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The map label for this gene is mukE

Identifier: 218694397

GI number: 218694397

Start: 1037073

End: 1037750

Strand: Direct

Name: mukE

Synonym: EC55989_0969

Alternate gene names: 218694397

Gene position: 1037073-1037750 (Clockwise)

Preceding gene: 218694396

Following gene: 218694398

Centisome position: 20.12

GC content: 52.51

Gene sequence:

>678_bases
ATGCCGGTTAAGCTGGCGCAGGCGCTGGCGAATCCGTTATTTCCGGCGCTGGACAGCGCCTTACGTTCAGGCCGCCATAT
TGGCCTCGACGAACTGGATAATCATGCATTCCTGATGGATTTTCAGGAATATCTGGAAGAGTTTTACGCGCGTTATAACG
TTGAGCTTATTCGCGCACCGGAAGGGTTCTTCTATTTACGCCCACGTTCCACCACTCTTATCCCGCGTTCCGTCTTGTCG
GAACTGGATATGATGGTCGGGAAAATCCTCTGTTATCTCTATCTCAGCCCGGAACGGCTGGCGAATGAGGGGATTTTCAC
CCAGCAGGAACTGTACGACGAACTGCTCACCCTGGCCGATGAAGCAAAACTGCTGAAACTGGTGAACAACCGTTCAACCG
GTTCAGACGTTGACCGTCAGAAGTTGCAGGAGAAAGTACGTTCTTCGCTCAACCGTCTGCGTCGTTTAGGCATGGTGTGG
TTTATGGGCCACGACAGCAGCAAGTTTCGCATTACCGAATCGGTGTTCCGCTTCGGAGCCGATGTGCGTGCTGGCGACGA
TCCCCGTGAAGCACAGCGTCGCCTGATTCGTGATGGCGAAGCAATGCCGATTGAAAATCATCTGCAACTCAACGATGAAA
CCGAAGAGAATCAGCCAGATAGCGGAGAGGAAGAATAA

Upstream 100 bases:

>100_bases
GCGCAAGCAGATTTCACCGGACTGCCAGCGAAATGGCAGCCGATTAATGATTACGGAGCCAAGGTACAGGCGCATGTCAT
CGACAAATATTGAACAAGTG

Downstream 100 bases:

>100_bases
TGATTGAACGCGGTAAATTTCGCTCACTGACGCTGATTAACTGGAACGGCTTTTTTGCCCGAACTTTTGACCTTGACGAG
CTGGTCACGACGCTTTCTGG

Product: condesin subunit E

Products: NA

Alternate protein names: Protein kicA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLS
ELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVW
FMGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE

Sequences:

>Translated_225_residues
MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLS
ELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVW
FMGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE
>Mature_224_residues
PVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSE
LDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWF
MGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE

Specific function: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interactio

COG id: COG3095

COG function: function code D; Uncharacterized protein involved in chromosome partitioning

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Restricted to the nucleoid region

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mukE family

Homologues:

Organism=Escherichia coli, GI226510932, Length=225, Percent_Identity=100, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUKE_ECOLI (P22524)

Other databases:

- EMBL:   D26440
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   X57550
- PIR:   B64832
- RefSeq:   AP_001553.1
- RefSeq:   NP_415443.2
- PDB:   3EUH
- PDBsum:   3EUH
- ProteinModelPortal:   P22524
- SMR:   P22524
- DIP:   DIP-10274N
- IntAct:   P22524
- MINT:   MINT-1227862
- STRING:   P22524
- EnsemblBacteria:   EBESCT00000003879
- EnsemblBacteria:   EBESCT00000016023
- GeneID:   945550
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0906
- KEGG:   eco:b0923
- EchoBASE:   EB1232
- EcoGene:   EG11252
- eggNOG:   COG3095
- GeneTree:   EBGT00050000011637
- HOGENOM:   HBG296837
- ProtClustDB:   PRK05256
- BioCyc:   EcoCyc:EG11252-MONOMER
- Genevestigator:   P22524
- GO:   GO:0005737
- GO:   GO:0009295
- HAMAP:   MF_01802
- InterPro:   IPR007385

Pfam domain/function: PF04288 MukE

EC number: NA

Molecular weight: Translated: 25985; Mature: 25854

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAP
CCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCEEEECC
EGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLAD
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHH
EAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWFMGHDSSKFRITESVFRFGA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCC
DVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAP
CHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCEEEECC
EGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLAD
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHH
EAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWFMGHDSSKFRITESVFRFGA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCC
DVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7513784; 8905232; 9278503; 1989883; 8602138