_004520.1
- RefSeq:   NP_418443.1
- PDB:   1BMT
- PDB:   1K7Y
- PDB:   1K98
- PDB:   1MSK
- PDB:   3BUL
- PDB:   3IV9
- PDB:   3IVA
- PDBsum:   1BMT
- PDBsum:   1K7Y
- PDBsum:   1K98
- PDBsum:   1MSK
- PDBsum:   3BUL
- PDBsum:   3IV9
- PDBsum:   3IVA
- ProteinModelPortal:   P13009
- SMR:   P13009
- STRING:   P13009
- SWISS-2DPAGE:   P13009
- PRIDE:   P13009
- EnsemblBacteria:   EBESCT00000002831
- EnsemblBacteria:   EBESCT00000018146
- GeneID:   948522
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3979
- KEGG:   eco:b4019
- EchoBASE:   EB0582
- EcoGene:   EG10587
- eggNOG:   COG1410
- GeneTree:   EBGT00050000010605
- HOGENOM:   HBG289648
- OMA:   YVTDASR
- ProtClustDB:   PRK09490
- BioCyc:   EcoCyc:HOMOCYSMETB12-MONOMER
- BioCyc:   MetaCyc:HOMOCYSMETB12-MONOMER
- Genevestigator:   P13009
- GO:   GO:0005737
- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223
- Gene3D:   G3DSA:3.40.50.280
- Gene3D:   G3DSA:3.20.20.20
- Gene3D:   G3DSA:3.10.196.10
- Gene3D:   G3DSA:1.10.1240.10
- Gene3D:   G3DSA:3.20.20.330
- PIRSF:   PIRSF000381
- TIGRFAMs:   TIGR02082

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans; SSF52242 Cbl-bd; SSF51717 DHP_synth_like; SSF56507 Met_synth_B12; SSF47644 Met_synth_Cbl-bd; SSF82282 S_methyl_trans

EC number: =2.1.1.13

Molecular weight: Translated: 135998; Mature: 135867

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50974 ADOMET_ACTIVATION; PS51332 B12_BINDING; PS51337 B12_BINDING_NTER; PS50970 HCY; PS50972 PTERIN_BINDING

Important sites: BINDING 804-804 BINDING 946-946 BINDING 1134-1134 BINDING 1138-1138

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
CCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
CHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILI
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEH
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
HHHHHHHCCCEEEEEEEEHHHHHCEEEEEEEEEEEECCCCCEECCCHHHHHHHHHHHHHH
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
HHCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCCCCCCCEEEECC
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
CCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCEE
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEEECCHHHCCHHH
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECCC
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
CEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHCHHHHHHHHHCCCCCHHHHHHH
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCHHEEEEEEECCEEEEEE
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
EEECCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
EEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
CCCEEEEECCCCCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHEEECCCCE
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
EEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHCC
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
CCCCCCCHHHHHHHHHHHHHCCCEEHHHHHCCCCCCCCCCEEECCCCCEEEEHHHHHHHH
EDYARRKGMSVTEVERWLAPNLGYDAD
HHHHHHCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
CHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
CHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILI
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEH
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
HHHHHHHCCCEEEEEEEEHHHHHCEEEEEEEEEEEECCCCCEECCCHHHHHHHHHHHHHH
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
HHCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCCCCCCCEEEECC
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
CCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCEE
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEEECCHHHCCHHH
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECCC
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
CEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHCHHHHHHHHHCCCCCHHHHHHH
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCHHEEEEEEECCEEEEEE
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
EEECCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
EEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
CCCEEEEECCCCCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHEEECCCCE
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
EEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHCC
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
CCCCCCCHHHHHHHHHHHHHCCCEEHHHHHCCCCCCCCCCEEECCCCCEEEEHHHHHHHH
EDYARRKGMSVTEVERWLAPNLGYDAD
HHHHHHCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2185137; 2668277; 8369296; 8265357; 9278503; 1593636; 7992050; 8939751