Click here to switch to the map view.

The map label for this gene is paaH

Identifier: 218694941

GI number: 218694941

Start: 1576519

End: 1577946

Strand: Direct

Name: paaH

Synonym: EC55989_1531

Alternate gene names: 218694941

Gene position: 1576519-1577946 (Clockwise)

Preceding gene: 218694940

Following gene: 218694942

Centisome position: 30.58

GC content: 53.15

Gene sequence:

>1428_bases
ATGATGATAAATGTGCAAACTGTGGCAGTGATTGGGAGCGGCACCATGGGGGCTGGCATTGCTGAAGTTGCCGCCAGTCA
TGGACATCAGGTTTTACTGTATGACATTTCTGCTGAAGCGCTGACCCGCGCAATCGACGGGATACACGCGCGGCTAAATT
CACGCGTGACGCGGGGAAAACTGACCGCTGAAACCTGTGAACGCACATTGAAACGCCTTATCCCGGTGACCGATATTCAC
GCGCTGGCAGCAGCGAATCTGGTTATTGAAGCGGCGTCTGAGCGTCTGGAAGTCAAAAAAGCGCTCTTTGCACAGCTGGC
GGAAGTTTGCCCGCCACAAACGCTATTGACCACTAACACTTCGTCAATCTCTATAACCGCAATTGCTGCGGAGGTAAAAA
ATCCTGAACGTGTTGCGGGGCTGCATTTTTTTAACCCGGCACCGGTAATGAAGTTGGTGGAGGTGGTCAGTGGGCTGGCA
ACGGCGGCGGAAGTTGTTGAGCAGTTGTGTGAACTAACGTTGAGTTGGGGTAAGCAGCCTGTGCGCTGTCATTCGACTCC
TGGATTTATCGTTAACCGTGTTGCGCGTCCTTATTATTCCGAGGCCTGGCGGGCACTGGAAGAGCAGGTTGCTGTACCAG
AAGTGATTGACGCTGCACTTCGCGATGGCGCTGGTTTCCCGATGGGGCCGCTGGAATTAACCGATCTGATTGGTCAGGAC
GTCAATTTTGCTGTCACCTGTTCGGTGTTTAACGCTTTCTGGCAGGAGCGTCGTTTTTTACCTTCGCTGGTGCAACAGGA
ACTGGTGATTGGTGGACGGTTGGGCAAGAAAAGTGGGCTGGGCGTGTACGACTGGCGCGCGGAACGTGAGGCAGTTGTTG
GCCTGGAAGCGGTAAGCGACAGTTTTAGCCCAATGAAAGTAGAAAAGAAAAGTGACGGTGTCACGGAAATTGACGATGTT
TTATTGATTGAGACACAAGGCGAGACGGCACAGGCGCTGGCAATACGACTGGCACGCCCGGTGGTAGTGGTCGACAAAAT
GGCGGGCAAGGTGGTGACCATTGCTGCGGCAGCGGTGAACCCGGACTCAGCGACCCGCAAGGCCATTTATTACCTGCAAC
AGCAGGGCAAAACAGTGCTGCAAATTGCAGATTACCCAGGAATGCTGATTTGGCGAACGGTAGCAATGATCATCAATGAA
GCCCTTGATGCGCTGCAAAAAGGCGTGGCCTCTGAACAGGATATCGATACCGCCATGCGTCTTGGGGTGAATTATCCATA
TGGCCCGCTTGCCTGGGGAGCGCAACTTGGCTGGCAGCGAATATTAAGGCTCCTTGAAAATCTACAACATCACTATGGCG
AAGAACGCTATCGCCCATGTTCATTGCTGCGCCAACGAGCGCTTCTGGAGAGCGGTTATGAGTCATAA

Upstream 100 bases:

>100_bases
GAACGCGACTATCAGCGACTTGCCGGACGGAGCGCAGATTATCGTGAAGGTGTCAGTGCGTTCCTGGCCAAACGCTCACC
GCAGTTCACGGGGAAATAGC

Downstream 100 bases:

