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The map label for this gene is arsR

Identifier: 218697209

GI number: 218697209

Start: 4013336

End: 4013689

Strand: Direct

Name: arsR

Synonym: EC55989_3942

Alternate gene names: 218697209

Gene position: 4013336-4013689 (Clockwise)

Preceding gene: 218697208

Following gene: 218697210

Centisome position: 77.86

GC content: 50.85

Gene sequence:

>354_bases
ATGTCATTTCTGTTACCCATCCAATTGTTCAAAATTCTTGCTGATGAAACCCGTCTGGGCATCGTTTTACTGCTCAGCGA
ACTGGGAGAGTTATGCGTCTGCGATCTCTGCACTGCTCTCGACCAGTCGCAGCCCAAGATCTCCCGCCACCTGGCATTGC
TGCGTGAAAGCGGGCTATTGCTGGACCGCAAGCAAGGTAAGTGGGTTCATTACCGCTTATCACCGCATATTCCAGCATGG
GCGGCGAAAATTATTGATGAGGCCTGGCGATGTGAACAGGAAAAGGTTCAGGCGATTGTCCGCAACCTGGCTCGACAAAA
CTGTTCCGGGGACAGTAAGAACATTTGCAGTTAA

Upstream 100 bases:

>100_bases
CTATTACCTTCCTCTGCACTTACACATTCGTTAAGTCATATATGTTTTTGACTTATCCGCTTCGAAGAGAGACACTACCT
GCAACAATCAGGAGCGCAAT

Downstream 100 bases:

>100_bases
AAATTTAGCTAAACACATATGAATTTTCAGATGTGTTTTATCCGGGAGGCATTATGTTACTGGCAGGCGCTATCTTTGTC
CTGACCATCGTATTGGTTAT

Product: DNA-binding transcriptional repressor ArsR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAW
AAKIIDEAWRCEQEKVQAIVRNLARQNCSGDSKNICS

Sequences:

>Translated_117_residues
MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAW
AAKIIDEAWRCEQEKVQAIVRNLARQNCSGDSKNICS
>Mature_116_residues
SFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA
AKIIDEAWRCEQEKVQAIVRNLARQNCSGDSKNICS

Specific function: Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arse

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789916, Length=117, Percent_Identity=100, Blast_Score=237, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARSR_ECOLI (P37309)

Other databases:

- EMBL:   X80057
- EMBL:   U00039
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   A56269
- RefSeq:   AP_004292.1
- RefSeq:   NP_417958.1
- ProteinModelPortal:   P37309
- SMR:   P37309
- DIP:   DIP-9163N
- STRING:   P37309
- EnsemblBacteria:   EBESCT00000001364
- EnsemblBacteria:   EBESCT00000015346
- GeneID:   948013
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3468
- KEGG:   eco:b3501
- EchoBASE:   EB2147
- EcoGene:   EG12235
- eggNOG:   COG0640
- GeneTree:   EBGT00050000009971
- HOGENOM:   HBG742701
- OMA:   VASNCLK
- ProtClustDB:   PRK10141
- BioCyc:   EcoCyc:EG12235-MONOMER
- Genevestigator:   P37309
- GO:   GO:0005622
- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00778
- SMART:   SM00418

Pfam domain/function: PF01022 HTH_5

EC number: NA

Molecular weight: Translated: 13253; Mature: 13122

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00846 HTH_ARSR_1; PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCE
LDRKQGKWVHYRLSPHIPAWAAKIIDEAWRCEQEKVQAIVRNLARQNCSGDSKNICS
EECCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQPKISRHLALLRESGLL
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCE
LDRKQGKWVHYRLSPHIPAWAAKIIDEAWRCEQEKVQAIVRNLARQNCSGDSKNICS
EECCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721697; 8041620; 9278503