Click here to switch to the map view.

The map label for this gene is cscK

Identifier: 218696005

GI number: 218696005

Start: 2707550

End: 2708464

Strand: Reverse

Name: cscK

Synonym: EC55989_2655

Alternate gene names: 218696005

Gene position: 2708464-2707550 (Counterclockwise)

Preceding gene: 218696007

Following gene: 218696004

Centisome position: 52.54

GC content: 52.13

Gene sequence:

>915_bases
ATGTCAGCCAAAGTATGGGTTTTAGGGGATGCGGTCGTAGATCTCTTGCCAGAATCAGACGGGCGCCTACTGCCTTGTCC
TGGCGGCGCGCCAGCTAACGTTGCGGTGGGAATCGCCAGATTAGGCGGAACAAGTGGGTTTATAGGTCGGGTGGGGGATG
ATCCTTTTGGTGCGTTAATGCAAAGAACGCTGCTAACTGAGGGAGTCGATATCACGTATCTGAAGCAAGATGAATGGCAC
CGGACATCCACGGTGCTTGTCGATCTGAACGATCAAGGGGAACGTTCATTTACGTTTATGGTCCGCCCCAGTGCCGATCT
TTTTTTAGAGACGACAGACTTGCCCTGCTGGCGACATGGCGAATGGTTACATCTCTGTTCAATTGCGTTGTCTGCCGAGC
CTTCGCGTACCAGCGCATTTACTGCGATGACGGCGATCCGGCATGCCGGAGGTTTTGTCAGCTTCGATCCTAATATTCGT
GAAGATCTATGGCAAGACGAGCATTTGCTCCGCTTGTGTTTGCGGCAGGCGCTACAACTGGCGGATGTCGTCAAGCTCTC
GGAAGAAGAATGGCGACTTATCAGTGGAAAAACACAGAACGATCGGGATATATGCGCCCTGGCAAAAGAGTATGAGATCG
CCATGCTGTTGGTGACTAAAGGTGCAGAAGGTGTGGTGGTCTGTTATCGAGGACAAGTTCACCATTTTGCTGGAATGTCT
GTGAATTGTGTCGATAGCACGGGGGCGGGAGATGCGTTCGTTGCCGGGTTACTCACAGGTCTGTCCTCTACGGGATTATC
TACAGATGAGAGAGAAATGCGACGAATTATCGATCTCGCTCAACGTTGCGGAGCGCTTGCAGTAACGGCGAAAGGGGCAA
TGACAGCGCTGCCATGTCGACAAGAACTGGAATAG

Upstream 100 bases:

>100_bases
CGTTTTGTGATCGAATATGCATGTTTTAGTAAATCCATGACGATTTTGCGAAAAAGAGGTTTATCACTATGCGTAACTCA
GATGAATTTAAGGGAAAAAA

Downstream 100 bases:

>100_bases
TGAGAAGTAAACGGCGAAGTCGCTCTTATCTCTAAATAGGACGTGAATTTTTTAACGACAGGCAGGTAATTATGGCACTG
AATATTCCATTCAGAAATGC

Product: aminoimidazole riboside kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSAKVWVLGDAVVDLLPESDGRLLPCPGGAPANVAVGIARLGGTSGFIGRVGDDPFGALMQRTLLTEGVDITYLKQDEWH
RTSTVLVDLNDQGERSFTFMVRPSADLFLETTDLPCWRHGEWLHLCSIALSAEPSRTSAFTAMTAIRHAGGFVSFDPNIR
EDLWQDEHLLRLCLRQALQLADVVKLSEEEWRLISGKTQNDRDICALAKEYEIAMLLVTKGAEGVVVCYRGQVHHFAGMS
VNCVDSTGAGDAFVAGLLTGLSSTGLSTDEREMRRIIDLAQRCGALAVTAKGAMTALPCRQELE

Sequences:

