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The map label for this gene is yphC

Identifier: 218696172

GI number: 218696172

Start: 2898053

End: 2899114

Strand: Reverse

Name: yphC

Synonym: EC55989_2831

Alternate gene names: 218696172

Gene position: 2899114-2898053 (Counterclockwise)

Preceding gene: 218696173

Following gene: 218696171

Centisome position: 56.24

GC content: 55.46

Gene sequence:

>1062_bases
ATGAAAACGATGCTGGCAGCTTATTTACCAGGAAATTCAACCGTCGATCTGCGGGAAGTTGCGGTGCCGACGCCGGGGAT
TAACCAGGTACTGATCAAAATGAAATCCTCCGGGATTTGCGGAAGCGATGTCCACTATATCTATCATCAACACCGTGCCA
CGGCGGCGGCACCCGATAAACCGTTATACCAGGGATTTATCAACGGTCATGAACCGTGCGGGCAGATTGTGGCGATGGGG
CAAGGCTGTCGCCATTTTAAAGAGGGTGATCGCGTGCTGGTGTATCACATTTCTGGCTGTGGTTTTTGCCCGAACTGCCG
CCGCGGCTTTCCTATCTCTTGTACTGGCAAAGGAAAAGCGGCTTACGGCTGGCAGCGTGACGGCGGTCATGCCGAATATC
TGCTGGCGGAAGAAAAAGATCTGATCCTCCTGCCGGATGCGCTGAGCTACGAAGATGGTGCGTTTATCAGTTGCGGCGTT
GGCACGGCCTATGAAGGGATTTTGCGCGGCGAAGTTTCCGGCAGTGATAACGTGCTGGTGGTCGGTCTGGGGCCAGTCGG
CATGATGGCGATGATGCTGGCGAAAGGTCGCGGTGCAAAACGGATCATCGGCGTTGATATGCTGCCGGAACGTCTGGCGA
TGGCAAAACAGTTAGGGGTGATGGAGCACGGCTATTTAGCAACCACCGAAGGTCTGCCGCAGATTATCGCCGAACTCACC
CACGGTGGCGCGGATGTTGCGCTCGATTGTTCTGGTAATGCCGCAGGTCGCTTGCTGGCACTGCGATCCACCGCTGACTG
GGGACGGGTGGTTTACATCGGAGAAACCGGAAAAGTGGAGTTCGAGGTCAGCGCCGATCTGATGCACCATCAACGGCGGA
TTATCGGCTCCTGGGTGACCAGTCTGTTCCATATGGAAAAATGCGCCCATGATCTGACGGACTGGAAACTGTGGCCGCGT
AACGCCATTACCCATCGCTTCTCGCTGGAACAGGCAGGTGATGCCTATGCGCTGATGGCGAGCGGCAAATGCGGGAAAGT
TGTGATTAACTTCCCGGATTAA

Upstream 100 bases:

>100_bases
TGCTGACCCAGCGAAGCAGTAAAGCGAAACGCTAAACCTTAACGCCCCTGGCGCGGGTGCGGCAGGGATGAAAATTAATC
GTATTGTTAATGAGGGATTT

Downstream 100 bases:

>100_bases
GGAGTTAGCGGATGACCATCTATACCTTATCCCACGGGTCGCTAAAGCTGGACGTTTCTGACCAGGGCGGCGTAATCGAA
GGCTTCTGGCGCGATACGAC

Product: putative oxidoreductase, Zn-dependent and NAD(P)-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMG
QGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGV
GTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMEHGYLATTEGLPQIIAELT
HGGADVALDCSGNAAGRLLALRSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPR
NAITHRFSLEQAGDAYALMASGKCGKVVINFPD

Sequences:

>Translated_353_residues
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMG
QGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGV
GTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMEHGYLATTEGLPQIIAELT
HGGADVALDCSGNAAGRLLALRSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPR
NAITHRFSLEQAGDAYALMASGKCGKVVINFPD
>Mature_353_residues
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMG
QGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGV
GTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMEHGYLATTEGLPQIIAELT
HGGADVALDCSGNAAGRLLALRSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPR
NAITHRFSLEQAGDAYALMASGKCGKVVINFPD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=27.5, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=26.5753424657534, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4501939, Length=354, Percent_Identity=27.683615819209, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI156627571, Length=371, Percent_Identity=27.2237196765499, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=25.5494505494505, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI71743840, Length=363, Percent_Identity=24.2424242424242, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI262073058, Length=363, Percent_Identity=24.2424242424242, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=25.2032520325203, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI34577061, Length=364, Percent_Identity=25.5494505494505, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI71565154, Length=364, Percent_Identity=24.4505494505494, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI194239674, Length=365, Percent_Identity=26.5753424657534, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI13236495, Length=365, Percent_Identity=26.5753424657534, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=99.1501416430595, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=31.6860465116279, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787863, Length=366, Percent_Identity=28.9617486338798, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788073, Length=268, Percent_Identity=31.3432835820896, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=25.3086419753086, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=27.4725274725275, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786825, Length=261, Percent_Identity=27.9693486590038, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=386, Percent_Identity=25.6476683937824, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081918, Length=350, Percent_Identity=26.2857142857143, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790718, Length=256, Percent_Identity=26.171875, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=275, Percent_Identity=32, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=215, Percent_Identity=32.093023255814, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=23.8482384823848, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=23.7196765498652, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=24.633431085044, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=307, Percent_Identity=25.0814332247557, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=26.647564469914, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=24.9275362318841, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=348, Percent_Identity=26.4367816091954, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=383, Percent_Identity=22.976501305483, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=367, Percent_Identity=25.6130790190736, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=29.4339622641509, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=297, Percent_Identity=24.5791245791246, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=259, Percent_Identity=25.0965250965251, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=26.3537906137184, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=269, Percent_Identity=23.4200743494424, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=266, Percent_Identity=30.8270676691729, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=25.2054794520548, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17737897, Length=263, Percent_Identity=29.277566539924, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI221457811, Length=336, Percent_Identity=23.2142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=336, Percent_Identity=23.2142857142857, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551930, Length=336, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 38092; Mature: 38092

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDK
CCCEEEEECCCCCCEEHHEEECCCCCCCCEEEEEECCCCCCCCHHHEEEHHCCCCCCCCC
PLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKA
HHHHHHCCCCCCHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCC
AYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLV
CCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHEEEEECCCCCCEEE
VGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMEHGYLATTEGLPQIIAELT
EEECHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
HGGADVALDCSGNAAGRLLALRSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVT
CCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHH
SLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD
HHHHHHHHHHHHHCCEECCCCHHEEEEEHHHCCCEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDK
CCCEEEEECCCCCCEEHHEEECCCCCCCCEEEEEECCCCCCCCHHHEEEHHCCCCCCCCC
PLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKA
HHHHHHCCCCCCHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCC
AYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLV
CCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHEEEEECCCCCCEEE
VGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMEHGYLATTEGLPQIIAELT
EEECHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
HGGADVALDCSGNAAGRLLALRSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVT
CCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHH
SLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD
HHHHHHHHHHHHHCCEECCCCHHEEEEEHHHCCCEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]