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The map label for this gene is gltB

Identifier: 218696917

GI number: 218696917

Start: 3711878

End: 3716431

Strand: Direct

Name: gltB

Synonym: EC55989_3630

Alternate gene names: 218696917

Gene position: 3711878-3716431 (Clockwise)

Preceding gene: 218696912

Following gene: 218696918

Centisome position: 72.01

GC content: 57.03

Gene sequence:

>4554_bases
ATGACACGCAAACCCCGTCGCCACGCTCTTTCTGTGCCCGTGCGCAGCGGTTCGGAAGTGGGGTTCCCGCAGAGCCTGGG
GGAGGTTCACGATATGTTGTACGATAAATCCCTTGAGAGGGATAACTGTGGTTTCGGCCTGATCGCCCACATAGAAGGCG
AACCTAGCCACAAGGTAGTGCGTACTGCAATACACGCACTGGCCCGCATGCAGCACCGTGGCGCGATTCTCGCCGATGGT
AAAACCGGCGACGGTTGCGGCTTGCTGTTACAAAAACCGGATCGCTTTTTTCGCATCGTTGCGCAGGAGCGCGGCTGGCG
TTTAGCAAAAAACTACGCTGTCGGGATGCTCTTCCTGAATAAAGATCCTGAACTCGCCGCTGCCGCACGCCGCATCGTTG
AAGAAGAGCTGCAACGCGAAACCTTGTCGATTGTGGGCTGGCGTGATGTCCCCACTAACGAAGGCGTGCTGGGTGAAATC
GCCCTCTCCTCTCTGCCCCACATTGAGCAAATTTTCGTTAACGCTCCGGCAGGCTGGCGTCCGCGCGATATGGAGCGCCG
TCTGTTTATCGCCCGCCGCCGCATTGAAAAGCGTCTCGAAGCCGACAAAGACTTCTACGTCTGTAGCCTGTCGAATCTGG
TGAACATCTATAAAGGTCTGTGTATGCCGGCGGATCTGCCGCGCTTTTATCTGGATCTTGCGGACCTGCGTCTGGAATCG
GCCATCTGCCTGTTCCACCAGCGCTTCTCCACTAACACCGTACCGCGCTGGCCGCTGGCGCAGCCGTTCCGCTACCTGGC
GCATAACGGTGAAATCAACACCATCACCGGTAACCGCCAATGGGCGCGTGCGCGTACCTATAAATTCCAGACGCCGCTGA
TCCCTGATCTGCACGACGCCGCACCGTTCGTCAACGAAACCGGTTCTGACTCCAGTTCGATGGATAACATGCTGGAACTG
CTGCTGGCAGGCGGGATGGATATCATCCGCGCCATGCGTCTATTAGTACCACCCGCCTGGCAGAACAACCCGGATATGGA
CCCGGAACTGCGTGCCTTCTTTGACTTTAACTCCATGCATATGGAGCCGTGGGATGGCCCGGCGGGCATCGTGATGTCCG
ATGGTCGCTTCGCTGCCTGTAACCTCGACCGTAACGGTCTGCGTCCGGCACGCTACGTCATTACCAAAGACAAGCTCATC
ACCTGCGCCTCTGAAGTCGGTATCTGGGATTATCAGCCTGACGAAGTGGTCGAAAAAGGCCGCGTCGGGCCAGGCGAACT
GATGGTGATCGACACCCGCAGTGGGCGTATTCTGCACTCGGCAGAAACCGATGACGATCTGAAAAGCCGCCATCCATATA
AAGAGTGGATGGAGAAAAACGTCCGCCGACTGGTACCGTTTGAAGATCTGCCCGATGAAGAAGTGGGTAGCCGCGAACTG
GACGACGACACGCTTGCCAGCTACCAGAAACAGTTTAACTACAGCGCGGAAGAGCTGGACTCCGTAATTCGCGTACTGGG
CGAAAACGGTCAGGAAGCGGTCGGTTCGATGGGCGATGATACCCCATTCGCCGTGCTCTCCAGTCAGCCGCGCATTATTT
ACGACTACTTCCGCCAGCAGTTTGCCCAGGTGACTAACCCGCCAATCGACCCGCTGCGTGAAGCGCATGTTATGTCGCTC
GCCACCAGTATCGGTCGTGAAATGAACGTCTTTTGCGAAGCAGAGGGCCAGGCGCACCGTTTAAGCTTTAAATCGCCGAT
TCTGCTCTACTCCGATTTCAAACAGCTCACGACGATGAAAGAGGAGCACTACCGCGCAGATACGCTGGATATCACCTTTG
ACGTCACTAAAACCACGCTCGAAGCGACAGTCAAAGAGCTGTGCGACAAAGCCGAAAAAATGGTACGTAGCGGCACCGTG
CTGCTGGTGCTCTCCGACCGGAATATCGCTAAAGATCGCCTGCCGGTTCCAGCCCCGATGGCGGTTGGCGCGATCCAGAC
CCGTCTGGTCGATCAAAGCCTGCGTTGCGATGCCAACATCATCGTCGAAACCGCCAGCGCCCGCGATCCGCACCACTTCG