>Translated_304_residues
MSAKVWVLGDAVVDLLPESDGRLLPCPGGAPANVAVGIARLGGTSGFIGRVGDDPFGALMQRTLLTEGVDITYLKQDEWH
RTSTVLVDLNDQGERSFTFMVRPSADLFLETTDLPCWRHGEWLHLCSIALSAEPSRTSAFTAMTAIRHAGGFVSFDPNIR
EDLWQDEHLLRLCLRQALQLADVVKLSEEEWRLISGKTQNDRDICALAKEYEIAMLLVTKGAEGVVVCYRGQVHHFAGMS
VNCVDSTGAGDAFVAGLLTGLSSTGLSTDEREMRRIIDLAQRCGALAVTAKGAMTALPCRQELE
>Mature_303_residues
SAKVWVLGDAVVDLLPESDGRLLPCPGGAPANVAVGIARLGGTSGFIGRVGDDPFGALMQRTLLTEGVDITYLKQDEWHR
TSTVLVDLNDQGERSFTFMVRPSADLFLETTDLPCWRHGEWLHLCSIALSAEPSRTSAFTAMTAIRHAGGFVSFDPNIRE
DLWQDEHLLRLCLRQALQLADVVKLSEEEWRLISGKTQNDRDICALAKEYEIAMLLVTKGAEGVVVCYRGQVHHFAGMSV
NCVDSTGAGDAFVAGLLTGLSSTGLSTDEREMRRIIDLAQRCGALAVTAKGAMTALPCRQELE

Specific function: Ribose metabolism; first step. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family

Homologues:

Organism=Homo sapiens, GI11545855, Length=294, Percent_Identity=26.8707482993197, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790193, Length=281, Percent_Identity=26.6903914590747, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082281, Length=273, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082343, Length=303, Percent_Identity=27.0627062706271, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532905, Length=284, Percent_Identity=27.4647887323944, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SCRK_ECOLX (P40713)

Other databases:

- EMBL:   X81461
- PIR:   S52161
- ProteinModelPortal:   P40713
- SMR:   P40713
- BRENDA:   2.7.1.4
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR002139
- PRINTS:   PR00990

Pfam domain/function: PF00294 PfkB

EC number: =2.7.1.4

Molecular weight: Translated: 33049; Mature: 32918

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKVWVLGDAVVDLLPESDGRLLPCPGGAPANVAVGIARLGGTSGFIGRVGDDPFGALM
CCCEEEEECHHHHHHCCCCCCCEEECCCCCCCHHEEEEEHHCCCCCCCCCCCCCHHHHHH
QRTLLTEGVDITYLKQDEWHRTSTVLVDLNDQGERSFTFMVRPSADLFLETTDLPCWRHG
HHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCC
EWLHLCSIALSAEPSRTSAFTAMTAIRHAGGFVSFDPNIREDLWQDEHLLRLCLRQALQL
CEEEEEEEHCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCHHHHHHHHHHHHHH
ADVVKLSEEEWRLISGKTQNDRDICALAKEYEIAMLLVTKGAEGVVVCYRGQVHHFAGMS
HHHHHCCCCCEEEECCCCCCCCHHHHHHHCCEEEEEEEECCCCEEEEEEECCEEEECCCE
VNCVDSTGAGDAFVAGLLTGLSSTGLSTDEREMRRIIDLAQRCGALAVTAKGAMTALPCR
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEECCCH
QELE
HHCC
>Mature Secondary Structure 
SAKVWVLGDAVVDLLPESDGRLLPCPGGAPANVAVGIARLGGTSGFIGRVGDDPFGALM
CCEEEEECHHHHHHCCCCCCCEEECCCCCCCHHEEEEEHHCCCCCCCCCCCCCHHHHHH
QRTLLTEGVDITYLKQDEWHRTSTVLVDLNDQGERSFTFMVRPSADLFLETTDLPCWRHG
HHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCC
EWLHLCSIALSAEPSRTSAFTAMTAIRHAGGFVSFDPNIREDLWQDEHLLRLCLRQALQL
CEEEEEEEHCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCHHHHHHHHHHHHHH
ADVVKLSEEEWRLISGKTQNDRDICALAKEYEIAMLLVTKGAEGVVVCYRGQVHHFAGMS
HHHHHCCCCCEEEECCCCCCCCHHHHHHHCCEEEEEEEECCCCEEEEEEECCEEEECCCE
VNCVDSTGAGDAFVAGLLTGLSSTGLSTDEREMRRIIDLAQRCGALAVTAKGAMTALPCR
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEECCCH
QELE
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA