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The map label for this gene is yfhH

Identifier: 218696188

GI number: 218696188

Start: 2921996

End: 2922844

Strand: Direct

Name: yfhH

Synonym: EC55989_2848

Alternate gene names: 218696188

Gene position: 2921996-2922844 (Clockwise)

Preceding gene: 218696185

Following gene: 218696189

Centisome position: 56.68

GC content: 51.94

Gene sequence:

>849_bases
ATGAACGGCTTACTTCGTATCCGTCAGCGTTACCAGGGGCTTGCCCAGAGTGATAAAAAACTGGCGGATTATCTGCTGCT
ACAACCTGATACGGCGCGCCATTTAAGCTCTCAGCAACTGGCCAACGAAGCCGGAGTCAGTCAGTCCAGCGTCGTGAAGT
TCGCGCAAAAACTCGGCTATAAAGGTTTTCCGGCGCTTAAGTTGGCGTTGAGTGAAGCGCTGGCAAGCCAGCCGGAATCG
CCCTCCGTGCCCATTCATAACCAAATCCGCGGTGATGATCCGTTACGGCTGGTCGGCGAAAAACTGATTAAAGAAAATAC
TGCCGCTATGTACGCAACGCTAAACGTTAATAGTGAAGAGAAACTGCATGAATGCGTAACAATGTTGCGCTCTGCGCGGC
GGATAATTCTGACCGGTATTGGCGCTTCGGGTCTGGTGGCGCAAAACTTTGCCTGGAAGCTGATGAAGATTGGCTTCAAT
GCTGCCGCAGTGCGCGATATGCATGCGCTACTCGCAACAGTACAGGCGTCGTCCCCTGACGATCTGTTATTAGCCATTTC
CTACACCGGTGTACGACGCGAGTTAAACCTGGCGGCAGATGAGATGCTGCGAGTGGGCGGAAAAGTGCTGGCGATTACCG
GCTTTACTCCGAATGCCCTGCAACAGCGTGCTTCTCATTGCCTGTATACCATTGCCGAAGAACAAGCGACAAACAGCGCT
TCAATCTCTGCTTGTCACGCTCAGGGAATGTTAACGGATTTGCTGTTCATTGCGCTGATTCAGCAGGATCTGGAACTGGC
ACCAGAACGTATTCGTCATAGTGAAGCGCTGGTGAAAAAACTGGTCTGA

Upstream 100 bases:

>100_bases
AATTTTTAATTCATGGCAATTAGCGGCAATGGAATATAAAATTCACTCGCGTGTCTCTCATATTGCCTGTTGTCGCCACT
ATTTCATCGCGAGGAAAGAT

Downstream 100 bases:

>100_bases
GTAAAGAATGCGCGTATAATGCCCGCCCGGTTTGTGTTGTTTTGAGAGTTTCCTTATGGCGTTGTTAATCACTAAAAAAT
GCATCAATTGTGATATGTGT

Product: putative DNA-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNGLLRIRQRYQGLAQSDKKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPES
PSVPIHNQIRGDDPLRLVGEKLIKENTAAMYATLNVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGFN
AAAVRDMHALLATVQASSPDDLLLAISYTGVRRELNLAADEMLRVGGKVLAITGFTPNALQQRASHCLYTIAEEQATNSA
SISACHAQGMLTDLLFIALIQQDLELAPERIRHSEALVKKLV

Sequences:

>Translated_282_residues
MNGLLRIRQRYQGLAQSDKKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPES
PSVPIHNQIRGDDPLRLVGEKLIKENTAAMYATLNVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGFN
AAAVRDMHALLATVQASSPDDLLLAISYTGVRRELNLAADEMLRVGGKVLAITGFTPNALQQRASHCLYTIAEEQATNSA
SISACHAQGMLTDLLFIALIQQDLELAPERIRHSEALVKKLV
>Mature_282_residues
MNGLLRIRQRYQGLAQSDKKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPES
PSVPIHNQIRGDDPLRLVGEKLIKENTAAMYATLNVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGFN
AAAVRDMHALLATVQASSPDDLLLAISYTGVRRELNLAADEMLRVGGKVLAITGFTPNALQQRASHCLYTIAEEQATNSA
SISACHAQGMLTDLLFIALIQQDLELAPERIRHSEALVKKLV

Specific function: Unknown

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI87082130, Length=282, Percent_Identity=100, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1788767, Length=272, Percent_Identity=35.6617647058824, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788159, Length=195, Percent_Identity=27.1794871794872, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082369, Length=274, Percent_Identity=21.5328467153285, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): YFHH_ECOLI (P37767)

Other databases:

- EMBL:   D64044
- EMBL:   U36841
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   X72336
- RefSeq:   AP_003147.1
- RefSeq:   NP_417056.2
- ProteinModelPortal:   P37767
- DIP:   DIP-12050N
- STRING:   P37767
- EnsemblBacteria:   EBESCT00000003476
- EnsemblBacteria:   EBESCT00000014810
- GeneID:   947030
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2545
- KEGG:   eco:b2561
- EchoBASE:   EB2214
- EcoGene:   EG12308
- eggNOG:   COG1737
- GeneTree:   EBGT00050000010596
- HOGENOM:   HBG725281
- OMA:   LHECVAM
- ProtClustDB:   PRK11557
- BioCyc:   EcoCyc:EG12308-MONOMER
- Genevestigator:   P37767
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF01418 HTH_6; PF01380 SIS

EC number: NA

Molecular weight: Translated: 30708; Mature: 30708

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS51071 HTH_RPIR; PS51464 SIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLLRIRQRYQGLAQSDKKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGY
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
KGFPALKLALSEALASQPESPSVPIHNQIRGDDPLRLVGEKLIKENTAAMYATLNVNSEE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHH
KLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGFNAAAVRDMHALLATVQASSPD
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
DLLLAISYTGVRRELNLAADEMLRVGGKVLAITGFTPNALQQRASHCLYTIAEEQATNSA
CEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
SISACHAQGMLTDLLFIALIQQDLELAPERIRHSEALVKKLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGLLRIRQRYQGLAQSDKKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGY
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
KGFPALKLALSEALASQPESPSVPIHNQIRGDDPLRLVGEKLIKENTAAMYATLNVNSEE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHH
KLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGFNAAAVRDMHALLATVQASSPD
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
DLLLAISYTGVRRELNLAADEMLRVGGKVLAITGFTPNALQQRASHCLYTIAEEQATNSA
CEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
SISACHAQGMLTDLLFIALIQQDLELAPERIRHSEALVKKLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 1602968; 7984428