CCGTGTTGCTGGGCTTCGGCGCGACGGCTATTTATCCATACCTTGCCTATGAAACGCTGGGCCGCCTGGTAGACACCCAT
GCGATTGCCAAAGATTATCGTACCGTGATGCTCAACTACCGTAACGGCATCAACAAAGGCTTGTACAAAATCATGTCCAA
AATGGGCATCTCCACCATCGCCTCTTACCGCTGCTCGAAACTGTTTGAAGCGGTCGGTCTGCACGATGATGTAGTGGGCC
TGTGCTTCCAGGGGGCGGTCAGCCGCATTGGTGGGGCGAGCTTTGAAGACTTCCAGCAGGATCTGCTGAACCTGTCGAAA
CGTGCCTGGCTGGCGCGTAAGCCCATCAGCCAGGGCGGCCTGCTGAAATACGTCCACGGCGGCGAATACCACGCTTACAA
CCCGGACGTGGTGCGCACGCTGCAACAGGCGGTACAAAGCGGCGAGTACAGCGACTATCAGGAATACGCGAAGCTGGTTA
ATGAGCGTCCGGCAACCACGCTGCGCGATCTGCTGGCAATTACGCCGGGTGAAAACGCGGTCAACATTGCTGATGTTGAA
CCGGCAAGCGAACTGTTTAAACGCTTTGATACCGCCGCGATGTCTATCGGCGCGTTAAGCCCGGAAGCCCACGAGGCGCT
GGCGGAAGCGATGAATAGCATCGGCGGTAACTCGAACTCCGGTGAAGGCGGCGAAGACCCGGCGCGCTATGGCACTAACA
AAGTGTCGCGCATCAAGCAGGTGGCTTCTGGTCGCTTCGGCGTTACTCCGGCGTATCTGGTCAATGCCGACGTCATTCAG
ATTAAAGTCGCCCAGGGCGCGAAGCCGGGCGAAGGCGGTCAGTTGCCGGGCGACAAAGTCACTCCTTACATCGCCAAACT
GCGCTATTCGGTGCCCGGAGTGACGCTGATCTCCCCGCCGCCGCACCACGATATCTACTCTATCGAGGACTTAGCGCAGC
TCATTTTCGACCTCAAGCAGGTTAACCCGAAAGCGATGATCTCCGTGAAGCTGGTTTCCGAACCGGGCGTAGGCACCATC
GCGACTGGCGTGGCAAAAGCTTATGCCGATTTAATCACCATCGCAGGCTATGACGGTGGCACCGGCGCAAGCCCGCTGTC
GTCAGTGAAATACGCAGGTTGCCCGTGGGAGCTGGGGCTTGTTGAAACCCAGCAGGCGCTGGTTGCCAATGGTCTGCGTC
ATAAGATCCGTTTGCAGGTCGATGGCGGCCTGAAAACCGGTGTTGATATCATCAAAGCGGCGATTCTCGGCGCAGAAAGC
TTCGGCTTCGGCACTGGCCCGATGGTGGCGCTCGGCTGTAAATATCTACGTATTTGCCATCTGAACAACTGCGCAACGGG
TGTAGCAACTCAGGATGACAAACTGCGTAAGAACCACTATCACGGCCTGCCGTTCAAGGTTACCAATTACTTTGAATTTA
TTGCCCGTGAAACCCGCGAGCTGATGGCACAGCTGGGCGTAACGCGTCTGGTGGATCTGATTGGTCGCACCGACCTGCTG
AAAGAACTGGACGGTTTCACCGCCAAACAGCAAAAACTGGCGCTGTCGAAGCTGCTGGAGACCGCCGAACCGCATCCAGG
TAAGGCACTCTACTGCACCGAAAACAACCCACCGTTTGATAACGGCCTGCTGAACGCGCAGTTGCTGCAACAGGCGAAAC
CGTTTGTCGATGAACGCCAGAGCAAAACCTTCTGGTTCGATATTCGCAACACCGACCGTTCTGTCGGCGCGTCGCTTTCA
GGCTATATCGCCCAGACGCACGGCGATCAGGGGCTGGCAGCCGATCCTATCAAAGCGTACTTCAACGGCACCGCAGGCCA
GAGTTTCGGTGTGTGGAACGCGGGCGGCGTGGAACTGTACCTGACCGGGGATGCCAACGACTATGTCGGTAAAGGCATGG
CGGGCGGCTTAATCGCCATTCGTCCTCCGGTTGGTTCCGCCTTCCGCAGCCATGAAGCAAGTATTATCGGCAACACCTGC
CTGTATGGCGCGACCGGTGGTCGTCTGTATGCCGCAGGCCGCGCGGGTGAACGTTTCGGCGTGCGGAACTCCGGTGCTAT
CACCGTGGTAGAAGGCATTGGCGACAACGGCTGTGAATATATGACGGGCGGTATTGTCTGTATTCTGGGTAAAACCGGCG
TTAACTTCGGTGCGGGCATGACCGGCGGCTTCGCTTACGTTCTCGATGAAAGCGGTGATTTCCGCAAACGCGTTAACCCG
GAACTGGTCGAGGTCTTAAGCGTTGACGATCTGGCGATCCATGAAGAGCATCTGCGCGGTCTTATCACCGAGCATGTTCA
GCATACTGGCTCTCAGCGCGGTGAAGAGATTCTGGCGAACTGGTCAACCTTCGCCACTAAATTTGCGCTGGTTAAACCGA
AGTCCAGTGATGTAAAAGCACTGCTGGGTCATCGTAGTCGTAGCGCAGCAGAGTTGCGCGTGCAGGCGCAGTAA