>100_bases
GGCCTGGCAAAATGCCCATGCAATGTATGAGAACGATGCCTGCGCTAAAGCGCTTGGCATCGACATTATCTCAATGGATG
AAGGCTTTGCTGTAGTGACC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRGKLTAETCERTLKRLIPVTDIH
ALAAANLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAVPEVIDAALRDGAGFPMGPLELTDLIGQD
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREAVVGLEAVSDSFSPMKVEKKSDGVTEIDDV
LLIETQGETAQALAIRLARPVVVVDKMAGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINE
ALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRLLENLQHHYGEERYRPCSLLRQRALLESGYES

Sequences:

>Translated_475_residues
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRGKLTAETCERTLKRLIPVTDIH
ALAAANLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAVPEVIDAALRDGAGFPMGPLELTDLIGQD
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREAVVGLEAVSDSFSPMKVEKKSDGVTEIDDV
LLIETQGETAQALAIRLARPVVVVDKMAGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINE
ALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRLLENLQHHYGEERYRPCSLLRQRALLESGYES
>Mature_475_residues
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRGKLTAETCERTLKRLIPVTDIH
ALAAANLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAVPEVIDAALRDGAGFPMGPLELTDLIGQD
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREAVVGLEAVSDSFSPMKVEKKSDGVTEIDDV
LLIETQGETAQALAIRLARPVVVVDKMAGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINE
ALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRLLENLQHHYGEERYRPCSLLRQRALLESGYES

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=296, Percent_Identity=41.2162162162162, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI296179427, Length=313, Percent_Identity=38.9776357827476, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=33.2167832167832, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=32.1917808219178, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=32.1917808219178, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=30.5084745762712, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1787661, Length=475, Percent_Identity=99.1578947368421, Blast_Score=965, Evalue=0.0,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=35.1145038167939, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1790281, Length=313, Percent_Identity=28.4345047923323, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=39.6551724137931, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=39.7959183673469, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=39.7923875432526, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=34.1637010676157, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=34.1637010676157, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=34.1637010676157, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=304, Percent_Identity=29.6052631578947, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=32.7402135231317, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=28.3687943262411, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=199, Percent_Identity=27.1356783919598, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203623, Length=199, Percent_Identity=27.1356783919598, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=34.0350877192982, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=34.0350877192982, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=34.0350877192982, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=32.7800829875519, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=27.9166666666667, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 51732; Mature: 51732

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRGK
CEEEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHCCC
LTAETCERTLKRLIPVTDIHALAAANLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLATAAEVVEQLCELTLSWGKQP
CCEEEEEEEECCCCCHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VRCHSTPGFIVNRVARPYYSEAWRALEEQVAVPEVIDAALRDGAGFPMGPLELTDLIGQD
EEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCC
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREAVVGLEAVSD
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHCC
SFSPMKVEKKSDGVTEIDDVLLIETQGETAQALAIRLARPVVVVDKMAGKVVTIAAAAVN
CCCCCEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHEEHHHCCCEEEEEEEECC
PDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINEALDALQKGVASEQDIDTAMR
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGVNYPYGPLAWGAQLGWQRILRLLENLQHHYGEERYRPCSLLRQRALLESGYES
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRGK
CEEEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHCCC
LTAETCERTLKRLIPVTDIHALAAANLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLATAAEVVEQLCELTLSWGKQP
CCEEEEEEEECCCCCHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VRCHSTPGFIVNRVARPYYSEAWRALEEQVAVPEVIDAALRDGAGFPMGPLELTDLIGQD
EEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCC
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREAVVGLEAVSD
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHCC
SFSPMKVEKKSDGVTEIDDVLLIETQGETAQALAIRLARPVVVVDKMAGKVVTIAAAAVN
CCCCCEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHEEHHHCCCEEEEEEEECC
PDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINEALDALQKGVASEQDIDTAMR
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGVNYPYGPLAWGAQLGWQRILRLLENLQHHYGEERYRPCSLLRQRALLESGYES
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]