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The map label for this gene is tehB

Identifier: 218694970

GI number: 218694970

Start: 1610096

End: 1610689

Strand: Direct

Name: tehB

Synonym: EC55989_1561

Alternate gene names: 218694970

Gene position: 1610096-1610689 (Clockwise)

Preceding gene: 218694969

Following gene: 218694971

Centisome position: 31.23

GC content: 45.45

Gene sequence:

>594_bases
ATGATCATTCGTGACGAAAACTATTTTACTGATAAATATGAATTAACCCGCACACACTCTGAAGTACTGGAAGCGGTGAA
AGTGGTTAAACCGGGTAAAACGCTGGATCTGGGCTGTGGCAATGGTCGTAACAGTCTTTACCTGGCAGCCAATGGTTATG
ATGTTGACGCATGGGATAAAAATGCCATGAGTATCGCCAATGTAGAGCGCATTAAATCCATTGAAAATCTGGATAATTTA
CACACCCGAGTCGTTGATCTGAATAACCTCACATTTGATAGACAGTACGATTTTATTCTTTCGACTGTGGTACTGATGTT
CCTTGAGGCTAAAACCATCCCCGGGTTGATTGCCAATATGCAACGTTGCACTAAACCTGGTGGTTACAACCTGATTGTGG
CGGCGATGGATACCGCTGATTATCCATGTACCGTCGGCTTCCCGTTTGCCTTCAAAGAGGGAGAATTACGTCGATATTAC
GAAGGCTGGGAGAGGGTGAAATACAATGAAGACGTCGGCGAGCTGCACCGCACCGACGCCAACGGTAATCGTATTAAACT
GCGTTTCGCCACGATGCTGGCACGTAAAAAATGA

Upstream 100 bases:

>100_bases
TTATTGCAATACTGCTCATCCGTACTTTTGCGCTTCTGATGCAGGGAAAATTGTTAGTCAGAACCGAGCGCGCCGTTTTA
ATGAAAGCAGAGGACAAAGA

Downstream 100 bases:

>100_bases
CCCGCTAAGAATAAGGCGCGTGAAAATTCCCCACGCTGAGATGATTTACTGTTCTTCTTTTCGGTAAGCATATTTTTTAT
CGAAGGGATGTGAAATTAAT

Product: tellurite resistance protein TehB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNL
HTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYY
EGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK

Sequences:

>Translated_197_residues
MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNL
HTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYY
EGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK
>Mature_197_residues
MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNL
HTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYY
EGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK

Specific function: Probable S-adenosyl-L-methionine dependent methyltransferase that is responsible for tellurite resistance when present in high copy number. Binds tellurite and S-adenosyl- L-methionine

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm (Probable). Note=Probably a peripheral membrane protein that interacts with TehA

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TehB family

Homologues:

Organism=Escherichia coli, GI1787700, Length=197, Percent_Identity=100, Blast_Score=409, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TEHB_ECOLI (P25397)

Other databases:

- EMBL:   M74072
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   A64895
- RefSeq:   AP_002053.1
- RefSeq:   NP_415947.1
- ProteinModelPortal:   P25397
- SMR:   P25397
- DIP:   DIP-10978N
- MINT:   MINT-1274665
- STRING:   P25397
- EnsemblBacteria:   EBESCT00000003908
- EnsemblBacteria:   EBESCT00000014576
- GeneID:   945979
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1426
- KEGG:   eco:b1430
- EchoBASE:   EB1830
- EcoGene:   EG11884
- eggNOG:   COG0500
- GeneTree:   EBGT00050000010799
- HOGENOM:   HBG296629
- OMA:   WDKNPMS
- ProtClustDB:   PRK11207
- BioCyc:   EcoCyc:EG11884-MONOMER
- Genevestigator:   P25397
- GO:   GO:0005737
- InterPro:   IPR004537
- InterPro:   IPR015985
- TIGRFAMs:   TIGR00477

Pfam domain/function: PF03848 TehB

EC number: NA

Molecular weight: Translated: 22531; Mature: 22531

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDK
CEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCC
NAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANM
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHH
QRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDA
HHHCCCCCCEEEEEEECCCCCCEEECCCEEECCCHHHHHHHHHHHCCCCCCHHHHHCCCC
NGNRIKLRFATMLARKK
CCCEEEEEEEHHHHCCC
>Mature Secondary Structure
MIIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDK
CEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCC
NAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANM
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHH
QRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDA
HHHCCCCCCEEEEEEECCCCCCEEECCCEEECCCHHHHHHHHHHHCCCCCCHHHHHCCCC
NGNRIKLRFATMLARKK
CCCEEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2060788; 9097039; 9278503; 8169225