Upstream 100 bases:

>100_bases
AGCAGCCTGCTCATCATATTTATGCAGTAATTGAGATCCCCTCTTCACCGTATTAACCGATGCGAAAAGGACAACAAGGG
GGCGAATGCGAGGCGCGCGT

Downstream 100 bases:

>100_bases
GGGGTAGCAACAATGAGTCAGAATGTTTATCAATTTATCGACCTGCAGCGCGTTGATCCGCCAAAGAAACCGCTGAAGAT
CCGCAAAATTGAGTTTGTTG

Product: glutamate synthase subunit alpha

Products: NA

Alternate protein names: Glutamate synthase subunit alpha; GLTS alpha chain; NADPH-GOGAT [H]

Number of amino acids: Translated: 1517; Mature: 1516

Protein sequence:

>1517_residues
MTRKPRRHALSVPVRSGSEVGFPQSLGEVHDMLYDKSLERDNCGFGLIAHIEGEPSHKVVRTAIHALARMQHRGAILADG
KTGDGCGLLLQKPDRFFRIVAQERGWRLAKNYAVGMLFLNKDPELAAAARRIVEEELQRETLSIVGWRDVPTNEGVLGEI
ALSSLPHIEQIFVNAPAGWRPRDMERRLFIARRRIEKRLEADKDFYVCSLSNLVNIYKGLCMPADLPRFYLDLADLRLES
AICLFHQRFSTNTVPRWPLAQPFRYLAHNGEINTITGNRQWARARTYKFQTPLIPDLHDAAPFVNETGSDSSSMDNMLEL
LLAGGMDIIRAMRLLVPPAWQNNPDMDPELRAFFDFNSMHMEPWDGPAGIVMSDGRFAACNLDRNGLRPARYVITKDKLI
TCASEVGIWDYQPDEVVEKGRVGPGELMVIDTRSGRILHSAETDDDLKSRHPYKEWMEKNVRRLVPFEDLPDEEVGSREL
DDDTLASYQKQFNYSAEELDSVIRVLGENGQEAVGSMGDDTPFAVLSSQPRIIYDYFRQQFAQVTNPPIDPLREAHVMSL
ATSIGREMNVFCEAEGQAHRLSFKSPILLYSDFKQLTTMKEEHYRADTLDITFDVTKTTLEATVKELCDKAEKMVRSGTV
LLVLSDRNIAKDRLPVPAPMAVGAIQTRLVDQSLRCDANIIVETASARDPHHFAVLLGFGATAIYPYLAYETLGRLVDTH
AIAKDYRTVMLNYRNGINKGLYKIMSKMGISTIASYRCSKLFEAVGLHDDVVGLCFQGAVSRIGGASFEDFQQDLLNLSK
RAWLARKPISQGGLLKYVHGGEYHAYNPDVVRTLQQAVQSGEYSDYQEYAKLVNERPATTLRDLLAITPGENAVNIADVE
PASELFKRFDTAAMSIGALSPEAHEALAEAMNSIGGNSNSGEGGEDPARYGTNKVSRIKQVASGRFGVTPAYLVNADVIQ
IKVAQGAKPGEGGQLPGDKVTPYIAKLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQVNPKAMISVKLVSEPGVGTI
ATGVAKAYADLITIAGYDGGTGASPLSSVKYAGCPWELGLVETQQALVANGLRHKIRLQVDGGLKTGVDIIKAAILGAES
FGFGTGPMVALGCKYLRICHLNNCATGVATQDDKLRKNHYHGLPFKVTNYFEFIARETRELMAQLGVTRLVDLIGRTDLL
KELDGFTAKQQKLALSKLLETAEPHPGKALYCTENNPPFDNGLLNAQLLQQAKPFVDERQSKTFWFDIRNTDRSVGASLS
GYIAQTHGDQGLAADPIKAYFNGTAGQSFGVWNAGGVELYLTGDANDYVGKGMAGGLIAIRPPVGSAFRSHEASIIGNTC
LYGATGGRLYAAGRAGERFGVRNSGAITVVEGIGDNGCEYMTGGIVCILGKTGVNFGAGMTGGFAYVLDESGDFRKRVNP
ELVEVLSVDDLAIHEEHLRGLITEHVQHTGSQRGEEILANWSTFATKFALVKPKSSDVKALLGHRSRSAAELRVQAQ

Sequences:

>Translated_1517_residues
MTRKPRRHALSVPVRSGSEVGFPQSLGEVHDMLYDKSLERDNCGFGLIAHIEGEPSHKVVRTAIHALARMQHRGAILADG
KTGDGCGLLLQKPDRFFRIVAQERGWRLAKNYAVGMLFLNKDPELAAAARRIVEEELQRETLSIVGWRDVPTNEGVLGEI
ALSSLPHIEQIFVNAPAGWRPRDMERRLFIARRRIEKRLEADKDFYVCSLSNLVNIYKGLCMPADLPRFYLDLADLRLES
AICLFHQRFSTNTVPRWPLAQPFRYLAHNGEINTITGNRQWARARTYKFQTPLIPDLHDAAPFVNETGSDSSSMDNMLEL
LLAGGMDIIRAMRLLVPPAWQNNPDMDPELRAFFDFNSMHMEPWDGPAGIVMSDGRFAACNLDRNGLRPARYVITKDKLI
TCASEVGIWDYQPDEVVEKGRVGPGELMVIDTRSGRILHSAETDDDLKSRHPYKEWMEKNVRRLVPFEDLPDEEVGSREL
DDDTLASYQKQFNYSAEELDSVIRVLGENGQEAVGSMGDDTPFAVLSSQPRIIYDYFRQQFAQVTNPPIDPLREAHVMSL
ATSIGREMNVFCEAEGQAHRLSFKSPILLYSDFKQLTTMKEEHYRADTLDITFDVTKTTLEATVKELCDKAEKMVRSGTV
LLVLSDRNIAKDRLPVPAPMAVGAIQTRLVDQSLRCDANIIVETASARDPHHFAVLLGFGATAIYPYLAYETLGRLVDTH
AIAKDYRTVMLNYRNGINKGLYKIMSKMGISTIASYRCSKLFEAVGLHDDVVGLCFQGAVSRIGGASFEDFQQDLLNLSK
RAWLARKPISQGGLLKYVHGGEYHAYNPDVVRTLQQAVQSGEYSDYQEYAKLVNERPATTLRDLLAITPGENAVNIADVE
PASELFKRFDTAAMSIGALSPEAHEALAEAMNSIGGNSNSGEGGEDPARYGTNKVSRIKQVASGRFGVTPAYLVNADVIQ
IKVAQGAKPGEGGQLPGDKVTPYIAKLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQVNPKAMISVKLVSEPGVGTI
ATGVAKAYADLITIAGYDGGTGASPLSSVKYAGCPWELGLVETQQALVANGLRHKIRLQVDGGLKTGVDIIKAAILGAES
FGFGTGPMVALGCKYLRICHLNNCATGVATQDDKLRKNHYHGLPFKVTNYFEFIARETRELMAQLGVTRLVDLIGRTDLL
KELDGFTAKQQKLALSKLLETAEPHPGKALYCTENNPPFDNGLLNAQLLQQAKPFVDERQSKTFWFDIRNTDRSVGASLS
GYIAQTHGDQGLAADPIKAYFNGTAGQSFGVWNAGGVELYLTGDANDYVGKGMAGGLIAIRPPVGSAFRSHEASIIGNTC
LYGATGGRLYAAGRAGERFGVRNSGAITVVEGIGDNGCEYMTGGIVCILGKTGVNFGAGMTGGFAYVLDESGDFRKRVNP
ELVEVLSVDDLAIHEEHLRGLITEHVQHTGSQRGEEILANWSTFATKFALVKPKSSDVKALLGHRSRSAAELRVQAQ
