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The map label for this gene is frlB

Identifier: 218697052

GI number: 218697052

Start: 3835801

End: 3836823

Strand: Direct

Name: frlB

Synonym: EC55989_3777

Alternate gene names: 218697052

Gene position: 3835801-3836823 (Clockwise)

Preceding gene: 218697051

Following gene: 218697053

Centisome position: 74.41

GC content: 54.84

Gene sequence:

>1023_bases
ATGTTGGATATTGATAAAAGCACCGTGGACTTTCTGGTCACCGAAAATATGGTTCAGGAAGTGGAAAAAGTTCTCAGCCA
TGACGTTCCGCTGGTGCACGCCATCGTGGAAGAGATGGTGAAGCGCGACATTGATCGTATTTATTTCGTTGCCTGCGGCT
CGCCACTCAACGCGGCGCAAACGGCGAAACATCTGGCGGATCGCTTTTCCGATCTTCAGGTCTACGCCATTTCCGGCTGG
GAGTTCTGCGATAACACCCCGTATCGCCTCGACGATCGTTGCGCGGTGATTGGCGTTTCTGACTACGGTAAAACGGAAGA
GGTAATCAAAGCGCTGGAGCTGGGCCGGGCCTGCGGCGCACTCACTGCGGCGTTCACCAAACGCGCGGACAGCCCGATTA
CCTCGGCGGCGGAATTTAGCATTGATTATCAGGCCGACTGTATCTGGGAAATTCACCTGCTGCTCTGCTACAGCGTGGTG
CTGGAGATGATCACCCGCCTCGCGCCGAACGCGGAAATCGGCAAGATCAAAAACGATCTCAAGCAGTTGCCGAATGCGCT
CGGTCATCTGGTACGCACCTGGGAAGAAAAAGGCCGCCAGCTTGGTGAACTGGCCAGCCAGTGGCCGATGATTTATACCG
TTGCTGCGGGTCCGCTGCGTCCGCTGGGTTACAAAGAAGGCATTGTAACGCTGATGGAATTTACCTGGACGCACGGCTGC
GTGATTGAGAGCGGAGAGTTCCGCCATGGCCCGCTGGAGATTGTCGAACCGGGCGTTCCGTTCCTGTTCCTGCTCGGCAA
TGATGAAAGTCGCCACACCACCGAACGCGCCATTAACTTTGTTAAACAGCGTACTGACAACGTGATCGTCATCGATTACG
CCGAAATTTCGCAAGGGCTGCACCCGTGGCTGGCACCGTTCCTGATGTTCGTGCCAATGGAGTGGCTCTGCTACTACCTG
TCTATTTACAAAGATCACAACCCGGATGAACGCCGCTATTACGGTGGTCTGGTGGAATATTAA

Upstream 100 bases:

>100_bases
CCGTCATCGTTATTGCTACTGGTCTGCCTGCTTACGCCTTCTGGGCGAAGCGTAGCCGCCAGCTCAACGCTTTGTCGTAA
TGTTATCTGGAGAAAATAAA

Downstream 100 bases:

>100_bases
TCCCTCTCCCGGCCCGGCAACGGGCCGAATTTACGCAAGGAGTTACCCGATGAAAACAGGTATGTTTACCTGCGGCCACC
AGCGGCTGCCTATTGAACAC

Product: fructoselysine-6-P-deglycase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQVYAISGW
EFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVV
LEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGC
VIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPMEWLCYYL
SIYKDHNPDERRYYGGLVEY

Sequences:

>Translated_340_residues
MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQVYAISGW
EFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVV
LEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGC
VIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPMEWLCYYL
SIYKDHNPDERRYYGGLVEY
>Mature_340_residues
MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQVYAISGW
EFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVV
LEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGC
VIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPMEWLCYYL
SIYKDHNPDERRYYGGLVEY

Specific function: Catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=311, Percent_Identity=22.508038585209, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082251, Length=340, Percent_Identity=100, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532899, Length=311, Percent_Identity=23.7942122186495, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532897, Length=311, Percent_Identity=23.7942122186495, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 38570; Mature: 38570

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQ
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHH
TAKHLADRFSDLQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGA
HHHHHHHHHCCEEEEEEECCHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEIGKIKNDL
HHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
VIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGL
EEECCCCCCCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHCCC
HPWLAPFLMFVPMEWLCYYLSIYKDHNPDERRYYGGLVEY
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQ
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHH
TAKHLADRFSDLQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGA
HHHHHHHHHCCEEEEEEECCHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEIGKIKNDL
HHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
VIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGL
EEECCCCCCCCHHEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHCCC
HPWLAPFLMFVPMEWLCYYLSIYKDHNPDERRYYGGLVEY
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]