>Mature_1516_residues
TRKPRRHALSVPVRSGSEVGFPQSLGEVHDMLYDKSLERDNCGFGLIAHIEGEPSHKVVRTAIHALARMQHRGAILADGK
TGDGCGLLLQKPDRFFRIVAQERGWRLAKNYAVGMLFLNKDPELAAAARRIVEEELQRETLSIVGWRDVPTNEGVLGEIA
LSSLPHIEQIFVNAPAGWRPRDMERRLFIARRRIEKRLEADKDFYVCSLSNLVNIYKGLCMPADLPRFYLDLADLRLESA
ICLFHQRFSTNTVPRWPLAQPFRYLAHNGEINTITGNRQWARARTYKFQTPLIPDLHDAAPFVNETGSDSSSMDNMLELL
LAGGMDIIRAMRLLVPPAWQNNPDMDPELRAFFDFNSMHMEPWDGPAGIVMSDGRFAACNLDRNGLRPARYVITKDKLIT
CASEVGIWDYQPDEVVEKGRVGPGELMVIDTRSGRILHSAETDDDLKSRHPYKEWMEKNVRRLVPFEDLPDEEVGSRELD
DDTLASYQKQFNYSAEELDSVIRVLGENGQEAVGSMGDDTPFAVLSSQPRIIYDYFRQQFAQVTNPPIDPLREAHVMSLA
TSIGREMNVFCEAEGQAHRLSFKSPILLYSDFKQLTTMKEEHYRADTLDITFDVTKTTLEATVKELCDKAEKMVRSGTVL
LVLSDRNIAKDRLPVPAPMAVGAIQTRLVDQSLRCDANIIVETASARDPHHFAVLLGFGATAIYPYLAYETLGRLVDTHA
IAKDYRTVMLNYRNGINKGLYKIMSKMGISTIASYRCSKLFEAVGLHDDVVGLCFQGAVSRIGGASFEDFQQDLLNLSKR
AWLARKPISQGGLLKYVHGGEYHAYNPDVVRTLQQAVQSGEYSDYQEYAKLVNERPATTLRDLLAITPGENAVNIADVEP
ASELFKRFDTAAMSIGALSPEAHEALAEAMNSIGGNSNSGEGGEDPARYGTNKVSRIKQVASGRFGVTPAYLVNADVIQI
KVAQGAKPGEGGQLPGDKVTPYIAKLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQVNPKAMISVKLVSEPGVGTIA
TGVAKAYADLITIAGYDGGTGASPLSSVKYAGCPWELGLVETQQALVANGLRHKIRLQVDGGLKTGVDIIKAAILGAESF
GFGTGPMVALGCKYLRICHLNNCATGVATQDDKLRKNHYHGLPFKVTNYFEFIARETRELMAQLGVTRLVDLIGRTDLLK
ELDGFTAKQQKLALSKLLETAEPHPGKALYCTENNPPFDNGLLNAQLLQQAKPFVDERQSKTFWFDIRNTDRSVGASLSG
YIAQTHGDQGLAADPIKAYFNGTAGQSFGVWNAGGVELYLTGDANDYVGKGMAGGLIAIRPPVGSAFRSHEASIIGNTCL
YGATGGRLYAAGRAGERFGVRNSGAITVVEGIGDNGCEYMTGGIVCILGKTGVNFGAGMTGGFAYVLDESGDFRKRVNPE
LVEVLSVDDLAIHEEHLRGLITEHVQHTGSQRGEEILANWSTFATKFALVKPKSSDVKALLGHRSRSAAELRVQAQ

Specific function: NITROGEN METABOLISM, GLUTAMATE BIOSYNTHESIS. THE CATALYZED REACTION BRINGS TOGETHER THE NITROGEN AND CARBON METABOLISM. [C]

COG id: COG0069

COG function: function code E; Glutamate synthase domain 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI308199519, Length=1486, Percent_Identity=99.7981157469717, Blast_Score=3070, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570289, Length=1533, Percent_Identity=41.9439008480104, Blast_Score=1086, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320030, Length=1528, Percent_Identity=41.9502617801047, Blast_Score=1140, Evalue=0.0,
Organism=Drosophila melanogaster, GI28574881, Length=1498, Percent_Identity=43.3911882510013, Blast_Score=1147, Evalue=0.0,
Organism=Drosophila melanogaster, GI24665539, Length=1498, Percent_Identity=43.3911882510013, Blast_Score=1147, Evalue=0.0,
Organism=Drosophila melanogaster, GI24665547, Length=369, Percent_Identity=44.7154471544715, Blast_Score=285, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24665543, Length=369, Percent_Identity=44.7154471544715, Blast_Score=285, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR002932
- InterPro:   IPR006982
- InterPro:   IPR002489 [H]

Pfam domain/function: PF00310 GATase_2; PF04898 Glu_syn_central; PF01645 Glu_synthase; PF01493 GXGXG [H]

EC number: =1.4.1.13 [H]

Molecular weight: Translated: 166707; Mature: 166576

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKPRRHALSVPVRSGSEVGFPQSLGEVHDMLYDKSLERDNCGFGLIAHIEGEPSHKVV
CCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHH
RTAIHALARMQHRGAILADGKTGDGCGLLLQKPDRFFRIVAQERGWRLAKNYAVGMLFLN
HHHHHHHHHHHHCCCEEECCCCCCCCEEEECCCCHHHHHHHHHCCCEEECCCEEEEEEEC
KDPELAAAARRIVEEELQRETLSIVGWRDVPTNEGVLGEIALSSLPHIEQIFVNAPAGWR
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHCCCCCHHHEEECCCCCC
PRDMERRLFIARRRIEKRLEADKDFYVCSLSNLVNIYKGLCMPADLPRFYLDLADLRLES
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AICLFHQRFSTNTVPRWPLAQPFRYLAHNGEINTITGNRQWARARTYKFQTPLIPDLHDA
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHCEEECCCCCCCCHHC
APFVNETGSDSSSMDNMLELLLAGGMDIIRAMRLLVPPAWQNNPDMDPELRAFFDFNSMH
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHEEEECCCCC
MEPWDGPAGIVMSDGRFAACNLDRNGLRPARYVITKDKLITCASEVGIWDYQPDEVVEKG
CCCCCCCCCEEEECCEEEEECCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCHHHHHHCC
RVGPGELMVIDTRSGRILHSAETDDDLKSRHPYKEWMEKNVRRLVPFEDLPDEEVGSREL
CCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCC
DDDTLASYQKQFNYSAEELDSVIRVLGENGQEAVGSMGDDTPFAVLSSQPRIIYDYFRQQ
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEECCCCCHHHHHHHHH
FAQVTNPPIDPLREAHVMSLATSIGREMNVFCEAEGQAHRLSFKSPILLYSDFKQLTTMK
HHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCEEEHHHHHHHHHHH
EEHYRADTLDITFDVTKTTLEATVKELCDKAEKMVRSGTVLLVLSDRNIAKDRLPVPAPM
HHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCH
AVGAIQTRLVDQSLRCDANIIVETASARDPHHFAVLLGFGATAIYPYLAYETLGRLVDTH
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
AIAKDYRTVMLNYRNGINKGLYKIMSKMGISTIASYRCSKLFEAVGLHDDVVGLCFQGAV
HHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SRIGGASFEDFQQDLLNLSKRAWLARKPISQGGLLKYVHGGEYHAYNPDVVRTLQQAVQS
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHC
GEYSDYQEYAKLVNERPATTLRDLLAITPGENAVNIADVEPASELFKRFDTAAMSIGALS
CCCCCHHHHHHHHCCCCHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
PEAHEALAEAMNSIGGNSNSGEGGEDPARYGTNKVSRIKQVASGRFGVTPAYLVNADVIQ
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCEEECCCEEE
IKVAQGAKPGEGGQLPGDKVTPYIAKLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQ
EEEECCCCCCCCCCCCCCCCCHHHHHHEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
VNPKAMISVKLVSEPGVGTIATGVAKAYADLITIAGYDGGTGASPLSSVKYAGCPWELGL
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCHHHCCCCCCCEECCH
VETQQALVANGLRHKIRLQVDGGLKTGVDIIKAAILGAESFGFGTGPMVALGCKYLRICH
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEEEE
LNNCATGVATQDDKLRKNHYHGLPFKVTNYFEFIARETRELMAQLGVTRLVDLIGRTDLL
CCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELDGFTAKQQKLALSKLLETAEPHPGKALYCTENNPPFDNGLLNAQLLQQAKPFVDERQ
HHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCHHHCC
SKTFWFDIRNTDRSVGASLSGYIAQTHGDQGLAADPIKAYFNGTAGQSFGVWNAGGVELY
CCEEEEEECCCCHHHCCCHHCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEE
LTGDANDYVGKGMAGGLIAIRPPVGSAFRSHEASIIGNTCLYGATGGRLYAAGRAGERFG
EECCCCCHHCCCCCCCEEEEECCCCHHHHCCCCCEECCEEEECCCCCEEEECCCCCCCCC
VRNSGAITVVEGIGDNGCEYMTGGIVCILGKTGVNFGAGMTGGFAYVLDESGDFRKRVNP
CCCCCCEEEEECCCCCCCCEECCCEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHCCCH
ELVEVLSVDDLAIHEEHLRGLITEHVQHTGSQRGEEILANWSTFATKFALVKPKSSDVKA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHH
LLGHRSRSAAELRVQAQ
HHCCCCCCCEEEEEECC
>Mature Secondary Structure 
TRKPRRHALSVPVRSGSEVGFPQSLGEVHDMLYDKSLERDNCGFGLIAHIEGEPSHKVV
CCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHH
RTAIHALARMQHRGAILADGKTGDGCGLLLQKPDRFFRIVAQERGWRLAKNYAVGMLFLN
HHHHHHHHHHHHCCCEEECCCCCCCCEEEECCCCHHHHHHHHHCCCEEECCCEEEEEEEC
KDPELAAAARRIVEEELQRETLSIVGWRDVPTNEGVLGEIALSSLPHIEQIFVNAPAGWR
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHCCCCCHHHEEECCCCCC
PRDMERRLFIARRRIEKRLEADKDFYVCSLSNLVNIYKGLCMPADLPRFYLDLADLRLES
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AICLFHQRFSTNTVPRWPLAQPFRYLAHNGEINTITGNRQWARARTYKFQTPLIPDLHDA
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHCEEECCCCCCCCHHC
APFVNETGSDSSSMDNMLELLLAGGMDIIRAMRLLVPPAWQNNPDMDPELRAFFDFNSMH
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHEEEECCCCC
MEPWDGPAGIVMSDGRFAACNLDRNGLRPARYVITKDKLITCASEVGIWDYQPDEVVEKG
CCCCCCCCCEEEECCEEEEECCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCHHHHHHCC
RVGPGELMVIDTRSGRILHSAETDDDLKSRHPYKEWMEKNVRRLVPFEDLPDEEVGSREL
CCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCC
DDDTLASYQKQFNYSAEELDSVIRVLGENGQEAVGSMGDDTPFAVLSSQPRIIYDYFRQQ
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEECCCCCHHHHHHHHH
FAQVTNPPIDPLREAHVMSLATSIGREMNVFCEAEGQAHRLSFKSPILLYSDFKQLTTMK
HHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCEEEHHHHHHHHHHH
EEHYRADTLDITFDVTKTTLEATVKELCDKAEKMVRSGTVLLVLSDRNIAKDRLPVPAPM
HHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCH
AVGAIQTRLVDQSLRCDANIIVETASARDPHHFAVLLGFGATAIYPYLAYETLGRLVDTH
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
AIAKDYRTVMLNYRNGINKGLYKIMSKMGISTIASYRCSKLFEAVGLHDDVVGLCFQGAV
HHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SRIGGASFEDFQQDLLNLSKRAWLARKPISQGGLLKYVHGGEYHAYNPDVVRTLQQAVQS
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHC
GEYSDYQEYAKLVNERPATTLRDLLAITPGENAVNIADVEPASELFKRFDTAAMSIGALS
CCCCCHHHHHHHHCCCCHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
PEAHEALAEAMNSIGGNSNSGEGGEDPARYGTNKVSRIKQVASGRFGVTPAYLVNADVIQ
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCEEECCCEEE
IKVAQGAKPGEGGQLPGDKVTPYIAKLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQ
EEEECCCCCCCCCCCCCCCCCHHHHHHEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
VNPKAMISVKLVSEPGVGTIATGVAKAYADLITIAGYDGGTGASPLSSVKYAGCPWELGL
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCHHHCCCCCCCEECCH
VETQQALVANGLRHKIRLQVDGGLKTGVDIIKAAILGAESFGFGTGPMVALGCKYLRICH
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEEEE
LNNCATGVATQDDKLRKNHYHGLPFKVTNYFEFIARETRELMAQLGVTRLVDLIGRTDLL
CCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELDGFTAKQQKLALSKLLETAEPHPGKALYCTENNPPFDNGLLNAQLLQQAKPFVDERQ
HHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCHHHCC
SKTFWFDIRNTDRSVGASLSGYIAQTHGDQGLAADPIKAYFNGTAGQSFGVWNAGGVELY
CCEEEEEECCCCHHHCCCHHCEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEE
LTGDANDYVGKGMAGGLIAIRPPVGSAFRSHEASIIGNTCLYGATGGRLYAAGRAGERFG
EECCCCCHHCCCCCCCEEEEECCCCHHHHCCCCCEECCEEEECCCCCEEEECCCCCCCCC
VRNSGAITVVEGIGDNGCEYMTGGIVCILGKTGVNFGAGMTGGFAYVLDESGDFRKRVNP
CCCCCCEEEEECCCCCCCCEECCCEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHCCCH
ELVEVLSVDDLAIHEEHLRGLITEHVQHTGSQRGEEILANWSTFATKFALVKPKSSDVKA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHH
LLGHRSRSAAELRVQAQ
HHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3326786; 9278503; 1673677; 2643092 [H]